Protease-activated receptor 1 (PAR1) coupling to Gq/11 but not to Gi/o or G12/13 is mediated by discrete amino acids within the receptor second intracellular loop
Keywords: BBB; blood-brain barrier; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's medium; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptor; GRK2; G protein-coupled receptor kinase-2; InsP