Keywords: حلقه مرکز واکنش; A2Ms; α-2- macroglobulins; AFLEI; elastase inhibitor from Aspergillus flavus; AFUEI; elastase inhibitor from Aspergillus fumigatus; AP; α-2-antiplasmin; AT; antithrombin; bFGF; basic fibroblast growth factor; BSuPI; Bacillus subtilis protease inhibitor;
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Keywords: حلقه مرکز واکنش; AtSerpin1; Arabidopsis thaliana serpin 1; BSA; bovine serum albumin; Bt; Bacillus thuringiensis; IMAC; immobilized metal-affinity chromatography; LR serpin; serpin with leucine and arginine at positions P2 and P1 of the reactive center loop; RCL; reactive
Keywords: حلقه مرکز واکنش; corticosteroid-binding globulin; free cortisol; reactive center loop; mutation; Coolens equation; sepsisCBG, corticosteroid-binding globulin; IL-6, Interleukin-6; PCOS, polycystic ovary syndrome; R-form, relaxed form; RCL, reactive center loop; S-form, st
Keywords: حلقه مرکز واکنش; AT; Antithrombin; serpin; Serine protease inhibitor; FXa; Factor Xa; RCL; Reactive center loop; Arg; Arginine; Lys; Lysine; VTE; Venous thromboembolism; type II RS; Type II reactive site defects; type II HBS; Type II heparin binding site defects; type II
Manduca sexta serpin-12 controls the prophenoloxidase activation system in larval hemolymph
Keywords: حلقه مرکز واکنش; Insect immunity; Hemolymph protein; Serine protease cascade; Melanization; PO and proPO; phenoloxidase and its precursor; PAP; proPO-activating protease; PG; peptidoglycan; HP; hemolymph protease; CLIP; clip-domain serine protease (SP) or serine protease
Serpin-9 and -13 regulate hemolymph proteases during immune responses of Manduca sexta
Keywords: حلقه مرکز واکنش; Protease inhibitor; Insect immunity; Phenoloxidase; Serine protease cascade; Hemolymph proteins; Reactive center loop; AS; ammonium sulfate; CF, IF, CH, and IH; fat body (F) and hemocytes (H) from control (C, i.e. naïve) and immune challenged (I) larvae;
C1-inhibitor polymers activate the FXII-dependent kallikrein-kinin system: Implication for a role in hereditary angioedema
Keywords: حلقه مرکز واکنش; BSA; bovine serum albumin; C1-inh; complement C1 esterase inhibitor; C1PIV; in vivo sized C1-inh polymers; CPDA; citrate phosphate dextrose adenine; CPK; chromozyme PK; FXII; coagulation factor XII; FXIIa; activated FXII; dBSA; heat denatured BSA; HAE; he
Transcriptomic insight into the immune defenses in the ghost moth, Hepialus xiaojinensis, during an Ophiocordyceps sinensis fungal infection
Keywords: حلقه مرکز واکنش; Hepialus xiaojinensis; Ophiocordyceps sinensis; Transcriptome; Insect immunity; Phylogenetic analysis; Expression profiling; Fat body; AMP; antimicrobial peptide; cSP; clip domain serine protease; CTL; C-type lectin; DEG; Differentially expressed gene; FP
Characterization of the protein Z-dependent protease inhibitor interactive-sites of protein Z
Keywords: حلقه مرکز واکنش; PZ; protein Z; ZPI; protein Z-dependent protease inhibitor; RCL; reactive center loop; ZPI-Y387A; a ZPI mutant in which Tyr-387 has been replaced with an Ala; FXa; activated factor X; Gla; γ-carboxyglutamic acid; EGF; epidermal growth factor; PZ/FX-LC; a
Single amino acid substitutions in recombinant plant-derived human α1-proteinase inhibitor confer enhanced stability and functional efficacy
Keywords: حلقه مرکز واکنش; α1-PI; α1-proteinase inhibitor; CD; circular dichroism; Cm; mid-point of transition; DAC-ELISA; direct antigen coating-enzyme linked immunosorbent assay; PPE; porcine pancreatic elastase; RCL; reactive center loop; TSP; total soluble protein; TUG; trans
Nuclear α1-Antichymotrypsin Promotes Chromatin Condensation and Inhibits Proliferation of Human Hepatocellular Carcinoma Cells
