VDAC closure increases calcium ion flux
Keywords: PTP; Mitochondria; Apoptosis; Voltage gating; Swelling; Planar membrane
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Assessment of pretest probability of pulmonary embolism in the emergency department by physicians in training using the Wells model
Keywords: ED; emergency department; PE; pulmonary embolism; DVT; deep vein thrombosis; VTE; venous thromboembolism; PTP; pretest probability; V/Q scan; ventilation/perfusion scan; CT; computed tomography; CI; confidence interval.; Pretest probability; Pulmonary emb
Temperature dependence of binding and catalysis for the Cdc25B phosphatase
Keywords: Cdk2-pTpY/CycA; cyclin-dependent kinase 2 complexed with cyclin A and bis-phosphorylated on Thr14 and Tyr15; PTP; protein tyrosine phosphatase; pNPP; p-nitrophenyl phosphate; ES; enzyme-substrate.; Protein-protein interactions; Protein tyrosine phos
Discontinuing Mechanical Ventilatory Support
Keywords: mechanical ventilation; respiratory failure; weaning; ASV; adaptive support ventilation; f; frequency; Fio2; fraction of inspired oxygen; NIV; noninvasive ventilation; PAV; proportional assist ventilation; PEEP; positive end-expiratory pressure; PES; esop
Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1
Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW; low molecular weight; Ltp1; S. cerevisiae LMW-PTP; pNPP; p-nitrophenyl phosphate; GST; glutathione S-transferase; CD; circular dichroism; PTP; LMW-PTP; Ltp1; Tyrosine phosphorylation; Y
Defining SH2 domain and PTP specificity by screening combinatorial peptide libraries
Keywords: SH2 domain; PTP; Combinatorial peptide library; Sequence specificity; Partial edman degradation; Phosphotyrosine; Protein–protein interaction; Signal transduction
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
Chromium and vanadate combination increases insulin-induced glucose uptake by 3T3-L1 adipocytes
Keywords: P-Tyr; MAPK; 4E-BP1; PTP; GLUT4
6-Pyruvoyltetrahydropterin synthase orthologs of either a single or dual domain structure are responsible for tetrahydrobiopterin synthesis in bacteria
Keywords: 6-Pyruvoyltetrahydropterin synthase; Tetrahydrobiopterin; Cyanobacteria; Green sulfur bacteria; Bimodular structure; ParalogBH4, tetrahydrobiopterin; GTPCH, GTP cyclohydrolase I; H2-NTP, dihydroneopterin triphosphate; PPH4, 6-pyruvoyltetrahydropterin; PTP
Mitochondrial metabolism in mammalian cold-acclimation: Magnitude and mechanisms of fatty-acid uncoupling
Keywords: Mitochondria; Uncoupling; Fatty-acid; Cold-acclimation; Rat; Mammal; UCP; ANT; PTP
A novel SOD-mimetic permeability transition inhibitor agent protects ischemic heart by inhibiting both apoptotic and necrotic cell death
Keywords: Î; mitochondrial membrane potential; CsA; cyclosporin A; ROS; reactive oxygen species; mPT; mitochondrial permeability transition; PTP; permeability transition pore; cyt-c; cytochrome c; Cr-P; creatine phosphate; MTT+; 3-(4,5-dimethyl-2-thiazolyl)-2,5-di
Mathematical model of mitochondrial ionic homeostasis: Three modes of Ca2+ transport
Keywords: Mitochondria; PTP; Oscillation; Mathematical model; Ions transport
Protein tyrosine and serine–threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: Identification and potential functions
Keywords: Phosphatase; PTP; DSP; MKP; Serine–threonine phosphatase; PPP; PPM; Genome; Strongylocentrotus; Urchin
Rhodanine derivatives as inhibitors of JSP-1
Keywords: Rhodanine; PTP; DSP
The Tyrosine Phosphatase, SHP-1, Is a Negative Regulator of Endothelial Superoxide Formation
Keywords: AS-ODN; antisense oligodesoxynucleotide; HUVEC; human umbilical vein endothelial cells; NAD(P)H; reduced nicotinamide adenine dinucleotide (phosphate); O2·â; superoxide radical; PI3K; phosphatidyl-inositol-3-kinase; PTP; protein tyrosine phosphatase; A
Pomolic acid triggers mitochondria-dependent apoptotic cell death in leukemia cell line
Keywords: Pomolic acid; Apoptosis; Mitochondria membrane potential; Cancer therapy; Leukemia; MDR; ÎÏm; mitochondrial transmembrane potential; ANT; adenine nucleotide translocator; Apaf-1; apoptotic protease activating factor-1; CD95-L; CD95-ligand; CsA; cyclospo
