Keywords: PPAR، گیرنده فعال فعال پروکسیوم; NAFLD, non-alcoholic fatty liver disease; IHL, intrahepatic lymphocytes; NASH, non-alcoholic steatohepatitis; PPAR, peroxisome proliferator-activated receptor; ER, endoplasmic reticulumInterleukin-15; NAFLD; Mice; Liver; Inflammation
مقالات ISI PPAR، گیرنده فعال فعال پروکسیوم (ترجمه نشده)
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Keywords: PPAR، گیرنده فعال فعال پروکسیوم; AA, arachidonic acid; IBMX, 3-isobutyl-1-methylxanthine; COX, cyclooxygenase; PG, prostaglandin; PPAR, peroxisome proliferator-activated receptor; L-PGDS, lipocalin-type PGD synthase; 15d-PGJ2, 15-deoxy-Δ12,14-PGJ2; DMEM-HEPES, Dulbecco’s modified Eagle’s
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; H. Pylori, Helicobacter pylori; PPAR, Peroxisome proliferator-activated receptor; MTHF, Methyl tetrahydrofolate; MALDI ToF/ToF, Matrix assisted laser desorption ionization, Time of flight; DTT, Dithiotheritol; IAA, Iodoacetic acid; TFA, Trifluoroacetic ac
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PM, ambient particulate matter; PM2.5, PM with aerodynamic diameter less than 2.5 μm; FA, filtered air; OASIS, Ohio’s Air Pollution Exposure System for the Interrogation of Systemic Effects; PPAR, peroxisome proliferator-activated receptor; TGFβ, transfor
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; NNS, nonnutritive sweetener; DIO, diet-induced obesity; BAT, brown adipose tissue; WAT, white adipose tissue; UCP, uncoupling protein; MSL, skeletal muscle; TG, triglyceride; PPAR, peroxisome proliferator-activated receptor; PGC-1, peroxisome proliferator
Syringaresinol induces mitochondrial biogenesis through activation of PPARβ pathway in skeletal muscle cells
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR, peroxisome proliferator-activated receptor; Syr, syringaresinol; LBD, ligand binding domain; CPT1, carnitine palmitoyltransferase 1; UCP2, uncoupling protein 2; ITC, isothermal titration calorimetry; TR-FRET, time-resolved fluorescence resonance ene
Constitutive expression of PPARγ inhibits proliferation and migration of gastric cancer cells and down-regulates Wnt/β-Catenin signaling pathway downstream target genes TERT and ENAH
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; GC, Gastric cancer; PPAR, Peroxisome proliferator-activated receptor; TERT, Telomerase reverse transcriptase; ENAH, Enabled homologue; RPMI, Roswell park memorial institute; FBS, Fetal bovine serum; CCK-8, Cell counting kit-8; PCR, Polymerase chain reacti
A selective peroxisome proliferator-activated receptor δ agonist PYPEP suppresses atherosclerosis in association with improvement of the serum lipoprotein profiles in human apolipoprotein B100 and cholesteryl ester transfer protein double transgenic mice
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR, peroxisome proliferator-activated receptor; CETP, cholesteryl ester transfer protein; hApoB100/hCETP-dTg, human apolipoprotein B100 and human cholesteryl ester transfer protein double transgenic; HDL, high-density lipoprotein; LDL, low-density lipop
Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR-γ; Pioglitazone; MAPK; CDKI; MCF7CDKI, Cyclin dependent kinase inhibitor; CMC, Carboxymethyl cellulose; PPAR, Peroxisome proliferator-activated receptor; PPRE, PPAR responsive element; Pio, Pioglitazone; PD, 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopro
ZLN005 protects cardiomyocytes against high glucose-induced cytotoxicity by promoting SIRT1 expression and autophagy
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; NF-κB, nuclear factor-κB; SIRT1, silent information regulator 2 homolog 1; HG, high glucose; FoxO, forkhead box O; NAD, nicotinamide adenine dinucleotide; PPAR, peroxisome proliferator-activated receptor; PGC-1α, peroxisome proliferator-activated receptor
