Keywords: Neuroendocrine Carcinoma; Neuroendocrine tumors; Cancer; Molecular; p53; Microsatellite Instability; APC; Adenomatous Polyposis Coli gene; ATM; Ataxia telangiectasia mutated gene; ATRX; Alpha-thalassemia mental retardation syndrome gene; CASP8; Caspase-8
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Keywords: Melanoma; Liquid biopsy; Circulating tumor cells; Cell-free circulating tumor DNA; Cell-free DNA; Cell-free microRNA; Ab; antibody; AIM1; absent in melanoma-1; AJCC; American Joint Committee on Cancer; BRAF; B-Raf proto-oncogene, serine/threonine kinase;
Keywords: CCA; cholangiocarcinoma; OS; overall survival; miRNA; microRNA; TSG; tumor suppressor genes; ICC; intrahepatic cholangiocarcinoma; OV; Opisthorchis viverrini; CpG; scytosine guanine dinucleotides; DNMT; DNA methyltransferases; EZH2; zeste homolog 2; RASSF
Keywords: α-TOS; α-tocopheryl succinate; BAP1; BRCA1 associated protein-1; BRCA1; breast cancer susceptibility gene 1; CDK4; cyclin-dependent kinase 4; CEA; carcinoembryonic antigen; CSC(s); cancer stem(-like) cell(s); CTGF; connective tissue growth factor (CCN2)
Keywords: Epigenetics; Phytochemicals; DNA-methylation; Histone-modification; miRNA; Carcinogenesis; Akt; v-akt murine thymoma viral oncogene homolog 1; AP-1; Activator Protein-1; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; Bcl-xL; B-cell lymphoma-
Diagnostic value of RASSF1A hypermethylation in colorectal cancer: a meta-analysis
Keywords: CRC; colorectal cancer; RASSF1A; ras association domain family 1 isoform A; CNKI; Chinese National Knowledge Infrastructure; SROC; summary receiver operating characteristics; AUC; area under the curve; RASSF; ras association domain family; ORs; odds ratio
DNA methylation: A critical epigenetic mechanism underlying the detrimental effects of airborne particulate matter
Keywords: 5-mC; 5-methylcytosine; ACE; Angiotensin I converting enzyme; APEX; Apurinic/apyrimidinic endodeoxyribonuclease; BC; black carbon; CD40LG; CD40 ligand; EDN1; Endothelin 1; F3; coagulation factor III; Foxp3; Forkhead box protein 3; ICAM-1; Intercellular ad
In utero and lactational exposure of DEHP increases the susceptibility of prostate carcinogenesis in male offspring through PSCA hypomethylation
Keywords: DEHP; di(2-ethylhexyl) phthalate; PCa; prostate cancer; IUL; in utero and lactational; ESR2; estrogen receptor 2; GSTP1; glutathione S-transferase pi 1; NKX3.1; NK3 homeobox 1; PSCA; prostate stem cell antigen; PTGS2; prostaglandin-endoperoxide synthase 2
RACK1/TRAF2 regulation of modulator of apoptosis-1 (MOAP-1)
Keywords: MOAP-1; Ubiquitination; Apoptosis; TRAF2; RACK1; RASSF1A; PKC;
Original ContributionMethylation analysis of SHOX2 and RASSF1A in bronchoalveolar lavage fluid for early lung cancer diagnosis
Keywords: SHOX2; RASSF1A; Methylation; Lung Cancer; Diagnosis;
Potential of RASSF1A promoter methylation as biomarker for endometrial cancer: A systematic review and meta-analysis
Keywords: Ras association domain family 1 isoform A; RASSF1A; Methylation; Meta-analysis; Endometrial cancer;
Frequent silencing of RASSF1A by DNA methylation in thymic neuroendocrine tumours
Keywords: RASSF1A; Thymic neuroendocrine tumour; DNA methylation;
Diagnostic Capacity of RASSF1A Promoter Methylation as a Biomarker in Tissue, Brushing, and Blood Samples of Nasopharyngeal Carcinoma
Keywords: RASSF1A; RAS association domain family protein 1A; NPC; nasopharyngeal carcinoma; OR; odds ratio; 95% CI; 95% confidence interval; AUC; the summary receiver operator characteristic (SROC) curve; TSG; tumor suppressor gene; RASSF1A; Methylation; NPC; Progn
ReviewRas signaling through RASSF proteins
Keywords: Ras; RASSF1A; NORE1A; Apoptosis; Signaling; p53;
Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells
Keywords: PEITC; phenethyl isothiocyanate; RASSF1A; RAS superfamily protein isoform 1A; DNMT; DNA methyl transferases; HDAC; histone deacetylases; MSP; methylation specific PCR; BGS; bisulfite genomic sequencing; PCa; prostate cancer; RASSF1A; Epigenetics; Demethyl