Effects of Adding Extra Molasses to a Texturized Calf Starter on Rumen Development, Growth Characteristics, and Blood Parameters in Neonatal Dairy Calves*
Keywords: molasses; rumen development; calves; ADG; average daily gain; BVFA; blood VFA; CO; 5% molasses; EM; 12% molasses; FE; feed efficiency; HEM; blood hematocrit; HG; heart girth; HH; hip height; HW; hip width; PTP; plasma total protein; WH; withers height;
Functional studies of protein tyrosine phosphatases with chemical approaches
Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; FAK; focal adhesion kinase; ERK; extracellular signal-regulated kinase; p130Cas; Crk associated substrate.; Protein tyrosine phosphatase; PTP1B; Protein tyrosine phosphatase inhibitor; Chemi
Species-specific modulation of the mitochondrial permeability transition by norbormide
Keywords: ANS; 8-anilino-1-naphthalene sulfonic acid; CsA; cyclosporine A; DPH; 1,6-diphenyl-1,3,5-hexatriene; FCCP; carbonylcyanide-p-trifluoromethoxyphenyl hydrazone; Laurdan; 6-dodecanoyl-2-dimethyl-aminonaphthalene; MOPS; 4-morpholinepropanesulfonic acid; Norbo
Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions
Keywords: apoptosis; mitochondria; Parkinson; neurodegeneration; caspases; ROS; AD; Alzheimer disease; FCCP; carbonyl cyanide 4-trifluoromethoxyphenlhydrazone; GST; glutathione; iNOS; inducible nitric oxide synthase; mBCl; monochlorobimane; MTT; 3-[4,5-dimethylthia
Methods for identifying extracellular ligands of RPTPs
Keywords: Receptor tyrosine phosphatase; Receptor affinity probe; Ligand; RAP assay; Alkaline phosphatase; Ectodomain; Histochemistry; PTP;
Substrate-trapping techniques in the identification of cellular PTP targets
Keywords: Substrate-trapping; PTP; Protein-tyrosine phosphatase; PTP1B; GST pulldown;
Electroacupuncture up-regulates natural killer cell activity
Keywords: Electroacupuncture; NK cell; PTP; PTK; SHP-1; VCAM-1;
Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase
Keywords: RT-PCR; reverse transcribed PCR; MAPK; mitogen-activated protein kinase; PTP; protein tyrosine phosphatase; DSP; protein dual specificity phosphatase; LCPTP; leukocyte-specific protein tyrosine phosphatase; HePTP; hematopoietic tissue-specific protein tyr
The multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide
Keywords: ADP; adenosine diphosphate; CNTF; ciliary neurotrophic factor; CTLD; C-type lectin domains; CTLD-LSNP; C-type lectin-like domain linked to a short N-terminal peptide; GRF; growth hormone-releasing factor; HIP; hepatic intestinal pancreatic protein; HMG-I/
Therapeutic role of coenzyme Q10 in Parkinson's disease
Keywords: AIF; apoptosis-inducing factor; ATP; adenosine 5â² triphosphate; C. elegans; Caenorhabditis elegans; CoA; coenzyme A; ETC; electron transport chain; FADH2; flavin adenine dinucleotide; IAP; inhibitors of apoptosis proteins; MOMP; mitochondrial outer memb
Tyrosine phosphorylation in mitochondria: A new frontier in mitochondrial signaling
Keywords: AKAP; A-kinase anchoring protein; CcO; cytochrome c oxidase; DSP; dual-specificity phosphatase; EGFR; epidermal growth factor receptor; ETC; electron transport chain; Hsp; heat shock protein; MKP-1; MAPK phosphatase 1; PH; Pleckstrin homology; PHGPx; phos
The JAK2V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis
Keywords: AML; acute myeloid leukemia; ATP; adenosine triphosphate; CMD; chronic myeloid disorders; CML; chronic myeloid leukemia; CMML; chronic myelomonocytic leukemia; CNL; chronic neutrophilic leukemia; CPTK; cytoplasmic PTK; EEC; endogenous erythroid colony; Ep
The interaction of flavonoids with mitochondria: effects on energetic processes
Keywords: CCCP; carbonyl cyanide m-chlorophenylhydrazone; CsA; cyclosporin A; EGTA; ethylene glycol bis(-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; HEPES; N-(2-hydroxyethyl) piperazine-Nâ²-(2-ethanesulfonic acid); MPT; mitochondria permeability transition;
Mitochondrial permeability transitions: how many doors to the house?