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR, Peroxisome proliferator-activated receptor; CB1, type 1 cannabinoid receptor; CB2, type 2 cannabinoid receptor; i.p., intraperitoneally; PTZ, pentylenetetrazole; i.v., intravenously; WIN, WIN 55,212-2 mesylate; DMSO, Dimethyl sulfoxide; NMDA, N-meth
Peroxisome proliferator-activated receptor alpha1 in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, mRNA tissue expression and transcriptional regulation by insulin in vivo and in vitro
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; BW, body weight; DBD, DNA-binding domain; FBS, fetal bovine serum; LBD, ligand-binding domain; NJ, neighbor-joining; ORF, open reading frame; PPAR, peroxisome proliferator-activated receptor; RACE, rapid amplification of cDNA ends; RT-PCR, reverse transcr
Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; HUFA, highly unsaturated fatty acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; LPL, lipoprotein lipase; PPAR, peroxisome proliferator-activated receptor; DEG, differentially expressed genes; RPKM, reads per kb per million reads; SCD, stearoyl
Bezafibrate, a peroxisome proliferator–activated receptor α agonist, decreases circulating CD14+CD16+ monocytes in patients with type 2 diabetes
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; IGT, impaired glucose tolerance; IL, interleukin; MNCs, mononuclear cells; NGT, normal glucose tolerance; PPAR, peroxisome proliferator-activated receptor; TNF, tumor necrosis factor
Optimized osteogenic differentiation protocol from R1 mouse embryonic stem cells in vitro
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; AA, ascorbic acid; Alp, alkaline phosphatase; Bmp-2, bone morphogenetic protein-2; Bsp, bone sialoprotein; B-Gly, β-Glycerolphosphate; Dex, Dexamethasone; EB, embryoid body; ESC, Embryonic stem cell; Ppar, peroxisome proliferator-activated receptor; Ocn,
Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Liver; Hepatic; Hepatokine; ExerciseFFA, free fatty acids; FGF-21, fibroblast growth factor-21; PPAR, peroxisome proliferator-activated receptor
Peroxisome proliferator-activated receptor gamma (PPARγ) in yellow catfish Pelteobagrus fulvidraco: Molecular characterization, mRNA expression and transcriptional regulation by insulin in vivo and in vitro
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; aa, amino acid; DBD, DNA-binding domain; LBD, ligand-binding domain; NJ, neighbor-joining; nt, nucleotide; ORF, open reading frame; PPAR, peroxisome proliferator-activated receptor; RACE, rapid amplification of cDNA ends; SEM, standard errors of means; UT
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Cardiomyocyte; Peroxisome proliferator-activated receptor α; Fatty acid metabolism; Cardiac metabolism; Monoubiquitination; Muscle ring finger-1MuRF1, Muscle ring finger-1; PPAR, Peroxisome proliferator-activated receptor; RXRα, RXR retinoid X receptor-α;
Structural design and synthesis of arylalkynyl amide-type peroxisome proliferator-activated receptor γ (PPARγ)-selective antagonists based on the helix12-folding inhibition hypothesis
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPARγ; PPARγ antagonist; Agonist–antagonist switching; Rational design; Helix12 folding inhibition hypothesisNR, nuclear receptor; PPAR, peroxisome proliferator-activated receptor; LBD, ligand-binding domain; H12, helix12
Δ9-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: Possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; 9-THC, 9-tetrahydrocannabinol; FA2H, fatty acid 2-hydroxylase; PPAR, peroxisome proliferator-activated receptor; PPRE, PPAR response element; CYP1A1, cytochrome P450 1A1Δ9-tetrahydrocannabinol; Fatty acid 2-hydroxylase; Peroxisome proliferator-activated r
Sequestration of fatty acids in triglycerides prevents endoplasmic reticulum stress in an in vitro model of cardiomyocyte lipotoxicity
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; ACSL1, acyl-CoA synthase 1; ATGL, adipose triglyceride lipase; DAG, diacylglycerol; ER, endoplasmic reticulum; FA, fatty acid; LD, lipid droplet; OA, oleic acid; PA, palmitic acid; PPAR, peroxisome proliferator-activated receptor; ROS, reactive oxygen spe
