Keywords: Dual-targeting; Multi-targeting; Proteomics; Bioinformatics; Polypharmacology;
مقالات ISI (ترجمه نشده)
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Keywords: Endocannabinoid system; Cannabinoid receptors; Polypharmacology; Molecular docking; U251MG glioblastoma cell line; U937 lymphoblastoid cells;
Keywords: Ebola treatment; Ebola prevention; Drug combination; Drug repurposing; Polypharmacology; EBOV; Ebola virus; NPC1; Niemann Pick C1 protein; IC50; half-maximum inhibitory concentrations;
Keywords: Computational target fishing; Reverse screening; Drug repositioning; Polypharmacology; Drug research; Functional foods
Keywords: Chemogenomics; Proteomics; Cheminformatics; Polypharmacology;
Keywords: Herbal medicinal products; Network pharmacology; Omic tools; Polypharmacology; Traditional chinese herbal medicines
Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds
Keywords: Diabetes; PTP-1B; PPAR; GLUT-4; Polypharmacology; Drug design;
Systems-level mechanisms of action of Panax ginseng: a network pharmacological approach
Keywords: network pharmacology; Panax ginseng; polypharmacology; traditional Asian medicine;
Gut hormone polyagonists for the treatment of type 2 diabetes
Keywords: GLP-1/Glucagon Co-agonism; Polypharmacology; Type 2 diabetes; Gip;
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Exploiting polypharmacology for improving therapeutic outcome of kinase inhibitors (KIs): An update of recent medicinal chemistry efforts
Keywords: Polypharmacology; Kinase inhibitors; Malignancies; Drug resistance; Anti-cancer therapeutics;
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Keywords: HIV; Co-infection; Multi-target drugs; Polypharmacology; Hybrids; Dual drugs;
Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis
Keywords: AA; arachidonic acid; ABA; 3-O-acetyl-boswellic acid; AKBA; 3-O-acetyl-11-keto-boswellic acid; BA; boswellic acid; COX; cyclooxygenase; EGCG; epigallocatechin-3-gallate; FLAP; 5-lipoxygenase-activating protein; H(P)ETE; hydro(pero)xyeicosatetraenoic acid;
Quantitative and systems pharmacology 2. In silico polypharmacology of G protein-coupled receptor ligands via network-based approaches
Keywords: GPCR; G protein-coupled receptor; EP4; prostaglandin E2 receptor EP4 subtype; LPAR; lysophosphatidic acid receptor; DTI; drug-target interaction; ADE; adverse drug event; MoA; mechanism of action; Ki; inhibition constant; Kd; dissociation constant; IC50;
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects
Keywords: Multitarget directed ligands; Polypharmacology; Designed multiple ligands; 5-HT1A partial agonist; 5-HT7 antagonist; Dopamine D2 receptors; Schizophrenia; Cognitive flexibility;
Synthesis and evaluation of novel dual BRD4/HDAC inhibitors
Keywords: BET bromodomain; BRD4; HDAC; Benzoyladenine; Structure-activity relationship; Polypharmacology;
Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors
Keywords: TAK1; Polypharmacology; Multitarget; Cancer; Cytokine secretion;
The influence of 5-HT2A activity on a 5-HT2C specific in vivo assay used for early identification of multiple acting SERT and 5-HT2C receptor ligands
Keywords: Polypharmacology; Designed multiple ligand (DML); Serotonin reuptake inhibitor (SRI); 5-HT2C antagonist; Serotonin antagonist and reuptake inhibitor (SARI)
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands
Keywords: Polypharmacology; Multitarget directed ligands; Designed multiple ligands; Serotonin 5-HT6 receptors; Dopamine D2/D3 receptors; Histamine H3 receptors;
ReviewNetwork pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
Keywords: Eleutherococcus senticosus; Genomics; Green tea polyphenolics; Lithospermum erythrorhizon; Metabolomics; Polypharmacology; Proteomics; Rhodiola rosea; Schisandra chinensis; Synthetic lethality; Systems biology; Transcriptomics;
Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists
Keywords: G protein-coupled receptors; Dopamine receptor; β2 adrenergic receptor; Neurodegenerative disorders; Parkinson's disease; Molecular probes; Polypharmacology;
8-Substituted 1,3-dimethyltetrahydropyrazino[2,1-f]purinediones: Water-soluble adenosine receptor antagonists and monoamine oxidase B inhibitors
