Keywords: T2DM; type 2 diabetes; IR; insulin resistance; HbA1c; glycated hemoglobin A1c; GLUT-4; glucose transporter4; GLP-1; glucagon-like peptide-1; DPP4; dipeptidyl peptidase; eGFR; estimated glomerular filtration rate; HF; heart failure; UKPDS; United Kingdom P
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Keywords: AT; adipose tissue; LPS; lipopolysaccharide; OSA; obstructive sleep apnea; PPARγ; peroxisome proliferator-activated receptor-gamma; PTP-1B; protein tyrosine phosphatase 1B; Obstructive sleep apnea adipose tissue; Insulin resistance; Macrophage; Epigeneti
Keywords: 3-MP; 3-mercaptopyruvate; 3-MST; 3-mercaptopyruvate sulfurtransferase; AAT; aspartate amino transferase; AE1; anion exchanger-1; AGEs; advanced glycation end products; AKI; acute kidney injury; AMPK; AMP-activated protein kinase; AT1; angiotensin receptor
Keywords: Human primary adipocytes; Anthocyanidins; Anthocyanins; Malvidin; Peonidin; Inflammatory gene expression; Lipid Metabolism; ACC; acetyl-CoA carboxylase; aP2; adipocyte fatty acid binding protein; COX; cyclooxygenase; HF; high fat; HSL; hormone sensitive l
In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives
Keywords: RGKMKULXFZOUPF-BQSMYOSZSA-N; SXYLITRDEAEYTJ-MGPMMZCJSA-N; Diabetes; Moronic acid derivatives; PTP-1B; Molecular docking; Enzyme inhibition;
Design, synthesis, in vitro, in vivo and in silico pharmacological characterization of antidiabetic N-Boc-l-tyrosine-based compounds
Keywords: Diabetes; PTP-1B; PPAR; GLUT-4; Polypharmacology; Drug design;
Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation
Keywords: RSV; resveratrol; STZ; streptozotocin; ROS; reactive oxygen species; RNS; reactive nitrogen species; SOD; superoxide dismutase; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; kelch-like ECH-associated protein 1; NQO-1; NAD(P)H:quinone oxidoredu
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
In vitro and in vivo antidiabetic effect of extracts of Melia azedarach, Zanthoxylum alatum, and Tanacetum nubigenum
Keywords: Type-2 diabetes mellitus; C2C12 cultured cell line; STZ induced diabetic rats; PTP-1B;
Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity
Keywords: PPARγ; Phosphorylation; c-Src; PTP-1B; Inflammation; Metabolic disorders;
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues
Keywords: Tyrosine phosphatases inhibitors; Natural 3-acyl-5-hydroxymethyltetronic acid; RK-682; Meldrum's acid derivatives; Enzyme inhibition; Promiscuous enzyme inhibition; PTP-1B; protein tyrosine phosphatase 1B; LMW-PTP; low molecular weight protein tyrosine ph
Cocoa flavonoids attenuate high glucose-induced insulin signalling blockade and modulate glucose uptake and production in human HepG2 cells
Keywords: AKT/PKB; protein kinase B; AMPK; 5â²-AMP-activated protein kinase; BrdU; 5-bromo-2â²-deoxyuridine; CaMMK; Ca2+/calmodulin-dependent protein kinase kinase; CPE; cocoa phenolic extract; EC; (â)-epicatechin; EGCG; epigallocatechin gallate; ERK; extracell
The structural basis of action of vanadyl (VO2+) chelates in cells
Keywords: acac; acetylacetonate, as in bis(acetylacetonato)oxidovanadium(IV) or VO(acac)2; alx; allixin; ASP; acylation-stimulating protein; CHO; Chinese hamster ovary; ENDOR; electron nuclear double resonance; EGFR; epidermal growth factor receptor; EPR; electron
Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice
Keywords: Propiophenone; Antidiabetic; PTP-1B; db/db Mice; Body weight;
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: In vitro, in silico, and in vivo approaches
Keywords: Diabetes; Pentacyclic triterpenoids; PTP-1B; Docking; Enzyme inhibition;
Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat
Keywords: ER; endoplasmic reticulum; UPR; unfolded protein response; IRE1α; inositol-requiring transmembrane kinase/endonuclease; PERK; PKR-like ER kinase; ATF6; activating transcription factor 6; XBP-1; X-Box-binding protein 1; JNK; jun N-terminal kinase; ERK; ex
Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: Roles of Protein Tyrosine Phosphatase-1B
Keywords: Insulin resistance; Angiotensin II; PTP-1B; Growth;
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents
Keywords: Polyhydroquinoline; Antihyperglcemic; Antidyslipidemic; PTP-1B; Glycogen phosphorylase
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives
Keywords: Cyclopenta[d][1,2]-oxazine; PTP-1B; Inhibitor; Diabetes