Robust homeostasis of Presenilin1 protein levels by transcript regulation
Keywords: پرنسیلین; Presenilin; Zebrafish; Splicing; Alzheimer's disease;
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BACE1 in Alzheimer's disease
Keywords: پرنسیلین; Aβ; β-amyloid; ACDL; acid-cluster dileucine motif; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease domain protein; AICD; amyloid precursor protein intracellular domain; APLP; amyloid precursor-like protein; ApoE; apolipoprotein E; APP;
Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice
Keywords: پرنسیلین; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; DFO; defferoxamine; DA; dopamine; MAO; monoamine oxidase; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; OS; Oxidative stress; PD; Parkinson's disease; PSEN;
Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
Keywords: پرنسیلین; PIB; Amyloid; Pons; Alzheimer; Genetic; Presenilin;
Early-onset Alzheimer's Disease: Nonamnestic Subtypes and Type 2 AD
Keywords: پرنسیلین; Alzheimer's disease; Dementia; Apolipoprotein; Presenilin; Amnestic
Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice
Keywords: پرنسیلین; Oxidative stress; APP; Alzheimer's disease; TASTPM mice; BACE; presenilin;
Research ReportPresenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function
Keywords: پرنسیلین; TPC; two-pore calcium channel; NAADP; nicotinic acid adenine dinucleotide phosphate; GPN; glycyl-l-phenylalanine 2-naphthylamide; PSDKO; presenilin double knockout; Presenilin; Lysosome; Calcium; Two-pore channel; Autophagy;
Mouse models of Alzheimer's disease
Keywords: پرنسیلین; Alzheimer's disease; Amyloid-beta; Presenilin; Tau; Apolipoprotein E (ApoE); Behavior; Transgenic
Cellular mechanisms of γ-secretase substrate selection, processing and toxicity
Keywords: پرنسیلین; Alzheimer's disease; Presenilin; FAD mutations cause loss of γ-secretase activity; γ-Secretase substrate recruiting factors (γSSRFs); Metalloproteinases; ADAMs; Toxic substrates; γ-Secretase-produced signaling peptidesAβ, amyloid β peptide; AD, Alzheimer'
Identification of PSEN1 and PSEN2 gene mutations and variants in Turkish dementia patients
Keywords: پرنسیلین; Alzheimer disease; Presenilin; Mutation; Turkey;
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease
Keywords: پرنسیلین; Amyloid; Ibuprofen; Transgenic mice; Inflammation; γ-Secretase modulation; Behavior; Presenilin; Alzheimer's disease;
Central CRF system perturbation in an Alzheimer's disease knockin mouse model
Keywords: پرنسیلین; Corticotropin releasing factor; CRF; CRH; CRFR1; CRHR1; HPA axis; Alzheimer's disease; Corticosteroids; APP; Presenilin; Anxiety; Depression;
Drosophila as a model to study age-related neurodegenerative disorders: Alzheimer's disease
Keywords: پرنسیلین; Amyloid; Presenilin; Tau; Neurodegeneration; Animal models;
Endoplasmic reticulum stress enhances γ-secretase activity
Keywords: پرنسیلین; ER; endoplasmic reticulum; UPR; unfolded protein response; PS; presenilin; ATF4; activating transcription factor 4; GCN2; general control non-derepressible 2; PKR; protein kinase RNA; PERK; PKR-like ER kinase; HRI; heme-regulated inhibitor; eIF2α; eukary
Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis
Keywords: پرنسیلین; Presenilin; Gamma-secretase; Calcium; Structure-function; SCAM; Amyloid; Cotton wool plaques; Alzheimer's disease
Research ReportHydrocephalus and abnormal subcommissural organ in mice lacking presenilin-1 in Wnt1 cell lineages
Keywords: پرنسیلین; Presenilin; Conditional knockout mouse; Hydrocephalus; Ventricle; Subcommissural organ;