Keywords: حلقه مرکز واکنش; Liver Cancer; Nuclear Factor; Mouse Model; DNA Binding; AAV; adeno-associated virus; α1-ACT; antichymotrypsin; APP; acute-phase protein; APR; acute-phase response; DOX; doxycycline; EGF; epidermal growth factor; HCC; hepatocellular carcinoma; MENT; myelo
Identification of plasma proteinase complexes with serpin-3 in Manduca sexta
Keywords: حلقه مرکز واکنش; Serpin; Hemolymph; Immunity; Hemolymph proteinases; Proteomics; HP; hemolymph proteinase; PAP; prophenoloxidase-activating proteinase; proPO; prophenoloxidase; SPH; serine proteinase homolog; MALDI-TOF/TOF; matrix-assisted laser desorption ionization-time
Effects of glycosylation on the stability and flexibility of a metastable protein: The human serpin α1-antitrypsin
Keywords: حلقه مرکز واکنش; α1-AT; α1-antitrypsin; HPα1-AT; human plasma α1-antitrypsin; RCα1-AT; recombinant α1-antitrypsin; RCL; reactive center loop; GuHCl; guanidine hydrochloride; HXMS; hydrogen/deuterium exchange mass spectrometry; Serpin; Antitrypsin; Glycosylation; Hyd
SERPING1 mutations in 59 families with hereditary angioedema
Keywords: حلقه مرکز واکنش; C1Inh; C1 inhibitor protein; C1NH; C1 inhibitor locus; HAE; hereditary angioedema; RCL; reactive center loop; Hereditary angioedema; C1 Inhibitor; Complement; Rare diseases; Mutational spectrum;
Effect of mutations of the human serpin protein corticosteroid-binding globulin on cortisol-binding, thermal and protease sensitivity
Keywords: حلقه مرکز واکنش; Serpin; Corticosteroid; Hormone binding protein; Transcortin; Cortisol; Elastase; Reactive center loop; Heat sensitivity; CBG Lyon
Molecular and structural basis of steroid hormone binding and release from corticosteroid-binding globulin
Keywords: حلقه مرکز واکنش; Corticosteroid-binding globulin; Serpin; Reactive center loop; S to R transition; Neutrophil elastase
Crystal structure of SCCA1 and insight about the interaction with JNK1
Keywords: حلقه مرکز واکنش; Squamous cell carcinoma antigen 1; Serine proteinase inhibitor; c-Jun NH2-terminal kinase; Reactive center loop
Redirection of the reaction between activated protein C and a serpin to the substrate pathway
Keywords: حلقه مرکز واکنش; α1AT; α1-antitrypsin; APC; activated protein C; DIC; disseminated intravascular coagulation; mAb; monoclonal antibody; NBD; N-((2-(iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz-2-oxa-3-diazole; NBD P9 PAI-1; Ser338Cys (position P9 of RCL) mutant variant
Biochemical properties of an intracellular serpin from Echinococcus multilocularis
Keywords: حلقه مرکز واکنش; serpinEmu, serpin of Echinococcus multilocularis; RCL, reactive center loop; N-Cl-Suc, N-chloro-succinimide; PE, pancreatic elastase; NE, neutrophil elastaseEchinococcus; Multilocularis; Serpin; Intracellular; Recombinant; Reactive center loop; RCL
Transition of ovalbumin to thermostable structure entails conformational changes involving the reactive center loop
Keywords: حلقه مرکز واکنش; Ovalbumin; Thermostability; Reactive center loop; Serpin; Gallus gallus
Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site
Keywords: حلقه مرکز واکنش; AT; antithrombin; RCL; reactive center loop; fXa; factor Xa; fIXa; factor IXa; H5; pentasaccharide; SI; stoichiometry of inhibition; Serpin; Protease; Allostery; Hemostasis; Thrombosis;
PEDF and the serpins: Phylogeny, sequence conservation, and functional domains
Keywords: حلقه مرکز واکنش; PEDF; Serpins; Bioinformatics tools; Protein alignment; Reactive center loop; Peptides; Structure-function relationships; Heparin binding; Nuclear localization signal; Glycosylation;