دانلود مقالات ISI درباره polyQ، polyglutamine + ترجمه فارسی

Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1

Keywords: polyQ، polyglutamine; 3D, three-dimensional; DLS, dynamic light scattering; Fab, fragment antigen-binding; HD, Huntington's disease; MALS, multiangle light scattering; polyQ, polyglutamine; SAXS, small-angle X-ray scattering; SEC, size-exclusion chromatography; SSRL, Stanford

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

A comprehensive glycome profiling of Huntington's disease transgenic mice

Keywords: polyQ، polyglutamine; HD, Huntington's disease; CDG, congenital disorders of glycosylation; CNS, central nervous system; GSL-omics, glycosphingolipidomics; PolyQ, polyglutamine; TCEP, Tris(2-carboxyethyl) phosphine hydrochloride; MeOH, methanol; ConA, Canavalia ensiformis; LCA

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors

Keywords: polyQ، polyglutamine; SIRT2; Huntington's disease; 3-(Benzylsulfonamido)benzamides; Polyglutamine aggregation; ADMECNS, central nervous system; HD, Huntington's disease; HDAC, histone deacetylase; SIRT2, sirtuin-2; PolyQ, polyglutamine

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism

Keywords: polyQ، polyglutamine; PolyQ, polyglutamine; VCD, vibrational circular dichroism; DUVRR, deep UV resonance Raman; IR, infrared; AFM, atomic force microscopy; EM, electron microscopy; H/D, hydrogen-deuteriumPolyglutamine; PolyQ; Fibril aggregate; Chirality; Vibrational circular

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

Keywords: polyQ، polyglutamine; AD, Alzheimer's disease; HSF1, heat shock factor 1; HSPs, heat shock proteins; HSP60, heat shock protein 60; HSP70, heat shock protein 70; HSP90, heat shock protein 90; LV, lentivirus vector; PolyQ, polyglutamine; SCAs, spinocerebellar ataxiasAlzheimer's

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

CCG polymorphisms in the huntingtin gene have no effect on the pathogenesis of patients with Huntington's disease in mainland Chinese families

Keywords: polyQ، polyglutamine; HD, Huntington's disease; polyQ, polyglutamine; htt, huntingtin(protein); HTT, huntingtin(gene); HEK293T, human embryonic kidney 293T cells; PCR, polymerase chain reaction; GFP, green fluorescent protein; DMEM, Dulbecco's modified Eagle's medium; FBS, fet

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin

Keywords: polyQ، polyglutamine; HD, Huntington’s disease; polyQ, polyglutamine; tNhtt, truncated N-terminal huntingtin; RyR, ryanodine receptor; IP3R, inositol 1,4,5-triphosphate receptors; Dan, dantrolene; RR, ruthenium red; Ry, ryanodine; DHBP, 1,1′-diheptyl-4, 4′-bipyridinium dibromi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

SCA1—Phosphorylation, a regulator of Ataxin-1 function and pathogenesis

Keywords: polyQ، polyglutamine; Akt, AKR mouse thymoma kinase; ATXN1, vascular endothelial growth factor human Ataxin-1; dox, doxycycine; NLS, nuclear localization sequence; PKA, cyclic AMP-dependent protein kinase; polyQ, polyglutamine; RBM17, RNA binding motif protein 17; SCA1, Spinoc

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Propagation of the Prion Phenomenon: Beyond the Seeding Principle

Keywords: polyQ، polyglutamine; ALS, amyotrophic lateral sclerosis; SOD1, superoxide dismutase 1; TDP-43, TAR DNA-binding protein 43; polyQ, polyglutamine; GFP, green fluorescent proteinamyloid; prion; prion-like; aggregation; neurodegenerative diseases

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Tissue transglutaminase overexpression does not modify the disease phenotype of the R6/2 mouse model of Huntington's disease

Keywords: polyQ، polyglutamine; HD, Huntington's disease; htt, huntingtin; polyQ, polyglutamine; TG2, tissue transglutaminase; WT, wild type; MSN, medium spiny neuronHuntington's disease; Transglutaminase; Mouse model; Phenotype; Modifiers; Aggregates

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

Keywords: polyQ، polyglutamine; polyQ, polyglutamine; htt, huntingtin; wt, wild type; HA, hemagglutinin; IP, immunoprecipitation; PDB, Protein Data Bank; CDR, complementarity-determining region; SAXS, small-angle X-ray scattering; Cer, Cerulean fluorescent protein; MBP, maltose binding

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Physical Chemistry of Polyglutamine: Intriguing Tales of a Monotonous Sequence