Identification of a naturally occurring retinoid X receptor agonist from Brazilian green propolis
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; BGP, Brazilian green propolis; FBS, fetal bovine serum; HEK, human embryonic kidney; LBD, ligand binding domain; LXR, liver X receptor; NR, nuclear receptor; PPAR, peroxisome proliferator-activated receptor; RAR, retinoic acid receptor; RXR, retinoid X re
Differential gene expression identified by RNA-Seq and qPCR in two sizes of pearl oyster (Pinctada fucata)
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; CSAD, cysteine sulfinic acid decarboxylase; GnRH, gonadotropin-releasing hormone; KEGG, Kyoto Encyclopedia of Genes and Genomes; MyD88, myeloid differentiation factor 88; P450, cytochrome P450 enzymes; PPAR, peroxisome proliferator-activated receptor; qPC
Palmitoylethanolamide in CNS health and disease
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; AE, acylethanolamide; PEA, palmitoylethanolamide; CNS, central nervous system; PPAR, peroxisome proliferator-activated receptor; BKCa, calcium-activated intermediate- and/or big-conductance potassium channels, IKCa; GABA, gamma-aminobutyric acid; OEA, ole
Classical NF-κB activation impairs skeletal muscle oxidative phenotype by reducing IKK-α expression
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; ACTB; Beta Cytoskeletal Actin; ALAS1; Delta-aminolevulinate synthase 1; ATP; Adenosine triphosphate; Ad; Adenoviral; B2M; β2m, Beta 2 microglobulin; BMI; Body mass index; COPD; Chronic obstructive pulmonary disease; CA; Constitutively active; COXIV; Cyto
Termination mechanism of CREB-dependent activation of COX-2 expression in early phase of adipogenesis
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PP1/2A, protein phosphatase 1/2A; PPAR, peroxisome proliferator-activated receptor; C/EBP, CCAAT/enhancer-binding protein; SREBP, sterol regulatory element-binding protein; PG, prostaglandin; COX, cyclooxygenase; MEK, mitogen-activated protein kinase/extr
Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; ER, estrogen receptor; ERE, estrogen response element; PPAR, peroxisome proliferator-activated receptor; PFAA, perfluoroalkyl acid; PFOA, perfluorooctanoate; PR, progesterone receptor; TFF, trefoil factorPerfluorooctanoate; Uterus; Estrogen receptor
Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; DAB, 3′3′-diaminobenzidine tetrahydrochloride; ERα, estrogen receptor α; PPAR, peroxisome proliferator-activated receptor; TEB, terminal end buds; VLCFA, very long chain fatty acids; WAP, whey acidic protein; TBA-RS, thiobarbituric acid-reactive substance
Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: Modulation by peroxisome proliferator-activated receptor γ agonists
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; CXCL, chemokine C–X–C motif ligand; CXCR, CXC chemokine receptor; IFN, interferon; Th, T-helper; AITD, autoimmune thyroid disorders; TNF, tumor necrosis factor; PPAR, peroxisome proliferator-activated receptor; RGZ, rosiglitazone; ANOVA, analysis of varia
Tissue-specific transcriptional modulation of fatty acid-binding protein genes, fabp2, fabp3 and fabp6, by fatty acids and the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio)
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; FA, fatty acid; FABP, mammalian fatty acid-binding protein; FABP, mammalian fatty acid-binding protein gene; Fabp, fish fatty acid-binding protein; fabp, fish fatty acid-binding protein gene; PPAR, peroxisome proliferator-activated receptor; PPRE, peroxis
Pomegranate and type 2 diabetes
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; NF-κB, nuclear factor κB; ROS, reactive oxygen species; PFE, pomegranate flower extract; PPAR, peroxisome proliferator-activated receptor; LPO, lipid peroxidation; PON1, paraoxonase 1; TGs, triglycerides; ZDF rats, Zucker fatty diabetic rats; STZ rats, st
