کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8451799 | 1547698 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators
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کلمات کلیدی
ECMDextran sodium sulfate (DSS)RunxR-SmadsBone Morphogenetic Proteins (BMP)co-SMADMLNSMADCLDN1uPATGF-βDSSI-SmadsGALTInhibitory Smads - اسم مهارکنندهSmurf - اسمورفepithelial to mesenchymal transition - اپیتلیال به انتقال مزانشیمالImmunohistochemistry - ایمونوهیستوشیمیIHC - ایمونوهیستوشیمیgut-associated lymphoid tissue - باکتری لنفوئیدی مرتبط با رودهtransforming growth factor-β - تبدیل فاکتور رشد βEMT - تکنسین فوریتهای پزشکیColorectal cancer - سرطان روده بزرگColorectal cancer (CRC) - سرطان کولورکتال (CRC)dextran sodium sulfate - سولفات سدیم سدیمreceptor-regulated Smads - سیگنال های گیرنده تنظیم شدهurokinase-type plasminogen activator - فعال کننده پلاسمینوژن نوع urokinaseExtracellular matrix - ماتریکس خارج سلولیMouse model - مدل موشBMP - مدیریت فرایند کسب و کارinhibitor of differentiation - مهار کننده تمایزBone morphogenetic protein - پروتئین مورفوژنیک استخوانCRC - کد افزونگی دورهای mesenteric lymph nodes - گره های لنفاوی مزانتریک
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators](/preview/png/8451799.png)
چکیده انگلیسی
Deregulation of the bone morphogenetic protein (BMP) pathway has been documented in colorectal cancer (CRC). Previously, we investigated possible associations between urokinase-type plasminogen activator (uPA) deficiency and expression of extracellular constituents of BMP signaling in a newly developed mouse model of inflammation-driven intestinal neoplasmatogenesis, in which chronic colitis and CRC are induced using dextran sodium sulfate (DSS). In this report, we explored the contribution of intracellular components of Smad-mediated BMP signal transduction using the same model. Interestingly, upon DSS treatment, we noticed an overexpression of Runx1/2/3 transcription factors in both wild-type and uPA-deficient mice. Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals. In all experimental conditions, in situ investigation of Runx-expressing cell types, revealed detection of all three Runx in the immune cells, yet in the DSS-treated/uPA-deficient mice Runx1 and Runx2 were also identified in the preneoplastic epithelium of advanced high-grade dysplasia and carcinoma in-situ colonic lesions. Finally, the uPA-deficient pro-tumorigenic colitic microenvironment exhibited increased levels of the Runx-induced target genes Snai2, Bim and Claudin1, known to have a role in tumor development and progression. These findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 361, Issue 2, 15 December 2017, Pages 257-264
Journal: Experimental Cell Research - Volume 361, Issue 2, 15 December 2017, Pages 257-264
نویسندگان
Hara Afaloniati, George S. Karagiannis, Alexandros Hardas, Theofilos Poutahidis, Katerina Angelopoulou,