New insights into TGF-β/Smad signaling in tissue fibrosis
Keywords: فیبروز کلیوی; TGF-β; Smad; Renal fibrosis; Pulmonary fibrosis; Cardiac fibrosis; Cancer;
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Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption
Keywords: فیبروز کلیوی; CHOP; ER stress; Autophagy; Microtubule; Apoptosis; Renal fibrosis;
YB-1 increases glomerular, but decreases interstitial fibrosis in CNI-induced nephropathy
Keywords: فیبروز کلیوی; Calcineurin inhibitor; Renal fibrosis; YB-1; CNI-induced nephropathy; Subcellular shuttling; YB-1; Y-box protein-1; CNI; calcineurin inhibitor; MC; mesangial cell;
Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation
Keywords: فیبروز کلیوی; Renin-angiotensin system; Epithelial-to-mesenchymal transition; Kidney proximal tubular epithelial cells; Renal fibrosis; Alismatis rhizoma; 25-O-methylalisol F; ACE; renin, angiotensin-converting enzyme; ACEI; angiotensin-converting enzyme inhibitors; AG
Intravoxel incoherent motion diffusion-weighted imaging for the assessment of renal fibrosis of chronic kidney disease: A preliminary study
Keywords: فیبروز کلیوی; Chronic kidney disease; Magnetic resonance imaging; Intravoxel incoherent motion diffusion-weighted imaging; Renal fibrosis;
The glucagon-like peptide-1 (GLP-1) analog liraglutide attenuates renal fibrosis
Keywords: فیبروز کلیوی; CKD; chronic kidney disease; ESRD; end-stage renal disease; UUO; unilateral ureteral obstruction; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; GLP-1; glucagon-like peptide-1; GLP-1R; glucagon-like peptide-1 receptor; TGF-β1; transfo
TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis
Keywords: فیبروز کلیوی; Renal fibrosis; Sox9; TGF-β; Kidney fibroblast; miR-30;
Therapeutic activity of the histone deacetylase inhibitor SB939 on renal fibrosis
Keywords: فیبروز کلیوی; Renal fibrosis; TGF-beta; Myofibroblast; HDAC inhibitor;
Slit2 ameliorates renal inflammation and fibrosis after hypoxia-and lipopolysaccharide-induced epithelial cells injury in vitro
Keywords: فیبروز کلیوی; Slit2; Hypoxia; Inflammation; Renal fibrosis;
Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats
Keywords: فیبروز کلیوی; Traditional Chinese Medicine; Hyperuricemic nephropathy; Renal fibrosis; Epithelial-to-mesenchymal transition;
Renoprotective effect of fucoidan from Acaudina molpadioides in streptozotocin/high fat diet-induced type 2 diabetic mice
Keywords: فیبروز کلیوی; Acaudina molpadioides; Fucoidan; Renal fibrosis; Kidney protection; Transforming growth factor-β1; Am-FUC; fucoidan from Acaudina molpadioides; CAT; catalase; DKD; diabetic kidney disease; ECM; extracellular matrix; GBM; glomerular basement membrane; GPX
Targeted disruption of Cd40 in a genetically hypertensive rat model attenuates renal fibrosis and proteinuria, independent of blood pressure
Keywords: فیبروز کلیوی; CD40; hypertensive renal disease; hypertension; renal fibrosis; renal function;
c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling
Keywords: فیبروز کلیوی; angiotensin II; c-Myc; integrin; renal fibroblasts; renal fibrosis; transforming growth factor-β;
Arctigenin suppresses renal interstitial fibrosis in a rat model of obstructive nephropathy
Keywords: فیبروز کلیوی; Arctigenin; Renal fibrosis; Inflammation; Transforming growth factor-β1; Oxidative stress; Epithelial-mesenchymal transition; α-SMA; α-smooth muscle actin; ANOVA; analysis of variance; ATG; arctigenin; BCA; bicinchoninic acid; BUN; blood urea nitrogen;
Murine recombinant angiotensin-converting enzyme 2 attenuates kidney injury in experimental Alport syndrome
Keywords: فیبروز کلیوی; Alport syndrome; angiotensin-converting enzyme 2; renal fibrosis; renin-angiotensin system; TNFα-converting enzyme;
Inflammatory cell infiltration and resolution of kidney inflammation is orchestrated by the cold-shock protein Y-box binding protein-1
Keywords: فیبروز کلیوی; chemokines; cold shock proteins; inflammation; interstitial nephritis; macrophages; phagocytosis; renal fibrosis;
Association of circulatory asymmetric dimethylarginine (ADMA) with diabetic nephropathy in Asian Indians and its causative role in renal cell injury
Keywords: فیبروز کلیوی; ADMA; Nitric oxide; Diabetic nephropathy; Renal fibrosis;
Connexin43 regulates high glucose-induced expression of fibronectin, ICAM-1 and TGF-β1 via Nrf2/ARE pathway in glomerular mesangial cells
Keywords: فیبروز کلیوی; AGEs; advanced glycation end products; ARE; anti-oxidant response element; Cx43; connexin43; DN; diabetic nephropathy; ECM; extracellular matrix; EMSA; electrophoretic mobility shift assay; FN; fibronectin; GMCs; glomerular messangial cells; GJIC; Gap jun
Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression
Keywords: فیبروز کلیوی; Brd4; Renal fibrosis; Nox4; TGF-β1;
Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2
Keywords: فیبروز کلیوی; LMWF; Low-molecular-weight fucoidan; F0.5; 0.5âM NaCl fraction; F1.0; 1.0âM NaCl fraction; EMT; Epithelial mesenchymal transition; TGF-β1; Transforming growth factor-β1; FGF-2; Fibroblast growth factor-2; HPSE; Heparanase; ECM; Extracellular matrix;
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis
Keywords: فیبروز کلیوی; CKD; chronic kidney disease; UUO; unilateral ureteral occlusion; TGFβ; transforming growth factor-beta; DNMT; DNA methyltransferase; MTD; myofibroblast trans-differentiation; MSP; methylation-specific PCR; BSP; bisulfite-sequencing PCR; Renal fibrosis; K
Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption
Keywords: فیبروز کلیوی; Emodin self-emulsifying; Cellular uptake; Advanced glycation-end products; Glomerular mesangial cells; Renal fibrosis; Emodin (Pubchem CID: 3220); 1,8-Dihydroxyanthraquinone (Pubchem CID: 2950);
10-DHGD ameliorates cisplatin-induced nephrotoxicity in rats
Keywords: فیبروز کلیوی; Nephrotoxicity; Cisplatin; Renal fibrosis; 10-Dehydrogingerdione
Arecoline-induced pro-fibrotic proteins in LLC-PK1 cells are dependent on c-Jun N-terminal kinase
Keywords: فیبروز کلیوی; CKD; chronic kidney disease; TGF-β; transforming growth factor-β; JNK; c-Jun N-terminal kinase; PAI1; plasminogen activator inhibitor-1; COX2; cyclooxygenase 2; AN; areca nut; ERK; extracellular signal-regulated kinase; DMSO; dimethylsulfoxide; MTT; 3-(
Research ArticleElucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis
Keywords: فیبروز کلیوی; Renal fibrosis; NRF-1;
Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice
Keywords: فیبروز کلیوی; Angiotensin-converting enzyme 2; mTOR; Renal fibrosis; Apolipoprotein E; Atherosclerosis
Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway
Keywords: فیبروز کلیوی; Renal fibrosis; Spleen tyrosine kinase (Syk); Transforming growth factor-β1; MAPK; Unilateral ureteral obstruction;
Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms
Keywords: فیبروز کلیوی; Renal fibrosis; TGF-β1; Smad3; Wogonin
The cellular and signalling alterations conducted by TGF-β contributing to renal fibrosis
Keywords: فیبروز کلیوی; Chronic kidney disease; Renal fibrosis; Myofibroblast; Transforming growth factor;
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease
Keywords: فیبروز کلیوی; glomerular hypertrophy; HIF-1α; inflammation; proximal tubule; renal fibrosis; renal hypoperfusion; VEGF;
Short Hairpin RNA Knockdown of Connective Tissue Growth Factor by Ultrasound-Targeted Microbubble Destruction Improves Renal Fibrosis
Keywords: فیبروز کلیوی; Ultrasound-targeted microbubble destruction; Sonoporation; Cationic microbubbles; Renal fibrosis; Unilateral ureteral obstruction; Connective tissue growth factor; Transforming growth factor-β; Gene delivery; RNA interfering; Short hairpin RNA;
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis
Keywords: فیبروز کلیوی; C5aR1; chronic inflammation; pyelonephritis; renal fibrosis;
Downregulation of miR-30c promotes renal fibrosis by target CTGF in diabetic nephropathy
Keywords: فیبروز کلیوی; Diabetic nephropathy (DN); MicroRNAs (miRs); Connective tissue growth factor (CTGF); Renal fibrosis; Renal structure and function;
Transforming growth factor β1 is better than α smooth muscle actin for the prediction of renal fibrosis in patients with nephritic lupus
Keywords: فیبروز کلیوی; lupus nephritis; renal fibrosis; urinary α smooth muscle actin; urinary transforming growth factor β1
KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice
Keywords: فیبروز کلیوی; Unilateral ureteral obstruction; Caffeamide; Renal fibrosis; Obstructive nephropathy;
Application of GC-MS coupled with chemometrics for scanning serum metabolic biomarkers from renal fibrosis rat
Keywords: فیبروز کلیوی; Biomarker; Chemometrics; Gas chromatography-mass spectrometry; Metabolites; Renal fibrosis;
Ethanolic Ginkgo biloba leaf extract prevents renal fibrosis through Akt/mTOR signaling in diabetic nephropathy
Keywords: فیبروز کلیوی; Diabetic nephropathy; Renal fibrosis; Akt; mTOR; Ethanolic ginkgo biloba extractα-SMA, α-smooth muscle actin; AGC, cAMP-dependent, cGMP-dependent and protein kinase C; BCA, bicinchoninic acid; BSA, albumin from bovine serum; BUN, blood urea nitrogen; CMC–
Implication des microARN dans la fibrose rénale
Keywords: فیبروز کلیوی; Biomarqueur; Fibrose rénale; MicroARNBiomarkers; MicroRNA; Renal fibrosis
Myeloid HIF-1 attenuates the progression of renal fibrosis in murine obstructive nephropathy
Keywords: فیبروز کلیوی; Hypoxia-inducible factor; Renal fibrosis; Macrophage
Tanshinone IIA attenuates renal fibrosis and inflammation via altering expression of TGF-β/Smad and NF-κB signaling pathway in 5/6 nephrectomized rats
Keywords: فیبروز کلیوی; Tanshinone IIA; Chronic kidney disease; Renal fibrosis
Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats
Keywords: فیبروز کلیوی; Diabetic nephropathy; Berberine; MMPs/TIMPs system; ECM; Renal fibrosis
Participation of bone morphogenetic protein (BMP)-6 and osteopontin in cisplatin (CDDP)-induced rat renal fibrosis
Keywords: فیبروز کلیوی; BMP-6; Cisplatin; Osteopontin; Renal fibrosis;
Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid
Keywords: فیبروز کلیوی; Diabetic nephropathy; Huangkui capsule; Renal fibrosis; Oxidative stress; p38MAPK signaling pathway; Akt signaling pathway;
Gliotoxin from Aspergillus fumigatus reverses epithelial to mesenchymal transition: Implications in renal fibrosis
Keywords: فیبروز کلیوی; Renal fibrosis; Gliotoxin; Epithelial-mesenchymal transition; Kidney; HK-2; ROS;
Protection from renal fibrosis, putative role of TRIB3 gene silencing
Keywords: فیبروز کلیوی; TRIB3; siRNA; MAPK; Renal fibrosis
CD2AP mRNA in urinary exosome as biomarker of kidney disease
Keywords: فیبروز کلیوی; Urine; Exosome; Podocyte; Renal fibrosis; mRNA; Biomarker
Wnt/β-catenin signaling and kidney fibrosis
Keywords: فیبروز کلیوی; β-catenin; fibroblasts; proteinuria; renal fibrosis; Wnt
The role of adenosine receptors A2A and A2B signaling in renal fibrosis
Keywords: فیبروز کلیوی; cell signaling; chronic renal disease; fibrosis; inflammation; renal fibrosis;
Sedum sarmentosum Bunge extract exerts renal anti-fibrotic effects in vivo and in vitro
Keywords: فیبروز کلیوی; Sedum sarmentosum Bunge; Epithelial-to-mesenchymal transition; Matrix accumulation; Transforming growth factor-β1; Renal fibrosis;
Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice
Keywords: فیبروز کلیوی; Alport syndrome; Renal fibrosis; Integrins; Collagen receptors; Type IV collagen;