دانلود مقالات ISI درباره متابولیسم ضعیف + ترجمه فارسی

کودکان چاق نیاز دوزهای پایین پانتوپراازول از همسالان غیرمعمول برای دستیابی به اثرات جانبی سیستماتیک برابر دارند

Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Keywords: متابولیسم ضعیف; pharmacokinetics; obesity; pediatrics; proton pump inhibitors; AE; Adverse event; AUC; Area under the concentration time curve; AUCinf; AUC from time zero to infinity; AUClast; AUC from time zero to the time of the last measurable concentration; BMI; Body

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

تلاش خودکشی مرگبار با مسمومیت مخلوط متپرولول و پروپوفنون - اولین پرونده در مورد کودکان

Lethal suicide attempt with a mixed-drug intoxication of metoprolol and propafenone - A first pediatric case report

Keywords: متابولیسم ضعیف; Cl; clearance; CYP; cytochrome P450; ECG; electrocardiogram; ECMO; extracorporeal membrane oxygenation; EM; extensive metabolizer; ICU; intensive care unit; IM; intermediate metabolizer; MR; metabolic ratio; PM; poor metabolizer; t1/2; elimination half-li

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

تغییرات ژنی در پاسخ به کلوپیدوگرل هیچ تاثیری بر نتایج بالینی بیماران چینی تحت مداخله عروق کرونر ندارد - مطالعه چند محوری

Gene variants in responsiveness to clopidogrel have no impact on clinical outcomes in Chinese patients undergoing percutaneous coronary intervention - A multicenter study

Keywords: متابولیسم ضعیف; ACS; acute coronary syndrome; PCI; percutaneous coronary intervention; DNA; deoxyribonucleic acid; SNPs; single nucleotide polymorphisms; CV death; cardiovascular death; MI; myocardial infarction; EM; extensive metabolizer; IM; intermediate metabolizer; P

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

راهنمای فارماکوکینتیک فارماکوهنژیک برای داروهای ضد افسردگی: یک الگو برای پزشکی دقیق روانپزشکی

Pharmacokinetic Pharmacogenetic Prescribing Guidelines for Antidepressants: A Template for Psychiatric Precision Medicine

Keywords: متابولیسم ضعیف; AUC; area under the curve; CPIC; Clinical Pharmacogenetics Implementation Consortium; CYP; cytochrome P450; EM; extensive metabolizer; FDA; US Food and Drug Administration; OCD; obsessive-compulsive disorder; PM; poor metabolizer; QIDS-C16; Quick Inventor

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Is CYP2D6 phenotype predictable from CYP2D6 genotype?

Keywords: متابولیسم ضعیف; CNV; copy number variation; CYP; cytochrome P450; EM; extensive metabolizer; IM; intermediate metabolizer; PCR; polymerase chain reaction; PM; poor metabolizer; SNP; single nucleotide polymorphism; UM; ultra-rapid metabolizer; CYP2D6 genotype; Genetic pol

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

CYP2D6 (C2850T, G1846A, C100T) polymorphisms, haplotypes and MDR analysis in predicting coronary artery disease risk in north-west Indian population: A case-control study

Keywords: متابولیسم ضعیف; μl; microlitre; A; adenine; BMI; body mass index; bp; basepair; C; cytosine; CAD; coronary artery disease; CI; confidence intervals; CNS; central nervous system; CVC; cross validation consistency; CYP2D6; cytochrome P450 2D6; EDTA; ethylenediaminetetra a

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

Combination of CYP2C19 genotype with non-genetic factors evoking phenoconversion improves phenotype prediction

Keywords: متابولیسم ضعیف; CAR; constitutive androstane receptor; CI; confidence interval; CYP; cytochrome P450; EM; extensive metabolizer; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GR; glucocorticoid receptor; IM; intermediate metabolizer; PCR; polymerase chain reaction; PM

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics

Keywords: متابولیسم ضعیف; ADH; alcohol dehydrogenase; CDC; Centers for Disease Control and Prevention; CYP; cytochrome P450; del; deletion; EDDP; 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine; EM; extensive metabolizer; EMDP; 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline; FDA; Food and

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Optimization of maintenance therapy of Risperidone with CYP2D6 genetic polymorphisms through an extended translational framework-based prediction of target occupancies/clinical outcomes

Keywords: متابولیسم ضعیف; RO; receptor occupancy; EPS; extrapyramidal symptoms; PK; pharmacokinetic; PD; pharmacodynamic; EM; extensive metabolizer; IM; intermediate metabolizer; PM; poor metabolizer; PBPKPD; physiology-based pharmacokinetic and pharmacodynamic; P-gp; P-glycoprote

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Detection of CYP2D6 polymorphism using Luminex xTAG technology in autism spectrum disorder: CYP2D6 activity score and its association with risperidone levels

Keywords: متابولیسم ضعیف; CYP2D6; Luminex; Activity score; Risperidone; Autism spectrum disorder; CYP2D6; Cytochrome P450 2D6; PM; poor metabolizer; IM; intermediate metabolizer; EM; extensive metabolizer; UM; ultra-rapid metabolizer; ASD; autism spectrum disorder; F; function; DF

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Preoperative CYP2D6 metabolism-dependent β-blocker use and mortality after coronary artery bypass grafting surgery

