Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus

► The action mechanism of Tangminling Pills which was effective for relieving T2DM was elucidated by virtual screening and network analysis. ► Multiple active compounds would target multiple proteins to influence the whole biological network. ► Five novel compounds which were unknown to be associated with T2DM were highlighted. ► The association between active compounds, target proteins and diseases was discussed. ► Network analysis was powerful to describe the importance of each node.