Keywords: رین کیناز; Pancreatic Cancer; Stromal Remodeling; Invasion; Metastasis; Diagnostic Tool; Patient-Derived Models; ACTA; α-smooth muscle actin; CAF; cancer-associated fibroblasts; cEV; circulating extracellular vesicle; ECM; extracellular matrix; HA; hyaluronic acid;
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Keywords: رین کیناز; Curcumin; Polymer Therapeutics; Spinal cord injury; Ependymal progenitor stem cells; Rho kinase;
Design, synthesis, immunocytochemistry evaluation, and molecular docking investigation of several 4-aminopyridine derivatives as potential neuroprotective agents for treating Parkinson's disease
Keywords: رین کیناز; Neuroprotective agents; Parkinson's disease; 4-Aminopyridine derivatives; α-Synuclein; Inflammation; Oxidative stress; Rho kinase;
Keywords: رین کیناز; Cerebral ischemia; Endothelial barrier permeability; Microparticles; TNF-α; Rho kinase; Apoptosis
Keywords: رین کیناز; Endothelial cell; Collective migration; Substrate stiffness; Rho kinase; Integrins;
Keywords: رین کیناز; 6-OHDA; 6-hydroxydopamine; ACE; angiotensin converting enzyme; ACEIs; ACE inhibitors; AII; angiotensin II; AT1; AII type 1 receptor; AT2; AII type 2 receptor; CNS; central nervous system; DA; dopamine; DPN; 2,3-Bis-4-hydroxyphenyl-propionitrile, ER-β ago
Keywords: رین کیناز; Corneal endothelium; Barrier function; Actomyosin; Rho GTPase; RhoA; Rho kinase; Thrombin; HCEC; human corneal endothelial cell; GTPase; guanosine triphosphatase; GTP; guanosine triphosphate; ROCK; Rho kinase; MRCK; myotonic dystrophy kinase-related Cdc42
Keywords: رین کیناز; Ductus arteriosus; Chicken; Oxygen; Rho kinase;
Keywords: رین کیناز; Fog; Folded gastrulation; TF; transcription factor; GPCR; G-protein coupled receptor; Mist; mesoderm invagination signal transducer; Cta; Concertina; RhoGEF; Rho guanine nucleotide exchange factor; Rok; Rho kinase; PMG; posterior midgut; GBE; germ band ex
Keywords: رین کیناز; mESC; mouse embryonic stem cell; FAK; focal adhesion kinase; LIF; leukaemia inhibitory factor; ROCK; rho kinase; pPAA; plasma polymerised acrylic acid; PLGA; poly(lactic-co-glycolic acid); Embryonic stem cells; Cell spreading; Biomaterials; E-cadherin; Rh
Keywords: رین کیناز; CD; cytochalasin D; F-actin; filamentous actin; MβCD; methyl-β cyclodextrin; MES; 4-Morpholineethanesulfonic acid; PAK-PBD; p21 binding domain of p21-activated kinase 1; Rhotekin-RBD; Rho binding domain of Rhotekin; ROCK; Rho kinase; Tyrp; tyrosine phos
ROCK inhibitors 3: Design, synthesis and structure-activity relationships of 7-azaindole-based Rho kinase (ROCK) inhibitors
Keywords: رین کیناز; 7-Azaindole; Solubilizing group; Structure-based design; Lipophilic efficiency; Rho kinase; ROCK;
Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis
Keywords: رین کیناز; Paeoniflorin; Rheumatoid arthritis; Rho kinase; Synovial tissue;
ROCK inhibitors 2. Improving potency, selectivity and solubility through the application of rationally designed solubilizing groups
Keywords: رین کیناز; Solubilizing group; Structure-based design; Rho kinase; ROCK;
Differential contribution of calcium channels to α1-adrenoceptor-mediated contraction is responsible for diverse responses to cooling between rat tail and iliac arteries
Keywords: رین کیناز; Cutaneous artery; Cooling; α1-adrenoceptor; Endothelium-derived relaxing factor; Rho kinase;
Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration
Keywords: رین کیناز; Wnt5b; Wnt10a; TAX1BP3; CDC42; Rhotekin; β-Catenin; ARHGEF; rhoA guanine nucleotide exchange factor; CDC42; cell division cycle 42; CNS; central nervous system; daam1; disheveled-associated activator of morphogenesis 1; DAPI; 4â²,6-diamidino-2-phenylind
Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke
Keywords: رین کیناز; 5α-DHP; 5α-dihydroprogestrone; ABC; ATP-binding cassette; AF6; ALL-1-fused gene from chromosome 6; ALL; acute lymphoblastic leukemia; AMPAR; amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor; Ang-1; angiopoietin-1; AP-1; activator protein-1; BBB;
Comparison of signalling mechanisms underlying UTP-evoked vasoconstriction of rat pulmonary and tail arteries
Keywords: رین کیناز; P2Y receptor; Pulmonary artery; Tail artery; Ca2+; Rho kinase; Protein kinase C;
Deoxycholylglycine, a conjugated secondary bile acid, reduces vascular tone by attenuating Ca2+ sensitivity via rho kinase pathway
Keywords: رین کیناز; Bile acids; Vascular tone; Vascular dysfunction; Cirrhosis; Rho kinase; Deoxycholylglycine (DCG);
Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension
Keywords: رین کیناز; ADRF; adipocyte-derived relaxing factor; AE; anion exchanger; ATP; adenosine triphosphate; BH4; tetrahydrobiopterin; BKCa; big conductance Ca2+-sensitive K+ channel; CaM; calmodulin; cAMP; cyclic adenosine monophosphate; CAT; cysteine aminotransferase; CB
Rho-kinase inhibitor treatment prevents pulmonary inflammation and coagulation in lipopolysaccharide-induced lung injury