Zebrafish as a tool in Alzheimer's disease research
Keywords: پرنسیلین; Zebrafish; Alzheimer's disease; Presenilin
ER-stress-inducible Herp, facilitates the degradation of immature nicastrin
Keywords: پرنسیلین; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; β-amyloid precursor protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; γ-secretase; Presenilin; Nicastrin; E3 ubiquitin ligase;
Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP Ã PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis
Keywords: پرنسیلین; Alzheimer's disease; Noradrenaline; Memory; β-Amyloid; Astrocytosis; Fluparoxan; Alpha2 adrenoceptor antagonist; Aβ; β-amyloid; LC; locus coeruleus; DSP-4; N-(2-chloroethyl)-N-ethyl-bromo-benzylamine; APP; amyloid precursor protein; PS; presenilin; G
Presenilin mouse and zebrafish models for dementia: Focus on neurogenesis
Keywords: پرنسیلین; AD; Alzheimer's disease; PSEN; presenilin; APP; amyloid precursor protein; Aβ; β-amyloid; FAD; familial forms of AD; SVZ; subventricular zone; SGZ; subgranular zone; DG; dentate gyrus; NSCs; neural stem cells; DCX; doublecortin; NPC; neural progenitor c
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related γ-secretase
Keywords: پرنسیلین; Alzheimer's disease; Presenilin; γ-Secretase; APP; Aph-1
GSK3: A possible link between beta amyloid peptide and tau protein
Keywords: پرنسیلین; Alzheimer disease; Beta-amyloid peptide; ApoE4; GSK3; Presenilin; Tau
Alzheimer's secretases regulate voltage-gated sodium channels
Keywords: پرنسیلین; Alzheimer's disease; BACE1; β-Secretase; Presenilin; γ-Secretase; Voltage-gated sodium channel; Sodium channel β2-subnit;
Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells
Keywords: پرنسیلین; Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; BACE; β-site APP cleaving enzyme; sAPPα; soluble amyloid precursor protein α; HIF-1α; hypoxia-inducible factor 1α; HRE; hypoxia res
Temporal–spatial expression of presenilin 1 and the production of amyloid-β after acute spinal cord injury in adult rat
Keywords: پرنسیلین; RIP; γ-Secretase; Presenilin; Amyloid precursor protein; Amyloid-β; Spinal cord injury
Impaired TNF-α control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons
Keywords: پرنسیلین; Alzheimer's disease; β-amyloid; Tau; Presenilin; 3xTg-AD; Neuroinflammation; Calcium homeostasis;
Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis
Keywords: پرنسیلین; Alzheimer; Neurogenesis; LTP; Potentiation; Dentate gyrus; Presenilin; PS2; APP; IGF; BDNF
Anti-inflammatory treatment in AD mice protects against neuronal pathology
Keywords: پرنسیلین; A-Beta; Alzheimer's disease; Amyloid; Celecoxib; Ibuprofen; Magnetic resonance spectroscopy; Mice; Plaques; Presenilin
Association of Omi/HtrA2 with γ-secretase in mitochondria
Keywords: پرنسیلین; Omi/HtrA2; Presenilin; γ-Secretase; Mitochondria; AICD
Neurogenesis in mouse models of Alzheimer's disease
Keywords: پرنسیلین; Neural stem cell; Neurogenesis; Alzheimer's disease; Mouse model; Beta amyloid; Presenilin
CD147, a γ-secretase associated protein is upregulated in Alzheimer's disease brain and its cellular trafficking is affected by presenilin-2
Keywords: پرنسیلین; Alzheimer's disease; CD147; γ-Secretase; Human brain; Iodixanol gradient; Presenilin
Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing
Keywords: پرنسیلین; Alzheimer; beta-amyloid; presenilin; BACE; ADAM; neprilysinAβ, beta-amyloid; AD, Alzheimer's disease; APP, amyloid precursor protein; CM, cardiac muscle; IDE, insulin degrading enzyme; LI, liver; LU, lung; ME, mesencephalon; PS1, presenilin 1; PS2, presen
Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease
Keywords: پرنسیلین; Alzheimer's disease; Amyloid β; Insulin degrading enzyme; Neprilysin; Human brain; Presenilin; Astrocytes
Neurogenesis and Alzheimer's disease: At the crossroads
Keywords: پرنسیلین; Neurogenesis; Alzheimer's disease; Tau; Amyloid precursor protein; Presenilin; Stem cells; Brain plasticity; LDL receptors
Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease
Keywords: پرنسیلین; Ts65DN; Amyloid-β Precursor protein; Aβ; Presenilin; Tau; Transgenic; Lymphoma; Down's syndrome; Amyloidosis; Splenomegaly
Alzheimer’s disease and Notch signaling
Keywords: پرنسیلین; Alzheimer’s disease; Notch; Presenilin; γ-Secretase; APP; Aβ
Presenilin 1 modifies lipid raft composition of neuronal membranes
Keywords: پرنسیلین; Lipid raft; Alzheimer; Presenilin; Membrane micro-domain; γ-Secretase; Cholesterol; Membrane; Fluidity; Amyloid-precursor protein
Signal peptide peptidases: A family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins
Keywords: پرنسیلین; Intramembrane-cleaving proteases (I-CLiPs); Signal peptide peptidase (SPP); Gamma-secretase; Presenilin; Signal peptide peptidase-like (SPPL)
Over expression of amyloid beta-protein reduces the number of neurons in the striatum of APPswe/PS1ΔE9
Keywords: پرنسیلین; Amyloid beta-protein; Alzheimer's disease; Presenilin; Striatum; Neuron number
Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease
Keywords: پرنسیلین; Alzheimer's disease; Capacitative Ca2+ entry (CCE); Store operated Ca2+ entry (SOCE); Presenilin; STIM1; STIM2
Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease
Keywords: پرنسیلین; Cyclooxygenase; Presenilin; Seizures; Kainate
Presenilin: RIP and beyond
Keywords: پرنسیلین; Presenilin; Regulated intramembrane proteolysis; β-Catenin; Calcium; Apoptosis
Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos
Keywords: پرنسیلین; Presenilin; Notch; γ-secretase; Zebrafish; DoLA neurons; Melanocyte
Excitatory synaptic transmission is depressed in cultured hippocampal neurons of APP/PS1 mice
Keywords: پرنسیلین; Presenilin; Amyloid precursor protein; Alzheimer's disease; Synaptic transmission; Amyloid; Synaptic vesicle; Patch-clamp
Wnt signaling in Alzheimer's disease: Up or down, that is the question
Keywords: پرنسیلین; Wnt signaling; Alzheimer's disease; β-Catenin; GSK-3; Presenilin; Lithium
A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition
Keywords: پرنسیلین; Amyloid; Presenilin; Alzheimer's disease; Aβ deposition; Rat; Animal model; Transgenic; Reactive gliosis; Phosphorylated tau
Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism
Keywords: پرنسیلین; Alzheimer's disease; Presenilin; Extracellular regulated kinase; Protein kinase C; Phospholipase C
Enhanced oxidative stress is an early event during development of Alzheimer-like pathologies in presenilin conditional knock-out mice
Keywords: پرنسیلین; Presenilin; Oxidative stress; Malonaldehyde; Protein carbonyl; Catalase; Superoxide dismutase;
Altered oxidant-mediated intraneuronal zinc mobilization in a triple transgenic mouse model of Alzheimer’s disease
Keywords: پرنسیلین; Synaptic zinc homeostasis; Oxidative stress; 3xTg-AD; PS1KI; Presenilin; Tau; Amyloid; Alzheimer’s disease; Neuronal death
PS2 protein expression is upregulated by sex steroids in the cerebral cortex of aging mice
Keywords: پرنسیلین; Alzheimer's disease; Presenilin; Gonadectomy; 17β-Estradiol; Testosterone; Western blotting