کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116732 1085027 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Reduced expression of RASSF1A in esophageal and nasopharyngeal carcinomas significantly correlates with tumor stage
چکیده انگلیسی

Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 257, Issue 2, 18 November 2007, Pages 199–205
نویسندگان
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