Keywords: Alzheimer's disease; Anellated xanthines; Caffeine derivatives; Heterocycles; Neurodegenerative disease; Polypharmacology; Parkinson's disease: synthesis; Water-solubility; Xanthines;
Invited perspectiveThe renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the “Triad of Death” in cancer by Di-2-pyridylketone thiosemicarbazones
Keywords: Polypharmacology; Metastasis; Tumor growth; Resistance; Thiosemicarbazones; DpC;
Multiple binding sites in the nicotinic acetylcholine receptors: An opportunity for polypharmacolgy
Keywords: Nicotinic receptor; Polypharmacology; Medicinal chemistry; Drug design; Orthosteric ligands; Allosteric ligands
The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration
Keywords: Rho kinase; MRCK; Cell migration plasticity; ROCK and MRCK inhibitors; Anticancer therapeutics; Polypharmacology;
Design, synthesis and characterization of dual inhibitors against new targets FabG4 and HtdX of Mycobacterium tuberculosis
Keywords: Tuberculosis; FabG4; HtdX; MIC; Biofilm; Polypharmacology
John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors
Keywords: GPCR; Medicinal chemistry; Purines; X-ray structures; Nucleosides; Nucleotides; Polypharmacology
Potential synergistic effects of Chinese herbal prescription FTZ components detected in blood towards hepatic lipid-modulating targets
Keywords: TCM; traditional Chinese medicine; UPLC/Q-TOF-MS; ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry; RC; Rhizoma Coptidis; RSM; Radix Salvia Miltiorrhiza; TC; total cholesterol; TG; total triglyceride; LDL-C; low density l
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy
Keywords: PARP; Polypharmacology; Molecular dynamics; Fluorescence anisotropy; Cancer; Neuroprotection
ReviewSystems biology, complexity, and the impact on antiepileptic drug discovery
Keywords: Systems biology; Systems/network pharmacology; Drug resistance in epilepsy; Antiepileptic drug; Polypharmacology; Multitarget drug; Phenotypic screening; Modeling; Drug discovery;
Polypharmacology rescored: Protein-ligand interaction profiles for remote binding site similarity assessment
Keywords: Fingerprints; Profiling; Binding site similarity; Drug repositioning; Polypharmacology; Protein-ligand interactions;
Network-based target ranking for polypharmacological therapies
Keywords: Polypharmacology; PPI network; Network-based bioinformatics; Drug discovery; Target ranking;
Amelioration of Danhong injection on the lipopolysaccharide-stimulated systemic acute inflammatory reaction via multi-target strategy
Keywords: Salvia miltiorrhiza; Carthamus tinctorius; Systemic inflammatory response syndrome; Anti-inflammatory; Polypharmacology; Traditional Chinese medicine (TCM);
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology
Keywords: Telomerase; Imidazole-fused anthraquinones; TRAP assay; SEAP assay; Polypharmacology
Troubleshooting and deconvoluting label-free cell phenotypic assays in drug discovery
Keywords: Drug residence time; Label-free cell phenotypic assay; Ligand-directed functional selectivity; Network pharmacology; Phenotypic pharmacology; Polypharmacology
Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus
Keywords: Type II diabetes; Network analysis; Virtual screening; Traditional Chinese Medicine; Drug-target network; Polypharmacology;
Research reportFerulic acid-induced anti-depression and prokinetics similar to Chaihu-Shugan-San via polypharmacology
Keywords: Ferulic acid; Anti-depression; Prokinetics; Polypharmacology; Traditional Chinese medicine;
Synthesis, spasmolytic activity and structure–activity relationship study of a series of polypharmacological thiobenzanilides
Keywords: Thiobenzanilide derivatives; Spasmolytic activity; Polypharmacology; Structure–activity relationship
From in silico target prediction to multi-target drug design: Current databases, methods and applications
Keywords: Target prediction; Polypharmacology; Mode of action; Target fishing; In silico; Off targets;
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
Keywords: Pyridyl-phenyl ether; 5-HT reuptake; NA reuptake; Lipophilicity; Polypharmacology; Off-target promiscuity