Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: In vitro, in silico, and in vivo approaches

► Ursolic, oleanolic, moronic and morolic acids induced in vivo antidiabetic action. ► Triterpenic acids provoked PTP-1B inhibition. ► Docking with PTP-1B suggested the potential binding of the triterpenic acids in a binding pocket next to the catalytic site.