Keywords: hepatocytes اولیه انسان; A1AT; α1-antitrypsin (A1AT); ALB; albumin; BMP-2; bone morphogenetic protein 2; BSA; bovine serum albumin; DAPI; 4',6-diamidino-2-phenylindole; BMP-4; bone morphogenic protein 4; DE; definitive endoderm; DMEM-HG; Dubelcco's modified Eagle's medium-high
مقالات ISI hepatocytes اولیه انسان (ترجمه نشده)
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Keywords: hepatocytes اولیه انسان; 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
Keywords: hepatocytes اولیه انسان; DILI; drug induced liver injury; hES-HLCs; hepatocyte-like cells derived from human embryonic stem cells; APAP; acetaminophen; TZD; thiazolidinedione; TNF; tumor necrosis factor; ÎL; interleukin; IFN; interferon; PHHs; primary human hepatocytes; hES-DE;
Keywords: hepatocytes اولیه انسان; ADH; alcohol deshydrogenase; ALDH; aldehyde deshydrogenase; CE; carboxylesterase; cis-p; cis-permethrin; CYP; cytochrome P450; DCCA; 3-(2,2 dichlorovinyl)-2,2-dimethyl-(1-cyclopropane) carboxylic acid; FBS; fetal bovine serum; PNP; 4-paranitrophenol; PNPA
Keywords: hepatocytes اولیه انسان; AMI; amiodarone; MDEA; mono-N-desethylamiodarone; DDEA; di-N-desethylamiodarone; PHH; primary human hepatocytes; CYP; cytochrome P450; DMSO; dimetylsulfoxide; MeOH; methanol; HMM; Hepatocyte Maintenance Medium; FCS; fetal calf serum; SW; sandwich; d0; day
Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction
Keywords: hepatocytes اولیه انسان; VPA; valproic acid; PHH; primary human hepatocytes; HDAC; histone deacetylase; AOP; adverse outcome pathway; MeDIP; Methylated DNA Immunoprecipitation; PSW-ANOVA; Probe Sliding Window-ANOVA; DMR; differential methylated regions; DMG; differentially methyl
Pan-Genotype Hepatitis E Virus Replication in Stem Cell-Derived Hepatocellular Systems
Keywords: hepatocytes اولیه انسان; HLCs; Antiviral; Primary Isolates; Personalized Medicine; ALB; albumin; AFP; alpha-fetoprotein; bFGF; basic fibroblast growth factor; BM; basal medium; CsA; cyclosporine A; DE; definitive endoderm; DMSO; dimethyl sulfoxide; Dox; doxycycline; ESC; embryoni
Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein
Keywords: hepatocytes اولیه انسان; Hepatitis E; PLC/PRF/5 Cells; Infectious Particles; ORF2 Products; aa; amino acid; Ag; antigen; BFA; brefeldin A; DMEM; Dulbecco's modified Eagle's medium; DT; sodium deoxycholate and trypsin treatment; ER; endoplasmic reticulum; ffu; focus forming un
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
Keywords: hepatocytes اولیه انسان; Ac-DEVD-AMC; N-acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin; AKT; protein kinase B; AMP; ampicillin; ATB; antibiotic; ATF6; activating transcription factor 6; BC; bile canaliculi; BSEP; bile salt export pump; CDF; 5(6)-carboxy-2,7-dichlorofluorescein;
Human-based systems: Mechanistic NASH modelling just around the corner?
Keywords: hepatocytes اولیه انسان; Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a
Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes
Keywords: hepatocytes اولیه انسان; Steatosis; Mitochondrial dysfunction; Primary human hepatocytes; Epigenomics; Transcriptomics; Proteomics;
A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells
Keywords: hepatocytes اولیه انسان; Micropatterned Cocultures; Tricultures; LSECs; HUVECs; 3T3-J2 Fibroblasts; CD31; cluster of differentiation 31; CD54; cluster of differentiation 54; cDNA; complementary DNA; CYP450; cytochrome P-450; ECM; extracellular matrix; F8; factor VIII; GAPDH; glyc
Critical differences in drug metabolic properties of human hepatic cellular models, including primary human hepatocytes, stem cell derived hepatocytes, and hepatoma cell lines
Keywords: hepatocytes اولیه انسان; ACN; acetonitrile; BCA; bicinchoninic acid; DMSO; dimethyl sulfoxide; ESI; electrospray ionization; HPLC; high pressure liquid chromatography; iPSC; induced pluripotent stem cell; LDA; low density array; MS; mass spectrometry; P450; cytochrome P450; PCA;
Secretion of Hepatitis C Virus Replication Intermediates Reduces Activation of Toll-Like Receptor 3 in Hepatocytes
Keywords: hepatocytes اولیه انسان; Exosomes; Escape; Virology; Rab27a; DMV; double-membrane vesicle; dsRNA; double-stranded RNA; EVs; extracellular vesicles; gt; genotype; HAV; hepatitis A virus; HCV; hepatitis C virus; HCVcc; cell culture derived HCV; IFIT1 or 3; interferon-induced protei
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of Interferon
