PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte

► PLCε is required for TNFα-induced CCL2 expression in human keratinocytes. ► NF-κB pathway is essential for TNFα-induced CCL2 expression in human keratinocytes. ► PLCε constitutes a signaling pathway distinct from the NF-κB pathway. ► PLCε pathway cooperates with the NF-κB pathway to induce CCL2 expression.