Keywords: متابولیسم ضعیف; 16; 23.1; BB; β-blocker; CABG; coronary artery bypass grafting; CI; confidence interval; EuroSCORE; European System for Cardiac Operative Risk Evaluation score; IPW; inverse probability weighting; OR; odds ratio; PM; poor metabolizer;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Polymorphisms and phenotypic analysis of cytochrome P450 2D6 in the Tibetan population

Keywords: متابولیسم ضعیف; bp; base pair(s); CYP; cytochrome P450; DNA; deoxyribonucleic acid; EM; extensive metabolizer; LD; linkage disequilibrium; LOD; log odds score; MAF; minor allele frequency; min; minute; PCR; Polymerase Chain Reaction; PM; poor metabolizer; s; second; SNP;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Association of CYP2C19 Polymorphisms and Lansoprazole-Associated Respiratory Adverse Effects in Children

Keywords: متابولیسم ضعیف; CYP; Cytochrome P450; EM; Extensive metabolizer; PM; Poor metabolizer; PPI; Proton pump inhibitor; SNP; Single nucleotide polymorphism; ST; Sore throat; URI; Upper respiratory tract infection; WT; Wild type;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Keywords: متابولیسم ضعیف; Biotransformation; Cytochrome P450 monooxygenase; NADPH:cytochrome P450 reductase; Pharmacogenetics; Polymorphism; Xenobiotic; ADME; absorption, distribution, metabolism, excretion; ADR; adverse drug reaction; AhR; aromatic hydrocarbon receptor; CNV; copy

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine

Keywords: متابولیسم ضعیف; CYP2D6; CYP2C19; Venlafaxine; Poor metabolizer; Drug poisoning; Mechanistic pharmacokinetic simulation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype

Keywords: متابولیسم ضعیف; Stomach; PPI; Drug Interactions; Cardiovascular; AC; aspirin and clopidogrel; ARU; aspirin reaction unit; CYP2C19; S-mephenytoin 4′-hydroxylase; GSRS; Gastrointestinal Symptom Rating Scale; IM; intermediate metabolizer; IPA; inhibition of platelet aggre

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Esomeprazole With Clopidogrel Reduces Peptic Ulcer Recurrence, Compared With Clopidogrel Alone, in Patients With Atherosclerosis

Keywords: متابولیسم ضعیف; Proton-Pump Inhibitor; Plavix; CYP2C19; Drug Interactions; hetEM; heterogeneous extensive metabolizer; homEM; homogeneous extensive metabolizer; ITT; intention to treat; NSAID; nonsteroidal anti-inflammatory drug; PM; poor metabolizer; PPA; percentage of

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Treatment Considerations for Patients With Neuropathic Pain and Other Medical Comorbidities

Keywords: متابولیسم ضعیف; ADR; adverse drug reaction; BP; blood pressure; CKD; chronic kidney disease; CYP; cytochrome P450; ECG; electrocardiogram; EM; extensive metabolizer; GFR; glomerular filtration rate; MI; myocardial infarction; NP; neuropathic pain; NSAID; nonsteroidal ant

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacologic Aspects of Eradication Therapy for Helicobacter pylori Infection

Keywords: متابولیسم ضعیف; CYP2C19; Helicobacter pylori; Pharmacogenomics; Proton pump inhibitor; Rapid metabolizer; Intermediate metabolizer; Poor metabolizer;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2010 سفارش ترجمه

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes

Keywords: متابولیسم ضعیف; Cytochrome P450 3A4; P450 2C19; Poor metabolizer; NMR; LC/MS; Hydroxylation

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

The AmpliChip CYP450 Test: Principles, Challenges, and Future Clinical Utility in Digestive Disease

Keywords: متابولیسم ضعیف; ADR; adverse drug reaction; IBS-C; constipation-predominant irritable bowel syndrome; CYP450; cytochrome P450; IBS-D; diarrhea-predominant irritable bowel syndrome; EM; extensive metabolizer; GERD; gastroesophageal reflux disease; IBS; irritable bowel syn

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Gastroduodenal Disease, Helicobacter pylori, and Genetic Polymorphisms

Keywords: متابولیسم ضعیف; cagPAI; cag pathogenicity island; DU; duodenal ulcer; EM; extensive metabolizer; HLA; human leukocyte antigen; iceA; induced by contact with epithelium; IL; interleukin; MHC; major histocompatibility complex; PM; poor metabolizer; PPI; proton pump inhibit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Influence of CYP2C19 Polymorphism and Helicobacter pylori Genotype Determined From Gastric Tissue Samples on Response to Triple Therapy for H pylori Infection

Keywords: متابولیسم ضعیف; CI; confidence interval; 13C-UBT; 13C-urea breath test; CYP2C19; S-mephenytoin 4′-hydroxylase; DU; duodenal ulcer; GU; gastric ulcer; IM; intermediate metabolizer; MALT; mucosa-associated lymphoid tissue; MIC; minimum inhibitory concentration; PCR; poly

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Polymorphisms affecting gene regulation and mRNA processing: Broad implications for pharmacogenetics

Keywords: متابولیسم ضعیف; 5-FU; 5-fluorouracil; 5-HTT; serotonin transporter; 5-HTTLPR; serotonin gene-linked polymorphic region; 6-MP; 6-mercaptopurine; 6-TG; 6-thioguanine; ABCB; ATP-binding cassette (ABC), subfamily B; ACE; angiotensin I converting enzyme (peptidyl-dipeptidase

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2005 سفارش ترجمه