Keywords: hepatocytes اولیه انسان; Coinfection; Interferon-stimulated Gene; PRR; RIG-I; APOBEC; apolipoprotein B mRNA editing enzyme catalytic subunit; cccDNA; covalently closed circular DNA; CHB; chronic hepatitis B; circDNA; circular DNA; GFP-IRF3; green fluorescent protein-interferon
In vitro toxicological evaluation of NCS-382, a high-affinity antagonist of γ-hydroxybutyrate (GHB) binding
Keywords: hepatocytes اولیه انسان; Cytochrome P-450 (CYP); Microsomal CYPs; PXR; Xenobiotic receptor induction; Cytotoxicity; Mitochondrial function; Apoptosis; HepG2 cells; Primary human hepatocytes; Gene expression;
Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis
Keywords: hepatocytes اولیه انسان; Cholestasis; Hepatotoxicity; Liver; HepG2; Primary human hepatocytes; Primary mouse hepatocytes;
New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine
Keywords: hepatocytes اولیه انسان; New psychoactive substances (NPS); Drugs of abuse; Metabolism; Human liver preparations; Primary human hepatocytes; LC-HR-MS/MS;
Microcystin-LR induced liver injury in mice and in primary human hepatocytes is caused by oncotic necrosis
Keywords: hepatocytes اولیه انسان; Microcystin; Apoptosis; Hepatocytes; Transporters; Necrosis; Primary human hepatocytes;
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
Keywords: hepatocytes اولیه انسان; UDPGA; 5â²-diphosphoglucuronic acid; CRMs; chemically reactive metabolites; CYP; cytochrome P450; HLM; human liver microsomes; PHH; primary human hepatocytes; UGTs; UDP-glucuronosyltransferases; β-estradiol (PubChem CID:5757); Chenodeoxycholic acid (Pub
Lipoprotein (a)
Keywords: hepatocytes اولیه انسان; familial hypercholesterolemia; LDL receptor; lipoprotein(a); PCSK9; primary human hepatocytes;
Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
Keywords: hepatocytes اولیه انسان; ABC; ATP-binding cassette transporter; AGPAT2; 1-acylglycerol-3-phosphate O-acyltransferase; AhR; arylhydrocarbon receptor; AKR1C1; aldo-keto reductase 1C1; APO; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BAs; bile acids; BSEP; b
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: hepatocytes اولیه انسان; ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Research ArticleHepatitis B virus induces RNR-R2 expression via DNA damage response activation
Keywords: hepatocytes اولیه انسان; HBV; hepatitis B virus; dNTPs; deoxyribonucleotide triphosphates; Chk1; checkpoint kinase 1; RNR; ribonucleotide reductase; DDR; DNA damage response; PHH; primary human hepatocytes; SDS-PAGE; sodium dodecyl sulfate polyacrylamide gel electrophoresis; qRT-
Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis
Keywords: hepatocytes اولیه انسان; LCA; lithocholic acid; UDCA; ursodeoxycholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic acid; CA; cholic acid; TCA; taurocholic acid; GCDC; glycochenodeoxycholic acid; TCDC; taurochenodeoxycholic acid; GCA; glycocholic acid; GDCA; glycodeoxycholi
Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment
Keywords: hepatocytes اولیه انسان; EZ; ezetimibe; RCT; reverse cholesterol transport; Abcg5/g8; Abcg5 and Abcg8; KO; knock-out; WT; wild-type; PHH; primary human hepatocytes; CDCA; chenodeoxycholic acid; BMM; bone marrow macrophages; TICE; trans-intestinal cholesterol excretion; Npc1l1; At
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: hepatocytes اولیه انسان; AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
Predictivity of dog co-culture model, primary human hepatocytes and HepG2 cells for the detection of hepatotoxic drugs in humans
Keywords: hepatocytes اولیه انسان; Hepatotoxicity; Metabolism; Chronic studies; Dog co-culture model; Primary human hepatocytes; HepG2 cells
Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes
Keywords: hepatocytes اولیه انسان; Primary human hepatocytes; HepaRG; HepG2; Gene expression; Interindividual variability;
Human Type 2 Myeloid Dendritic Cells Produce Interferon-λ and Amplify Interferon-α in Response to Hepatitis C Virus Infection
Keywords: hepatocytes اولیه انسان; IL-28B SNP; NK Cells; NKT Cells; Viral Immune Regulation; BDCA; blood DC antigen; CpG; cytosine-phosphate-guanosine; CXCL; CXC-chemokine ligand; DC; dendritic cell; dsRNA; double-strand RNA; HCV; hepatitis C virus; HCVcc; cell culture-derived hepatitis
Comparison of Culture Media for Bile Acid Transport Studies in Primary Human Hepatocytes
Keywords: hepatocytes اولیه انسان; primary human hepatocytes; bile acid transport; NTCP; BSEP; dexamethasoneDMEM, Dulbecco's Modified Eagle Medium; NTCP, sodium taurocholate cotransporting polypeptide; BSEP, bile salt export pump; OATP, organic anion-transporting polypeptide; MRP2, multidr
