Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses
Keywords: NMDA receptor; Ephrin-B3; EphB2 RTK; Hippocampus; CA1; Excitatory synapse; In cis signaling; Pyk2;
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Research ReportChemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway
Keywords: CKLF1; chemokine-like factor 1; PYK2; proline-rich tyrosine kinase 2; F-actin; filamentous actin; CCR4; chemokine (C-C motif) receptor 4; PYK2-DN; PYK2-dominant-negative; Rac1; Ras-related C3 botulinum toxin substrate 1; Rac1-DN; Rac1-dominant-negative; P
Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis
Keywords: SILAC; stable isotope labeling of amino acids in cell culture; Mifepristone; 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one; ICC; immunocytochemistry; MS; mass spectrometry; PYK2; Phosphoproteomics; Osteogenesis; hMSCs; Me
Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells
Keywords: Pyk2; Kinase; Small molecule; Chemical screen; Molecular model; Osteoblast; Bone
FAK mediates the inhibition of glioma cell migration by truncated 24 kDa FGF-2
Keywords: Malignant glioma; FAK; Phosphorylation; Pyk2
Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity
Keywords: PYK2; FAK; Kinase; Osteoporosis; hERG; Sulfoximine
The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration
Keywords: Osteoclast; Podosome; Wrch1; Pyk2; Integrin
FAK nuclear export signal sequences
Keywords: FAK; Nuclear export signal; Pyk2
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation
Keywords: PYK2; FAK; Kinase; Osteoporosis; Bioactivation; Reactive metabolite
Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer
Keywords: PYK2; Expression and activation; NSCLC; Metastasis; ERK1/2
Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPβ is involved in PMA-induced monocyte differentiation
Keywords: Pyk2; proline-rich tyrosine kinase2; FAK; focal adhesion kinase; PMA; phorbol 12-mystate 13-acetate; C/EBPβ; CCAAT enhancer-binding protein β; FN; fibronectin; MEK/ERK; MAPK/ERK kinase/extracellular signal-regulated kinases; NBT; nitroblue tetrazolium;
CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling
Keywords: Signal transduction; Heart failure; PYK2; Gene therapy; Focal adhesion kinase; Optison; Ultrasound;
Interferon gamma-dependent transactivation of epidermal growth factor receptor
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; IFNγ; interferon gamma; IFNγR; interferon gamma receptor; JAK; Janus kinase; STAT; signal transducer and activator of transcription; TGF-α; transforming growth factor-α; HB-EGF; hep
The acid-activated signaling pathway: Starting with Pyk2 and ending with increased NHE3 activity
Keywords: NHE3; cell pH; endothelin B receptor; Rho kinase; Pyk2; pH sensor
α2β1 and αVβ1 integrin signaling pathways mediate amyloid-β-induced neurotoxicity
Keywords: Amyloid-β; Alzheimer's disease; α2β1 and αVβ1 integrin; Pyk2; Neurodegeneration
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion
Keywords: cerebral ischemia; GABA receptor; NMDA receptor; muscimol; baclofen; Src; CAMK II; CaM-dependent protein kinase II; DAPI; 4â²,6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; EBSS; Earl's balanced salt solution; h-DMEM; high-glucos
Phospholipase C-γ1 potentiates integrin-dependent cell spreading and migration through Pyk2/paxillin activation
Keywords: Phospholipase C-γ1; Pyk2; Paxillin; Rac1; Integrin; Adhesion; Migration
Reconciling the roles of FAK in osteoblast differentiation, osteoclast remodeling, and bone regeneration
Keywords: Osteoblasts; Focal adhesion kinase (FAK); Skeletal regeneration; Osteoclasts; Pyk2
Calcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activities
Keywords: Calcitonin; Osteoclast; Podosome; Src; Pyk2
Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus
Keywords: NMDA; Pilocarpine; Status epilepticus; Phosphorylation; Src; Pyk2;
Expression and intracellular localization of Pyk2 in normal and v-src transformed chicken epiphyseal chondrocytes
Keywords: Pyk2; chondrocytes; v-src; mitochondrial and nuclear Pyk2 localization; CEC; chicken epiphyseal chondrocytes; CECtsLA29 36°; infected CEC expressing active v-Src kinase; CECtsLA29 41°; infected CEC expressing an inactive v-Src kinase; FAK; focal adhesio
Cyclic strain promotes shuttling of PYK2/Hic-5 complex from focal contacts in osteoblast-like cells
Keywords: PYK2; FAK; Hic-5; Paxillin; Focal contact; Osteoblasts; Cyclic strain;
Critical role of the FERM domain in Pyk2 stimulated glioma cell migration
Keywords: Glioma; Pyk2; Focal adhesion kinase; Migration; Tyrosine kinase; Invasion
Prion protein induced signaling cascades in monocytes
Keywords: Prion protein; Prion signaling; Prion function; Monocytes; Syk; Pyk2; Cbl; Fyn; MAPK; Akt
G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: A possible mechanism for exacerbation of multiple sclerosis
Keywords: Multiple sclerosis; G-CSF; Autoreactive T cell lines; Extracellular matrix; Pyk2; β1-integrins
Suppression of Pyk2 attenuated the increased tyrosine phosphorylation of NMDA receptor subunit 2A after brain ischemia in rat hippocampus
Keywords: Brain ischemia; NMDA receptor; Pyk2; Tyrosine phosphorylation; Src;
Role of PYK2 in the development of obesity and insulin resistance
Keywords: PYK2; Knockout; Obesity;
Tumor Necrosis Factor-α Mediates Pancreatitis Responses in Acinar Cells via Protein Kinase C and Proline-Rich Tyrosine Kinase 2
Keywords: EMSA; electrophoretic mobility shift assay; NF-κB; nuclear factor-κB; PKC; protein kinase C; PLC; phospholipase; Pyk2; proline-rich tyrosine kinase 2; TNF; tumor necrosis factor;