Keywords: Nuclear receptors; PPARδ; Structure-activity relationship (SAR); ADMET; PK;
مقالات ISI (ترجمه نشده)
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Keywords: AMPK; OGT; PPARδ; SIRT3; TXNIP;
Keywords: Circadian clock; Human; Serum metabolome; Skeletal muscle metabolome; High fat diet; High carbohydrate diet; 18S rRNA; 18S ribosomal RNA; ANOVA; analysis of variance; BHBA; β-hydroxybutyric acid; BMI; body mass index; Bmal1; brain and muscle ARNT-Like 1;
Keywords: PASI; Psoriasis Area and Severity Index; IL; interleukin; fzd; frizzled receptors; IFN; interferon; ADAM; a disintegrin and metalloproteinase; EGF; epidermal growth factor; TGF; transforming growth factor; TPA; 12-o-tetradecanoyl phorbol-13-acetate; VEGF;
Keywords: 4-HDDE; 4-Hydroxy-2E,6Z-dodecadienal; 4-HHE; 4-Hydroxyl-2E-hexenal, 4-HNE, 4-Hydroxy-2E-nonenal; AGE; Advanced glycation end products; ALE; Advanced lipoxidation end products; AR; aldose reductase; COX; Cyclooxygenase; EET; Epoxyeicosatrienoic acid; ER; E
Keywords: Obesity; Osteoporosis; Bone marrow fat; Inflammation; Fracture; 25OHD; 25-hydroxyvitamin D; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; BAT; brown adipose tissue; BMD; bone mineral density; BMAT; bone marrow adipose tissue; BMI; body ma
Keywords: Beta cells; Diabetes; Eicosanoids; Fatty aldehyde dehydrogenase; Glutathione peroxidase; Glutathione-S-transferase4-hydroxyalkenals; 4-Hydroxynonenal; Lipid peroxidation; Phospholipase A; 12-HETE (PubChem CID: 5283155); 15-HETE (PubChem CID: 280724); 4-HN
Naoxintong restores collateral blood flow in a murine model of hindlimb ischemia through PPARδ-dependent mechanism
Keywords: NXT; naoxintong; PAD; peripheral vascular disease; DVT; deep veins thrombus of lower limb; VEGF; vascular endothelial growth factor; p-Akt; phosphorylated-Akt; p-eNOS; phosphorylated-endothelial nitric oxide synthase; TUNEL; Terminal deoxynucleotidyl tran
4-Hydroxyalkenal-activated PPARδ mediates hormetic interactions in diabetes
Keywords: Beta cells; Diabetes; 4-Hydroxyalkenals; Lipid peroxidation; Lipohormesis; Lipotoxicity; PPARδ; Vascular endothelial cells;
Peroxisome proliferator-activated receptor δ improves porcine blastocyst hatching via the regulation of fatty acid oxidation
Keywords: Embryonic development; Pparδ; Hatching; ATP; Fatty acid oxidation;
Regulator of G protein signaling 2 (Rgs2) regulates neural crest development through Pparδ-Sox10 cascade
Keywords: Rgs2; Pparδ; Sox10; Neural crest; Zebrafish;
Polysaccharides from Cyclocarya paliurus: Chemical composition and lipid-lowering effect on rats challenged with high-fat diet
Keywords: CPP; Cyclocarya paliurus polysaccharides; HFD; high fat diet; VAT; visceral adipose tissue; TC; total cholesterol; TG; triglycerides; LDL-C; low-density protein cholesterol; HDL-C; high-density protein cholesterol; GLU; glucose concentration; FAS; fatty a
Dihydrosterculic acid from cottonseed oil suppresses desaturase activity and improves liver metabolomic profiles of high-fat-fed mice
Keywords: Fatty acid oxidation; Desaturation; Metabolomics; Bioactive lipids; Nuclear magnetic resonance (NMR) spectroscopy; 18:2; linoleic acid-rich diet; 18:2n6; linoleic acid; CHO; carbohydrate; CPFA; cyclopropyl fatty acid; CSO; cottonseed oil; DHSA; dihydros
Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway
Keywords: PN; paeonol; ER; endoplasmic reticulum; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; PPARδ; peroxisome proliferator-activated receptor δ; ACh; acetylcholine; DHE; dihydroethidium; EDR; endothelium-dependent relaxation; NO; nitric oxide
Original ResearchEffect of PPARδ Agonist on Stearoyl-CoA Desaturase 1 in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway
Keywords: PD98059; Î9-desaturase; fatty acids; GW0742; pancreatic neoplasms; PPARδ; PD98059; Î9-désaturase; acides gras; GW0742; néoplasmes pancréatiques; PPARδ;
PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells
Keywords: Docosahexaenoic acid; Epoxydocosapentaenoic acids; H9c2 cells; PPARδ; Apoptosis; Ceramide;
Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha
Keywords: IL-15; IL-15Rα; Skeletal muscle; PGC1α; PPARδ; Mitochondria;
Peroxisome proliferator-activated receptor δ modulates MMP-2 secretion and elastin expression in human dermal fibroblasts exposed to ultraviolet B radiation
Keywords: PPARδ; MMP-2; Elastin; UVB; HDFs;
Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.