Biotransformation of diclofenac and effects on the metabolome of primary human hepatocytes upon repeated dose exposure
Keywords: hepatocytes اولیه انسان; Repeated dose testing; Alternative in vitro methods; Primary human hepatocytes; Drug toxicity; Drug metabolism; Metabolomics
Interferon-γ-Stimulated Genes, but Not USP18, Are Expressed in Livers of Patients With Acute Hepatitis C
Keywords: hepatocytes اولیه انسان; HCV; Jak-STAT Signaling; Host-Virus Interaction; Immune Response; AHC; acute hepatitis C; CHC; chronic hepatitis C; CHC-NR; CHC nonresponder; CHC-R; CHC responder; HCV; hepatitis C virus; HPF; high-power field; ISG; interferon-stimulated gene; JAK; Ja
Augmenter of liver regeneration (ALR) protects human hepatocytes against apoptosis
Keywords: hepatocytes اولیه انسان; rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK-1/2; extracellular signal-regulated kinase 1/2; FCS; fetal calf serum; HGF; hepatocyte growth factor; LPS; lipopolysaccharide; MAP kinase; mitogen-activated prot
The hepatitis B virus HBx protein modulates cell cycle regulatory proteins in cultured primary human hepatocytes
Keywords: hepatocytes اولیه انسان; Calcium; Cell cycle; HBx; Hepatitis B virus; Primary human hepatocytes
Research ArticleHepatitis B virus X protein is essential to initiate and maintain virus replication after infection
Keywords: hepatocytes اولیه انسان; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; PHH; primary human hepatocytes; cccDNA; covalently closed circular DNA; ChIP; chromatin immunoprecipitation; Hepatitis B virus; HBx protein; Natural infection; Primary human hepatocytes; HepaRG;
HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro
Keywords: hepatocytes اولیه انسان; Hepatocyte characterization methods; Cytochrome P450; HepaRG; Intrinsic clearance; P450 enzyme induction; Primary human hepatocytes
Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner
Keywords: hepatocytes اولیه انسان; Augmenter of liver regeneration; Human hepatocytes; Liver regeneration; AKT/PKB; ERK1/2; Liver specificity; AP-1; activator protein-1; rhALR; recombinant human augmenter of liver regeneration; EGF; epidermal growth factor; ERK1/2; extracellular signal-reg
Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes
Keywords: hepatocytes اولیه انسان; Aryl hydrocarbon receptor; 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Primary human hepatocytes; Target genes; Small-interfering RNAs
Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis
Keywords: hepatocytes اولیه انسان; ACSL5; acyl-CoA synthetase long chain isoform 5; TNFα; Tumor necrosis factor alpha; TRAIL; TNFα related apoptosis inducing ligand; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohepatitis; CMV; cytomegalievirus; CamR; chloramphenico
Monoclonal Anti-Claudin 1 Antibodies Prevent Hepatitis C Virus Infection of Primary Human Hepatocytes
Keywords: hepatocytes اولیه انسان; Antiviral; Genetic Barrier; Host Factor; Receptor; Treatment; CLDN; claudin; CMFDA; 5-chloromethylfluorescein di-acetate; CTRL; control; EL1; extracellular loop 1; HA-tag; hemaglutinin-tag; HCV; hepatitis C virus; HCVcc; cell culture-derived HCV; HCVpp; H
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells
Keywords: hepatocytes اولیه انسان; Toxicogenomics; HepaRG cells; Primary human hepatocytes; Microarrays; Gene expression; Phenobarbital; Venn diagram; Clustering; Principal component analysis; Ingenuity Pathway Analysis
Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes
Keywords: hepatocytes اولیه انسان; Primary human hepatocytes; Lentivirus; Differentiation; CAR; siRNA
Nouvelles perspectives d'utilisation des hépatocytes humains au cours du développement préclinique des médicaments
Keywords: hepatocytes اولیه انسان; Hépatocytes humains primaires; Lignées d'hépatome; Métabolisme des médicaments; Primary human hepatocytes; Hepatoma cell lines; Drug metabolism;
Expression profiling of interindividual variability following xenobiotic exposures in primary human hepatocyte cultures
Keywords: hepatocytes اولیه انسان; DNA microarray; Primary human hepatocytes; Interindividual variability
Interleukin-1β stimulates acute phase response and C-reactive protein synthesis by inducing an NFκB- and C/EBPβ-dependent autocrine interleukin-6 loop
Keywords: hepatocytes اولیه انسان; IL-1β; IL-6; CRP; Primary human hepatocytes