Keywords: Chondrocyte; Cartilage; Osteoarthritis; Bone morphogenetic proteins; Matrix metalloproteinases; AC; articular cartilage; Ad.; adenoviral; ADSCs; adipose-derived stem cells; BMP; bone morphogenetic protein; BAMBI; BMP and Activin membrane combined inhibito
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Keywords: AA; aortic aneurysm; TAA; thoracic aortic aneurysms; AAA; abdominal aortic aneurysm; TAAD; thoracic aortic aneurysms and dissections; FBN1; Fibrillin 1; MFAP5; Microfibril associated protein 5; SMC; smooth muscle cell; MFS; Marfan syndrome; MYH11; myosin
Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
Keywords: ACE2; angiotensin-converting enzyme-2; AGE; advanced glycation end-product; AT1R; angiotensin type 1 receptor; BMP; bone morphogenetic proteins; BMP-7; bone morphogenetic protein 7; CKD; chronic kidney diseases; Co-Smads; common mediator Smads; ECM; extra
Astaxanthin: A mechanistic review on its biological activities and health benefits
Keywords: Astaxanthin (PubChem CID: 5368397); Beta-Carotene (PubChem CID: 5280489); Beta-Cryptoxanthin (PubChem CID: 5281235); Canthaxanthin (PubChem CID: 5281227); Lutein (PubChem CID: 5281243); Zeaxanthin (PubChem CID: 5280899); Alpha-Tocopherol (PubChem CID: 149
Functional characteristics of a novel SMAD4 mutation from thoracic aortic aneurysms (TAA)
Keywords: AA; aortic aneurysm; TAA; thoracic aortic aneurysms; TGF-β; transforming growth factor β; R-Smads; receptor-regulated Smads; FBN1; fibrillin-1; TGFBR1; TGF-β receptor 1; TGFBR2; TGF-β receptor 2; TGFB2; transforming growth factor beta 2; TGFB3; transf
MicroRNA-181a and its target Smad 7 as potential biomarkers for tracking child acute lymphoblastic leukemia
Keywords: ALL; Acute lymphoblastic leukemia; AML; acute myeloid leukemia; CDKs; cyclin-dependent kinases; CLL; chronic lymphocytic leukemia; ELISA; enzyme linked immunosorbent assay; GSK3β; glycogen synthase kinase 3β; I-Smads; inhibitory Smads; qRT-PCR; quantita
Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators
Keywords: BMP; bone morphogenetic protein; Cldn1; Claudin1; Co-Smad; common-partner Smad; CRC; colorectal cancer; DSS; dextran sodium sulfate; ECM; extracellular matrix; EMT; epithelial to mesenchymal transition; GALT; gut-associated lymphoid tissue; Id; inhibitor
Astaxanthin attenuated pressure overload-induced cardiac dysfunction and myocardial fibrosis: Partially by activating SIRT1
Keywords: AST; Astaxanthin; BNP; brain natriuretic peptide; BW; body weight; EX-527; a selective SIRT1 inhibitor, 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; EF%; percentage ejection fraction; FS%; percentage fractional shortening; HCFs; human cardiac f
A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity
Keywords: TGF-β; transforming growth factor beta; R-Smads; receptor Smads; Ub; ubiquitin; RING; really interesting new gene; HSQC; heteronuclear single quantum coherence; APSY; automated projection spectroscopy; NOE; nuclear Overhauser effect; WT; wild-type; CSP;
TGF-β superfamily signaling in testis formation and early male germline development
Keywords: ALK; activin receptor-like kinase; BMPs; bone morphogenetic proteins; Co-Smads; common-mediator Smads; FGF; fibroblast growth factor; GDFs; growth differentiation factors; I-Smads; inhibitory Smads; PGCs; primordial germ cells; R-Smads; receptor-regulated
ANRIL inhibits p15INK4b through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma
Keywords: ANRIL; antisense non-coding RNA in the INK4 locus; ESCC; esophageal squamous cell carcinoma; qPCR; quantitative real-time polymerase chain reaction; TGFβ1; transforming growth factor β1; lncRNAs; long non-coding RNAs; TβRII; TGFβ type II receptor; Tβ
TGF-β-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells
Keywords: TGF-β; transforming growth factor-β; IGF; insulin-like growth factor; IGFBP-3; IGF binding protein-3; TβR; TGF-β receptor; IGF1R; type I IGF receptor; TβRII; TGF-β type II receptor; TβRI; TGF-β type I receptor; R-Smads; receptor-activated Smads; M
Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells
Keywords: BMPs; bone morphogenetic proteins; TGF-β; transforming growth factor-β; I-Smad; inhibitory Smad; HSCs; hematopoietic stem cells; BMPRI; BMP type I receptor; R-Smads; receptor-regulated Smads; KLF1/EKLF; Kruppel-like factor 1 (erythroid); GATA; GATA bind
Using mice to unveil the genetics of cancer resistance
Keywords: AC; adenocarcinoma; AOM; azoxymethane; APC; antigen-presenting cells; BH; BCL2 homology; CCl4; carbon tetrachloride; cM; centimorgan; COX; cyclo-oxygenase; CTLA-4; cytotoxic T-lymphocyte antigen 4; DC; dendritic cells; DEN; diethylnitrosamine; DMBA; 7,12-
Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model
Keywords: ATF; activating transcriptional factor; DEHP; di(2-ethylhexyl) phthalate; DEN; N-diethylnitrosamine; early-stage; 6Â weeks after starting tumor promotion; FB; fenbendazole; GST-P; glutathione S-transferase placental form; late-stage; 57Â weeks after start
Smads and chromatin modulation
Keywords: AER; apical ectodermal ridge; ACF; ATP-utilizing chromatin assembly and remodeling factor; AML; acute myeloid leukaemia; AMT; arginine methyl transferase; ARC; activator-recruited cofactor; BAF; BRG1/hBRM-associated factors; BMP; bone morphogenic protein;