Keywords: ANT; adenine nucleotide translocator; CATR; Carboxyatractyloside; CK; creatine kinase; CSA; cyclosporin A; CypD; cyclophilin D; GSK-3β; glycogen synthase kinase 3β; HK; hexokinase; MCC; multiple conductance channel; MMC; mitochondrial megachannel; PA2;
Fat intake reverses the beneficial effects of low caloric intake on skeletal muscle mitochondrial H2O2 production
Keywords: ROS; reactive oxygen species; HC; high carbohydrate; HF; high fat; ETC; electron transport chain; PTP; permeability transition pore; EE; energy expenditure; TEE; total EE; EEdark; EE during the dark phase; BSA; bovine serum albumin; BCA; bicinchoninic aci
β-Carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway
Keywords: Apoptosis; Mitochondrion; Caspases; β-Carbolines; Cerebellar granule neurons; βC; β-carboline; βCCB; β-carboline-3-carboxylic acid ester; ÎΨm; mitochondrial membrane potential; AIF; apoptosis-inducing factor; BA; bongkrekic acid; CGN; cerebellar gr
The aldehyde acrolein induces apoptosis via activation of the mitochondrial pathway
Keywords: AFC; amino trifluorocoumarin; AMC; amino methylcoumarin; BSA; bovine serum albumin; BSAO; bovine serum amine oxidase; CAD; caspase activated DNase; CHAPS; 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonic acid; CHO; Chinese hamster ovary;
Protein kinase structure and function analysis with chemical tools
Keywords: AANAT; serotonin N-acetyltransferase or arylalkylamine N-acetyltransferase; aPP; avian pancreatic polypeptide; CaMKII; Ca2+/calmodulin kinase II; CAT; chloramphenicol acetyltransferase; CHO; Chinese hamster ovary; Csk; C-terminal Src kinase; Fmoc; fluoren
Right time, right place: the organization of membrane proximal signaling
Keywords: AP-1; activator protein 1; Bam32; B-lymphocyte adaptor molecule of 32Â kDa; BCR; B-cell receptor; Cbp; Csk binding protein; Csk; carboxyl-terminal Src kinase; DAG; diacylglycerol; DAPP1; dual adaptor for phosphotyrosine and 3-phosphoinositides; ERK; extra
Reactive oxygen species and Udx1 during early sea urchin development
Keywords: DPI; diphenyleneiodonium; duox; dual oxidase; H2O2; hydrogen peroxide; H2DCFDA; 5-(and-6)-carboxy-2â²,7â²-dichlorodihydrofluorescein diacetate; IP3; inositol 1,4,5-trisphosphate; IPD; imaging photon detector; MAPK; mitogen-activated protein kinase; PTP;
In vitro formation and activity-dependent plasticity of synapses between Helix neurons involved in the neural control of feeding and withdrawal behaviors
Keywords: mollusk; soma-soma cell culture; synaptogenesis; gap junctions; protein tyrosine kinases; short-term homosynaptic plasticity; ANOVA; analysis of variance; BSA; bovine serum albumin; CM; conditioned medium; DM; chemically defined medium; DMSO; dimethyl s
Thirty years of olfactory learning and memory research in Drosophila melanogaster
Keywords: STM; short term memory; MTM; middle term memory; LTM; long term memory; ARM; anesthesia resistant memory; ASM; anesthesia sensitive memory; CS; conditioned stimulus; US; unconditioned stimulus; EMS; ethyl methane sulfonate; mbd; mushroom body deranged; mb
Plasticity of synaptic transmission in autonomic ganglia
Keywords: ACh; acetylcholine; ACTH; adrenocorticotropic hormone; CaMKII; calcium calmodulin kinase II; CAP; compound action potential; cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; CO; carbon monoxide; CNS; central nervous system; EPSC