Activation of peroxisome proliferator-activated receptor-α (PPARα) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR, peroxisome proliferator-activated receptor; TG, triacylglyceride; WAT, white adipose tissue; HFD, high fat diet; ACS, acyl-CoA synthase; CPT1A, carnitine palmitoyl-transferase 1A; AOX, acyl-CoA oxidase; GPAT, glycerol-3-phosphate acyltransferase; MG
Differential sensitivities of the vascular KATP channel to various PPAR activators
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; DM2, Type-2 diabetes mellitus; KATP, ATP-sensitive K+; Kir, inwardly rectifying potassium channel; PPAR, peroxisome proliferator-activated receptor; SUR, sulfonylurea receptor; TZDs, thiazolidinediones; VSM, vascular smooth musclesPPAR; Thiazolidinedione;
Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Amacr, α-methylacyl-CoA racemase; FXR, farnesoid X receptor; IBAT, ileal bile acid transporter (known also as the sodium-dependent bile acid transporter ASBT); LXR, liver X receptor; PPAR, peroxisome proliferator-activated receptor; CDCA, chenodeoxycholic
The switch role of the Tmod4 in the regulation of balanced development between myogenesis and adipogenesis
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Tmod, Tropomodulin; MEF2, myocyte enhancer factor 2A; C/EBP, CCAAT/enhancer binding protein (C/EBP); MyoD, myoblast determination protein; PPAR, peroxisome proliferator-activated receptor; ESTs, expressed sequence tags; PCR, polymerase chain reaction; RAC
Testosterone deficiency induces markedly decreased serum triglycerides, increased small dense LDL, and hepatic steatosis mediated by dysregulation of lipid assembly and secretion in mice fed a high-fat diet
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; T, testosterone; AR, androgen receptor; HFD, high-fat diet; SD, standard diet; ORX, orchiectomized; SHAM, sham-operated; PPAR, peroxisome proliferator-activated receptor; SREBP-1, sterol regulatory element-binding protein 1; DGAT-2, diacylglycerol acyltra
Discovering small molecules that inhibit adipogenesis and promote osteoblastogenesis: Unique screening and Oncostatin M-like activity
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; MSC, mesenchymal stem cell; OSM, Oncostatin M; IL-6, Interleukin-6; IL-11, Interleukin-11; LIF, leukemia inhibitory factor; GSK, glycogen synthase kinase; ALP, alkaline phosphatase; PPAR, peroxisome proliferator-activated receptor; Runx, runt-related tran
Genetic ablation of carotene oxygenases and consumption of lycopene or tomato powder diets modulate carotenoid and lipid metabolism in mice
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; CMO-I, carotene-15,15′-monooxygenase; CMO-II, carotene-9′,10′-monooxygenase; IGF-1, insulin-like growth factor 1; mRNA, messenger RNA; PPAR, peroxisome proliferator-activated receptor; RXR, retinoid X receptor; SNP, single nucleotide polymorphism; WT, wil
The next generation of disease risk: Are the effects of prenatal nutrition transmitted across generations? Evidence from animal and human studies
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Intergenerational programming; Transgenerational programming; Developmental programming; Epigenetics; MetabolismBMI, body mass index; DMR, differentially methylated region; F, filial generation; PPAR, peroxisome proliferator-activated receptor
Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; SNPs, single nucleotide polymorphisms; PPAR, peroxisome proliferator-activated receptor; J-MICC Study, Japan Multi-institutional Collaborative Cohort Study; PGC-1α, PPARγ coactivator 1-alpha; POF, premature ovarian failure; HWE, Hardy–Weinberg equilibrium
Molecular characterization and transcriptional analysis of fad24 in pigs