Keywords: Sponge; Ircinia sp.; Sesquiterpenoids; PPARδ; Obesity;
Increase of PPARδ by dopamine mediated via DA-1 receptor-linked phospholipase C pathway in neonatal rat cardiomyocytes
Keywords: Dopamine; PPARδ; Neonatal cardiomyocytes; Phospholipase C; DA1 receptor;
Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist
Keywords: Peroxisome proliferator-activated receptor; PPARδ; PPARα; Fluorescent PPARα/δ co-agonist; Site-directed mutagenesis;
Increase of myocardial performance by Rhodiola-ethanol extract in diabetic rats
Keywords: PPARδ; peroxisome proliferator-activated receptors δ; STZ; streptozotocin; cTnI; cardiac troponin I; PPARs; peroxisome proliferator-activated receptors; RIPA; radio-immuno-precipitation assay; FA; fatty acid; Rhodiola-ethanol extract; Cardiac output;
PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway
Keywords: AP-1; activator protein-1; CNS; central nervous system; Cox-2; cyclooxygenase-2; ERK1/2; extracellular signal-related kinase 1/2; ICAM-1; intracellular cellular adhesion molecule-1; IL-1β; interleukin-1β; MCP-1; monocyte chemoattractant protein-1; MEK1/
Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice
Keywords: EMT; epithelial-mesenchymal transition; FDR; false discovery rate; FFA; free fatty acids; G6P; glucose-6-phosphotase; GcK; glucokinase; GO; gene ontology; GTT; glucose tolerance test; HDL-C; high-density lipoprotein cholesterol; HFD; high fat diet; HOMA
Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516
Keywords: GW 501516; Agonist; Fluorine; PPARα; PPARδ;
Novel biphenylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ selective antagonists
Keywords: PPAR; PPARδ; PPARδ antagonist; Biphenylcarboxylic acid;
PPARδ, but not PPARα, activates PGC-1α gene transcription in muscle
Keywords: PGC-1α; Peroxisome proliferator-activated receptor-γ coactivator-1α; PPARδ; Peroxisome proliferator-activated receptor; Skeletal muscle; PGC-1α gene promoter;
Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor α/δ dual agonists
Keywords: PPAR; PPARα; PPARδ; Metabolic syndrome;
Carcinogenesis in Mouse Stomach by Simultaneous Activation of the Wnt Signaling and Prostaglandin E2 Pathway
Keywords: APC; adenomatous polyposis coli; BrdU; bromodeoxyuridine; COX-2; cyclooxygenase-2; mPGES-1; microsomal prostaglandin E synthase-1; MVD; microvessel density; PGE2; prostaglandin E2; PPARδ; peroxisome proliferator-activated receptor δ; SPEM; spasmolytic p
A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of the phenol group by reaction with a Grignard reagent
Keywords: PPARδ; Antiobestic drug; GW501516; Grignard reagent; One-pot synthesis; Sulfide;
The peroxisome proliferator-activated receptor delta +294T/C polymorphism in relation to lipoprotein metabolism in patients with diabetes mellitus type 2 and in non-diabetic controls
Keywords: PPARδ; Atherosclerotic disease; Polymorphism;