Keywords: polyQ، polyglutamine; polyQ, polyglutamine; HD, Huntington's disease; htt, huntingtin; FCS, fluorescence correlation spectroscopy; httNT, htt 17-amino acid N-terminus; AUC, analytical ultracentrifugation; GFP, green fluorescent protein; FTIR, Fourier transform infrared spectro

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2012 سفارش ترجمه

Both plant and animal LEA proteins act as kinetic stabilisers of polyglutamine-dependent protein aggregation

Keywords: polyQ، polyglutamine; LEA, late embryogenesis abundant; PBS, phosphate-buffered saline; IDP, intrinsically disordered protein; EGFP, enhanced green fluorescent protein; GST, glutathione transferase; ThT, thioflavin T; polyQ, polyglutamine; FRET, Förster resonance energy transf

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Genetic ablation and chemical inhibition of IP3R1 reduce mutant huntingtin aggregation

Keywords: polyQ، polyglutamine; HD, Huntington’s disease; polyQ, polyglutamine; htt, huntingtin; IP3, inositol 1,4,5-trisphosphate; IP3R1, IP3 receptor type 1; 2-APB, 2-aminoethyl diphenylborinate; ER, endoplasmic reticulum; MSN, medium spiny neurons; Neuro2a cells, mouse neuroblastoma

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

The structure of two CONSTANS-LIKE1 genes in potato and its wild relatives

Keywords: polyQ، polyglutamine; CBF, CCAAT-binding factor; CO, CONSTANS; COL, CONSTANS-LIKE; DN, day-neutral; FT, FLOWERING LOCUS T; LD, long day; MR, middle region of CONSTANS protein; NF-Y, Nuclear Factors Y; NJ, Neighbor Joining; polyN, polyasparagine; polyQ, polyglutamine; SD, short

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

Keywords: polyQ، polyglutamine; CJD, Creutzfeldt–Jakob disease; AD, Alzheimer's disease; PD, Parkinson's disease; HD, Huntington's disease; Aβ, amyloid-β; polyQ, polyglutamine; CNS, central nervous system; NFTs, neurofibrillary tangles; NTs, neuropil threads; APP, amyloid precursor prot

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

SCA17 repeat expansion: Mildly expanded CAG/CAA repeat alleles in neurological disorders and the functional implications

Keywords: polyQ، polyglutamine; AD, Alzheimer's disease; PD, Parkinson's disease; HSPA5, heat shock 70 kDa protein 5; HSPA8, heat shock 70 kDa protein 8; HSPB1, heat shock 27 kDa protein 1; PARK7, Parkinson's disease 7; polyQ, polyglutamine; SCA17, spinocerebellar ataxia type 17; TBH, t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Altered expression of HSPA5, HSPA8 and PARK7 in spinocerebellar ataxia type 17 identified by 2-dimensional fluorescence difference in gel electrophoresis

Keywords: polyQ، polyglutamine; 2D-DIGE, two-dimensional difference in gel electrophoresis; HSPA5, heat shock 70 kDa protein 5; HSPA8, heat shock 70 kDa protein 8; IPG, immobilized pH gradient; PARK7, Parkinson disease 7; PMF, peptide mass fingerprinting; polyQ, polyglutamine; SCA17, sp

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells

Keywords: polyQ، polyglutamine; CF, climbing fiber; EPSC, excitatory postsynaptic current; HA, hemagglutinin; P, postnatal day; PF, parallel fiber; polyQ, polyglutamine; PPD, paired-pulse depression; PPF, paired-pulse facilitation; SCA, spinocerebellar ataxiaPolyglutamine; Purkinje cell

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Molecular dynamics simulation study on the structural stabilities of polyglutamine peptides

Keywords: polyQ، polyglutamine; polyQ, polyglutamine; MD, molecular dynamics; MOE, Molecular Operating Environment; PBC, periodic boundary condition; RMSD, root mean square deviationPolyglutamine; Huntington's disease; Protein aggregation; β-Helix; Molecular dynamics

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Pathogenic and Non-pathogenic Polyglutamine Tracts Have Similar Structural Properties: Towards a Length-dependent Toxicity Gradient

Keywords: polyQ، polyglutamine; polyQ, polyglutamine; GST, glutathione S-transferase; Qn, polyQ of n residus; SPR, surface plasmon resonance; HSQC, hetero single quantum coherence; ESI-TOF, mass spectrometric electrospray ionization-time of flight; Fab, antigen binding fragment; RU, rel

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Interactions with Diverse Intermediates

Keywords: polyQ، polyglutamine; AS, α-synuclein; Hsp, heat shock protein; PreAS, prefibrillar AS; PD, Parkinson's disease; Hsp70s, heat shock protein 70 family members; polyQ, polyglutamine; ThT, Thioflavin T; EM, electron microscopyα-synuclein; fibril; intermediate; heat shock protein

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه