Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction
Keywords: فیبروز کلیوی; JAK; STAT; SOCS; Renal fibrosis; MMP-2; UUO
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Antiproteinuric effect of pirfenidone in a rat model of anti-glomerular basement membrane glomerulonephritis
Keywords: فیبروز کلیوی; Renal fibrosis; Proteinuria; Pirfenidone; Podocyte; Glomerular injury
Plasmid pUDK-HGF encoding human hepatocyte growth factor gene attenuates gentamicin-induced kidney injury in rats
Keywords: فیبروز کلیوی; Hepatocyte growth factor; Kidney injury; Renal fibrosis; Gene therapy;
Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats
Keywords: فیبروز کلیوی; Cordyceps sinensis; Renal fibrosis; TGF-β1;
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
Keywords: فیبروز کلیوی; α-SMA; α-smooth muscle actin; EMT; epithelial-to-mesenchymal transition; FSP-1; fibroblast-specific protein 1; HIF-1α; hypoxia-inducible factor 1α; PHD; prolyl hydroxylase domain; TFIID; transcription factor II D; TGF-β1; transforming growth factor b
Basic ResearchRAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation
Keywords: فیبروز کلیوی; ICAM-1; NF-κB; RAGE; renal fibrosis; unilateral ureteral obstruction;
Pentamethylquercetin ameliorates fibrosis in diabetic Goto-Kakizaki rat kidneys and mesangial cells with suppression of TGF-β/Smads signaling
Keywords: فیبروز کلیوی; Pentamethylquercetin; Diabetic nephropathy; Renal fibrosis; Goto-Kakizaki Rats; Mesangial cell; TGF-β/Smads signaling;
Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis
Keywords: فیبروز کلیوی; extracellular matrix; obstructive nephropathy; renal fibrosis; TGF-β;
The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts
Keywords: فیبروز کلیوی; TGF-β1; transforming growth factor-β1; ECM; extracellular matrix; PI3K-Akt; phosphatidyl inositol 3 kinase-protein kinase B; MEK-Erk1/2; mitogen activated protein kinase 2-extracellular signal regulated kinase 1/2; Ras proteins; PI3K/Akt; MEK/ERK 1/2; T
A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis
Keywords: فیبروز کلیوی; microRNA; mitochondria; renal fibrosis; tubular epithelial cell; UCP2;
Inhibition of TGF-β1-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis
Keywords: فیبروز کلیوی; glycosylation; obstructive nephropathy; receptors; renal fibrosis; transforming growth factor-beta; unilateral urethral obstruction;
Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: Implications for cardiorenal syndromeâ
Keywords: فیبروز کلیوی; Cardiorenal syndrome; Myocardial infarction; Subtotal nephrectomy; Cardiac remodeling; Renal fibrosis;
The microRNA miR-433 promotes renal fibrosis by amplifying the TGF-β/Smad3-Azin1 pathway
Keywords: فیبروز کلیوی; microRNA therapy; miR-433; renal fibrosis; TGF-β signaling;
Novel evidence demonstrates that epithelial-mesenchymal transition contributes to nephrolithiasis-induced renal fibrosis
Keywords: فیبروز کلیوی; Kidney; Nephrolithiasis; Twist; Renal fibrosis; Epithelial-mesenchymal transition
Antifibrotic effect of synthetic Smad/Sp1 chimeric decoy oligodeoxynucleotide through the regulation of epithelial mesenchymal transition in unilateral ureteral obstruction model of mice
Keywords: فیبروز کلیوی; Renal fibrosis; EMT; Smad; Sp1; TGF-β1; Decoy oligodeoxynucloeotide
Rapamycin is less fibrogenic than Cyclosporin A as demonstrated in a rat model of chronic allograft nephropathy
Keywords: فیبروز کلیوی; Cyclosporin A; Rapamycin; Renal fibrosis; Chronic allograft nephropathy; Kidney transplantation
Overview of the Physiology and Pathophysiology of Leptin With Special Emphasis on its Role in the Kidney
Keywords: فیبروز کلیوی; Hyperleptinemia; leptin resistance; obesity; renal fibrosis
Epigenetics of Progression of Chronic Kidney Disease: Fact or Fantasy?
Keywords: فیبروز کلیوی; DNA methylation; microRNAs; chronic kidney disease (CKD); EMT; renal fibrosis
Molecular mechanisms in the pathogenesis of diabetic nephropathy: An update
Keywords: فیبروز کلیوی; Diabetic nephropathy; Renal fibrosis; Target site; Signaling pathways
Stress oxydant et effets bénéfiques rénaux de la restriction sodée dans l’insulinorésistance chez le rat
Keywords: فیبروز کلیوی; Fructose; Anion superoxyde; Fibrose rénale; AlbuminurieFructose; Superoxide anion; Renal fibrosis; Albuminuria
Smad3 linker phosphorylation attenuates Smad3 transcriptional activity and TGF-β1/Smad3-induced epithelial–mesenchymal transition in renal epithelial cells
Keywords: فیبروز کلیوی; Smad3 phosphorylation; TGF-β1-induced EMT; Renal fibrosis
TGF-β/Smad Signaling in Kidney Disease
Keywords: فیبروز کلیوی; Chronic kidney disease; TGF-β/Smad signaling; renal fibrosis; renal inflammation;
The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch–induced growth factor expression in renal tubules
Keywords: فیبروز کلیوی; CTGF; mechanical stretch; Pyk2; renal fibrosis; TGF-β1
The role of IL-7 in renal proximal tubule epithelial cells fibrosis
Keywords: فیبروز کلیوی; High glucose; IL-7; Renal fibrosis; Smads; EMT
Novel insights into pericyte–myofibroblast transition and therapeutic targets in renal fibrosis
Keywords: فیبروز کلیوی; endothelial cell; macrophage; myofibroblast; pericyte; renal fibrosis
Hemizygous deletion of CTGF/CCN2 does not suffice to prevent fibrosis of the severely injured kidney
Keywords: فیبروز کلیوی; Renal fibrosis; Connective Tissue Growth Factor; STZ induced nephropathy; Unilateral ureter obstruction; Aristolochic acid induced nephropathy
Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis
Keywords: فیبروز کلیوی; EMT; Id1; inflammation; renal fibrosis; TGF-β1;
Purple corn anthocyanins dampened high-glucose-induced mesangial fibrosis and inflammation: possible renoprotective role in diabetic nephropathy
Keywords: فیبروز کلیوی; CTGF; connective tissue growth factor; DMEM; Dulbecco's modified Eagle's media; DN; diabetic nephropathy; ECM; extracellular matrix; FBS; fetal bovine serum; HG; high glucose; HRMC; human renal mesangial cells; ICAM-1; intracellular cell adhesion molecule
Thrombospondin-1 plays a profibrotic and pro-inflammatory role during ureteric obstruction
Keywords: فیبروز کلیوی; renal fibrosis; renal progression; TGF-β;
The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice
Keywords: فیبروز کلیوی; chronic kidney disease; prostaglandins; renal fibrosis;
Nicousamide, a potent inhibitor of phosphorylation by TGF-β receptor II
Keywords: فیبروز کلیوی; Nicousamide; Renal fibrosis; Phosphorylation; TGF-β receptor II
Calcimimetics inhibit renal pathology in rodent nephronophthisis
Keywords: فیبروز کلیوی; calcium-sensing receptor; polycystic kidney disease; renal fibrosis; renal pathology
Origin of new cells in the adult kidney: results from genetic labeling techniques
Keywords: فیبروز کلیوی; acute renal failure; renal fibrosis; renal stem cell
The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy
Keywords: فیبروز کلیوی; Transforming growth factor beta; Epithelial to mesenchymal transition; Renal fibrosis; Diabetic nephropathy
Presence of bioactive lysophosphatidic acid in renal effluent of rats with unilateral ureteral obstruction
Keywords: فیبروز کلیوی; Lysophospholipase D; Lysophospholipid; Lysophosphatidylcholine; Renal fibrosis
Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis
Keywords: فیبروز کلیوی; fibroblast; obstructive nephropathy; renal fibrosis;
Cell division autoantigen 1 enhances signaling and the profibrotic effects of transforming growth factor-β in diabetic nephropathy
Keywords: فیبروز کلیوی; diabetic nephropathy; renal fibrosis; TGF-β
Transcriptional inhibition of progressive renal disease by gene silencing pyrrole–imidazole polyamide targeting of the transforming growth factor-β1 promoter
Keywords: فیبروز کلیوی; chronic kidney disease; gene therapy; renal fibrosis; TGF-β; transcription regulation
Platelet-derived growth factor receptor signaling activates pericyte–myofibroblast transition in obstructive and post-ischemic kidney fibrosis
Keywords: فیبروز کلیوی; endothelium; fibroblast; pathophysiology of renal disease and progression; renal fibrosis; TGF-β
Imagerie et insuffisance rénale : de l'inflammation à la fibrose
Keywords: فیبروز کلیوی; Néphropathie aiguë; Néphropathie chronique; Fibrose rénale; Particules d'oxyde de fer; IRM; Ãlastographie; Acute nephropathy; Chronic nephropathy; Renal fibrosis; Ironoxide particles; MRI; Elastography;
Lefty antagonises TGF-β1 induced epithelial–mesenchymal transition in tubular epithelial cells
Keywords: فیبروز کلیوی; Renal fibrosis; E-cadherin; α-Smooth muscle actin; Smad; JNK; p38
Effect of the inosine 5′-monophosphate dehydrogenase inhibitor BMS-566419 on renal fibrosis in unilateral ureteral obstruction in rats
Keywords: فیبروز کلیوی; IMPDH; BMS-566419; MMF; UUO; Renal fibrosis; Collagen; MCP-1; TGF-β1
PPARα agonist fenofibrate protects the kidney from hypertensive injury in spontaneously hypertensive rats via inhibition of oxidative stress and MAPK activity
Keywords: فیبروز کلیوی; Peroxisome proliferator-activated receptor α; Hypertension; Renal fibrosis; Oxidative stress; Inflammation; MAPK
Renoprotective properties of pirfenidone in subtotally nephrectomized rats
Keywords: فیبروز کلیوی; Chronic kidney disease; Pirfenidone; Renal fibrosis; Epithelial–mesenchymal transition; α-SMA
Chronic cadmium exposure induces transcriptional activation of the Wnt pathway and upregulation of epithelial-to-mesenchymal transition markers in mouse kidney
Keywords: فیبروز کلیوی; Cadmium; Wnt; Frizzled; EMT; Renal fibrosis; Cancer
Suppression of renal fibrosis by galectin-1 in high glucose-treated renal epithelial cells
Keywords: فیبروز کلیوی; Diabetes; Galectin-1; Renal fibrosis; Smad3; Mitogen-activated protein kinase; TGF-β1
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease
Keywords: فیبروز کلیوی; Type IV collagen; Collagen receptors; Alport syndrome; Renal fibrosis; Hereditary kidney disease
Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro
Keywords: فیبروز کلیوی; Ginsenoside Rg1; Transforming growth factor-β1 (TGF-β1); Renal fibrosis; Epithelial-myofibroblast transition (EMT); Extracellular matrix (ECM); Extracellular signal-regulated kinase (ERK)
Mast cells decrease renal fibrosis in unilateral ureteral obstruction
Keywords: فیبروز کلیوی; mast cells; renal fibrosis; ureteral obstruction
Le stress du réticulum endoplasmique au cours des néphropathies : une question de vie et de mort ?
Keywords: فیبروز کلیوی; Stress du réticulum endoplasmique; Néphropathie chronique; Fibrose; Transition épithélio-mésenchymateuse; ApoptoseEndoplasmic reticulum stress; Unfolded protein response; Chronic nephropathy; Renal fibrosis; Epithelial to mesenchymal transition; Apoptosis