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Fad24, factor for adipocyte differentiation factor 24; MSC, mesenchymal stem cell; MCE, mitotic clonal expansion; KLF, Krüppel-like factor; C/EBP, CCAAT/enhancer-binding protein; PPAR, peroxisome proliferator-activated receptor; SREBP, sterol regulatory e
Thiacremonone, a sulfur compound isolated from garlic, attenuates lipid accumulation partially mediated via AMPK activation in 3T3-L1 adipocytes
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; Thia, thiacremonone; PPAR, peroxisome proliferator-activated receptor; AMPK, adenosine 5′-phosphate-activated protein kinase; C/EBP, CCAAT/enhancer binding protein; aP2, adipocyte fatty acid binding protein; FAS, fatty acid synthase; ACC, acetyl CoA carbo
Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ12-PGJ2 acting through PPARγ-dependent and independent pathways
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; PPAR, peroxisome proliferator-activated receptor; PG, prostaglandin; L-PGDS, lipocalin-type PGD synthase; 15d-PGJ2, 15-deoxy Δ12,14-PGJ2; DMEM, Dulbecco's modified Eagle's medium; TBP, TATA-binding protein; N.C., negative control; SCD, stearoyl-CoA desatu
Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; BP, bisphenol; ER, estrogen receptor; ERR, estrogen-related receptor; 25-HC, 25-hydroxycholesterol; LBD, ligand-binding domain; LBP, ligand-binding pocket; PPAR, peroxisome proliferator-activated receptor; RORγ, retinoid-related orphan receptors γEndocrin
Differential susceptibility to the PPAR-γ agonist pioglitazone in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine rodent models of Parkinson's disease
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; MAO-B, monoamine oxidase-B; PPAR, peroxisome proliferator-activated receptor; SNc, substantia nigra pars compacta; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 6-OHDA, 6-hydroxydopamine; VTA, ventral tegmental area; TH, tyrosine hydroxylasePPAR; Pi
Full and partial peroxisome proliferation-activated receptor-gamma agonists, but not delta agonist, rescue of dopaminergic neurons in the 6-OHDA Parkinsonian model is associated with inhibition of microglial activation and MMP expression
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; HPLC-ECD, High performance liquid chromatography-Electrochemical detection; 6-OHDA, 6-hydroxydopamine; mfb, medial forebrain bundle; PD, Parkinson's disease; SNc, substantia nigra pars compacta; PPAR, Peroxisome proliferator-activated receptor; MMP, matri
Development of docking-based 3D-QSAR models for PPARgamma full agonists
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; LBD, ligand binding domain; PPAR, peroxisome proliferator-activated receptor; QSAR, quantitative structure–activity relationship; SAR, structure–activity relationship; TZDs, thiazolidinedionesPPARgamma agonists; 3D-QSAR; Antidiabetics; Drug design; Protei
Citrate carrier promoter is target of peroxisome proliferator-activated receptor alpha and gamma in hepatocytes and adipocytes
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; ChIP, chromatin immunoprecipitation; CiC, citrate carrier; DR, direct repeat; PPAR, peroxisome proliferator-activated receptor; PPRE, PPAR response element; PUFA, polyunsaturated fatty acids; RXR, retinoid X receptorAdipogenesis; Citrate carrier; Lipogene
Peroxisomal acyl-CoA synthetases
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; AA, Arachidonic acid (C20:4ω6); ACS, Acyl-CoA synthetase; CoA, Coenzyme A; FA, Fatty acid; FATP, Fatty acid transport protein; PGE2, Prostaglandin E2; PPAR, Peroxisome proliferator-activated receptor; VLCFA, Very long-chain fatty acidPeroxisome; Acyl-CoA
Nonlinear dimensionality reduction and mapping of compound libraries for drug discovery
Keywords: PPAR، گیرنده فعال فعال پروکسیوم; 2D, two-dimensional; 3D, three-dimensional; PCA, principle component analysis; PDB, Protein Data Bank; PPAR, peroxisome proliferator-activated receptor; QSAR, quantitative structure–activity relationship; SNE, stochastic neighbor embedding; SOM, self-orga