Prognostic role of APC and RASSF1A promoter methylation status in cell free circulating DNA of operable gastric cancer patients
Keywords: MSP, methylation specific PCR; OS, overall survival; PS, performance statusAPC; RASSF1A; DNA methylation; Cell free DNA; Gastric cancer; Prognosis
Identification of protein arginine N-methyltransferase 5 (PRMT5) as a novel interacting protein with the tumor suppressor protein RASSF1A
Keywords: RASSF1A; Tumor suppressor gene; Protein arginine N-methyltransferase 5 (PRMT5); Microtubule; TAP; tandem affinity purification; PRMT; protein arginine N-methyltransferase;
Hypermethylation in gastric cancer
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge
CXCL12 and ADAM23 hypermethylation are associated with advanced breast cancers
Keywords: ADAM23; disintegrin and metalloprotease domain 23; APC; adenomatous polyposis coli; BC; breast cancer; BRMS1; breast cancer metastasis suppressor 1; CDH1; cadherin 1, type 1; cfDNA; cell-free DNA; CMI; cumulative methylation index; CXCL12; chemokine C-X-C
Concomitant PIK3CA amplification and RASSF1A or PAX6 hypermethylation predict worse survival in gastric cancer
Keywords: Q-MSP; quantitative methylation-specific PCR; PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; RASSF1A; Ras association domain family 1 isoform A; PAX6; paired box 6; SDS; sodium dodecyl sulfate; H&E; hematoxylin and eosin;
Hepatitis Virus Infection Affects DNA Methylation in Mice With Humanized Livers
Keywords: Epigenetic; Inflammatory Response; Liver Cancer; Gene Regulation; ESR1; estrogen receptor 1; HBV; hepatitis B virus; HBx; hepatitis B virus X; HCC; hepatocellular carcinoma; HCV; hepatitis C virus; HOXA6; homeobox A6; IFN; interferon; MCAM; methylated CpG
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis
Keywords: APC/C; Anaphase Promoting Complex/Cyclosome; AOM; azoxymethane; Bub3; budding uninhibited by benzimidazole protein 3; BubR1; bub1-related protein; Cdc20; cell division cycle 20; Cdh1; Cdc20 homologue protein 1; DMBA; 7,12-dimethylbenz-α-anthracene; Emi1;
Quantitative analysis of RASSF1A promoter methylation in hepatocellular carcinoma and its prognostic implications
Keywords: DNA methylation; Methylight; HCC; Prognostic biomarker; RASSF1A;
Unexpected close surgical margin in resected buccal cancer: Very close margin and DAPK promoter hypermethylation predict poor clinical outcomes
Keywords: Buccal cancer; Close margin; Methylation; Radiotherapy; DAPK; RASSF1A
Ras Association Domain Family 1A: A Promising Prognostic Marker in Recurrent Nonmuscle Invasive Bladder Cancer
Keywords: Bladder cancer; Methylation; Prognosis; RASSF1A
Regulators of mammalian Hippo pathway in cancer
Keywords: BMP; bone morphogenetic protein; HCC; hepatocellular carcinoma; LATS1/2; large tumor suppressor 1/2; MST1/2; mammalian sterile 20-like kinase 1/2; RASSF1A; Ras-association domain family 1 isoform A; SAV1; Salvador; TGF-β; transforming growth factor-beta;
DNA methylation-based biomarkers in serum of patients with breast cancer
Keywords: 5-Aza-CdR; 5-aza-2â²-deoxycytidine; 5-Aza-CR; 5-azacytidine; 5mC; 5-methylcytidine; AIMS; amplification of inter-methylated sites; APC; adenomatous polyposis coli; BiMP; bisulfite methylation profiling; BRCA1; breast cancer gene 1; BsPP; bisulfite padloc
RASSF1A suppresses the activated K-Ras-induced oxidative DNA damage
Keywords: K-Ras; RASSF1A; ROS; DNA damage
Local signals with global impacts and clinical implications: Lessons from the plasma membrane calcium pump (PMCA4)
Keywords: PMCA; plasma membrane calcium/calmodulin dependent ATPase; SERCA; sarco/endoplasmic reticulum calcium ATPase; SPCA; secretory pathway calcium ATPase; PDZ; PSD 95, Drosophila Discs large protein and Zona occludens-1; MAGUK; membrane-associated guanylate ki
Hypermethylation-modulated Downregulation of RASSF1A Expression Is Associated with the Progression of Esophageal Cancer
Keywords: Esophageal squamous cell carcinoma; RASSF1A; CpG islands; Methylation; Tumor suppressor genes; Prognosis
Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer
Keywords: DNA methylation; Ovarian cancer; RASSF1A; Real time PCR; Serum
Increase sensitivity in detecting superficial, low grade bladder cancer by combination analysis of hypermethylation of E-cadherin, p16, p14, RASSF1A genes in urine
Keywords: Bladder cancer; E-cadherin; Methylation; p14; RASSF1A; Urine
Genetic and Epigenetic Analysis of erbB Signaling Pathway Genes in Lung Cancer
Keywords: EGFR mutation; DNA methylation/epigenetics; RASSF1A; non-small cell lung cancer
Protein kinase A-mediated phosphorylation of the RASSF1A tumour suppressor at Serine 203 and regulation of RASSF1A function
Keywords: RASSF1A; Tumour suppressor; PKA; Phosphorylation; Apoptosis;
DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components
Keywords: Methylation; BAC; p16; RASSF1A; CDH13; RARβ; Cyclin D2;
Prognostic significance of RASSF1A promoter methylation in operable breast cancer
Keywords: RASSF1A; DNA methylation; Operable breast cancer; Epigenetic markers; Prognostic biomarker; Methylation Specific PCR
SKP2 and CKS1 Promote Degradation of Cell Cycle Regulators and Are Associated With Hepatocellular Carcinoma Prognosis
Keywords: APC/C; anaphase-promoting complex; CDH1; cyclosome with cell division cycle 20 related 1; CDK; cyclin-dependent kinase; CKS1; CDC28 protein kinase b1; CDC14B; cell division cycle 14; FOXM1; forkhead box M1B; FOXO1; forkhead box O1; HCC; hepatocellular car
Clinical significance of promoter hypermethylation of RASSF1A, RARβ2, BRCA1 and HOXA5 in breast cancers of Indian patients
Keywords: Promoter hypermethylation; RASSF1A; RARβ2; BRCA1; HOXA5; Breast cancer
Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma
Keywords: retinoblastoma; BRAF mutations; RASSF1A; epigenetic silencing; tumor suppressor genes; methylation status; CIMP; CpG island methylator phenotype
Putative association of the single nucleotide polymorphisms in RASSF1A promoter with Korean lung cancer
Keywords: Lung cancer; RASSF1A; Single nucleotide polymorphism (SNP); Haplotype; Transcriptional activity
Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma
Keywords: Cervical adenocarcinoma; RASSF1A; KRAS; BRAF
Identification of epigenetic aberrant promoter methylation of RASSF1A in serum DNA and its clinicopathological significance in lung cancer
Keywords: DNA methylation; RASSF1A; Tumor suppressor gene; Lung cancer
Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells
Keywords: Mahanine; Carbazole alkaloid; Prostate cancer; RASSF1A; Cyclin D1; Epigenetic silencing
Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias
Keywords: Cervical cancer; HPV; BLU; RASSF1A; Methylation;
Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
Keywords: RASSF1A; Esophageal cancer; Nasopharyngeal carcinoma; Tissue microarray
Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
Keywords: Hypermethylation; Non-small cell lung cancer; Prognosis; RASSF1A; RUNX3; Histological difference
Prognostic significance of RASSF1A promoter methylation on survival of non-small cell lung cancer patients treated with gemcitabine
Keywords: Hypermethylation; NSCLC; RASSF1A; Gemcitabine; Prognosis
Reduced expressions of Foxp1 and Rassf1a genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats
Keywords: Foxp1; Rassf1a; Lung adenocarcinoma; Rat; NitrosamineBHP, N-nitrosobis(2-hydroxypropyl)amine; TSG, tumor suppressor gene; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer
NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma
Keywords: NORE1B; RASSF1A; Epigenetic gene silencing; Human hepatocellular carcinomaCL, cirrhotic liver; DN, dysplastic nodule; FNH, focal nodular hyperplasia; HCA, hepatocellular adenoma; HCC, hepatocellular carcinoma; MSP, methylation sensitive PCR; RASSF, ras as
Molecular prognostic factors in resectable non-small cell lung cancer
Keywords: EGFR; epidermal growth factor receptor; TGF; transforming growth factor; VEGF; vascular endothelial growth factor; HGF; hepatocyte growth factor; MMP; matrix metalloproteinases; DAPK; death-associated protein kinase; RASSF1A; ras association domain family