Keywords: رین کیناز; Acute lung injury; (ALI); Lipopolysaccharide; (LPS); Human pulmonary microvascular endothelial cells; (HPMECs); Myeloperoxidase; (MPO); Interleukins 1-beta; (IL-1β); Interluekin-6; (IL-6); Nuclear factor; ((NF)-κB.); Tumor necrosis factor; (TNF)-α; Tis
Role of Rho-specific guanine nucleotide dissociation inhibitor α regulation in cell migration
Keywords: رین کیناز; Rho GEFs; Rho guanine nucleotide exchange factors; Rho GAPs; Rho GTPases activating protein; RhoGDIs; Rho-specific guanine nucleotide dissociation inhibitors; ROCK; Rho kinase; ER; estrogen receptor; HCC; hepatocellular carcinoma; ERM; Ezrin-radixin-moesi
Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells
Keywords: رین کیناز; Paeoniflorin; Lipid accumulation; Insulin resistance; Rho kinase;
Phosphatidylinositol 3-kinase inhibition induces vasodilator effect of sevoflurane via reduction of Rho kinase activity
Keywords: رین کیناز; Anesthetics; Phosphatidylinositol 3-kinase; Rho kinase; Sevoflurane;
Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway
Keywords: رین کیناز; Alzheimer's disease; BV2 cells; Neuroinflammation; Advanced glycation end products; Rho kinase;
Fluid shear stress applied by orbital shaking induces MG-63 osteosarcoma cells to activate ERK in two phases through distinct signaling pathways
Keywords: رین کیناز; FSS; fluid shear stress; PI3-kinase; phosphoinositide-3-kinase; Rho kinase; Rho-associated kinase; Mechanoresponse; Fluid flow; Shear stress; Osteoblast; Orbital shaking;
ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy
Keywords: رین کیناز; Spinal Muscular Atrophy; Motoneuron disease; Signaling; Rho kinase; ERK;
Rho kinase-dependent desensitization of GPR39; a unique mechanism of GPCR downregulation
Keywords: رین کیناز; GPR39-C3 (PubChem CID: 091826086); GSB-118 (PubChem CID: 003112012); G-protein-coupled receptor 39; Desensitization; Biased ligand; Positive allosteric modulator; Rho kinase;
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: رین کیناز; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Pretreatment with Rho-kinase inhibitor ameliorates lethal endotoxemia-induced liver injury by improving mitochondrial function
Keywords: رین کیناز; Rho kinase; Lipopolysaccharide; Liver injury; Sepsis; Mitochondrial dysfunction; Oxidative stress
Increased rho kinase activity in mononuclear cells of dialysis and stage 3–4 chronic kidney disease patients with left ventricular hypertrophy: Cardiovascular risk implications
Keywords: رین کیناز; Rho kinase; LVH; CKD; Dialysis; MYPT-1; Fasudil
Inhibition of RhoA/Rho kinase by ibuprofen exerts cardioprotective effect on isoproterenol induced myocardial infarction in rats
Keywords: رین کیناز; Rho kinase; Ibuprofen; Isoproterenol; ROCK-1
Simultaneous Rho kinase inhibition in circulating leukocytes and in cardiovascular tissue in rats with high angiotensin converting enzyme levels
Keywords: رین کیناز; ROCK; Rho kinase; ACE; angiotensin converting enzyme I; Ang II; angiotensin II; BN; Brown Norway strain; ERM; ezrin, radixin and moesin; p-ERM; phosphorylated ERM; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GRK2 or β-ARK1; G protein-coupled recepto
Cardiac glycoside-induced cell death and Rho/Rho kinase pathway: Implication of different regulation in cancer cell lines
Keywords: رین کیناز; Cardiac glycosides; Cell death; Migration; Rho kinase; Cancer
Rho-kinase signaling controls nucleocytoplasmic shuttling of class IIa Histone Deacetylase (HDAC7) and transcriptional activation of orphan nuclear receptor NR4A1
Keywords: رین کیناز; ROCK; Rho kinase; OPHN1; Oligophrenin-1; HDAC7; Histone Deacetylase 7; MYPT1; myosin phosphatase subunit 1; MLCP; myosin light chain phosphatase; MLCK; myosin light chain kinase; NR4A1; nuclear receptor subfamily 4, group A, member 1; iPSCs; induced pluri
Rho kinase mediates Porphyromonas gingivalis outer membrane vesicle-induced suppression of endothelial nitric oxide synthase through ERK1/2 and p38 MAPK
Keywords: رین کیناز; Rho kinase; Porphyromonas gingivalis; Outer membrane vesicle; Endothelial nitric oxide synthase
Retina derived relaxation is mediated by Kir channels and the inhibition of Ca2+ sensitization in isolated bovine retinal arteries
Keywords: رین کیناز; Retinal relaxing factor (RRF); Retinal artery; Ca2+ sensitization; Rho kinase; Kir channels;
The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration
Keywords: رین کیناز; Rho kinase; MRCK; Cell migration plasticity; ROCK and MRCK inhibitors; Anticancer therapeutics; Polypharmacology;
CDK5 knockdown in astrocytes provide neuroprotection as a trophic source via Rac1
Keywords: رین کیناز; CDK5; cyclin-dependent kinase; GLU; glutamate; AD; Alzheimer's disease; DIV; day in vitro; ROS; reactive oxygen species; BDNF; brain-derived neurotrophic factor; ROCK; Rho kinase; LDH; lactate dehydrogenase; G-LISA; GTP enzyme-linked immunosorbent assay;
Evidence of pleiotropy by statins: Leukocyte Rho kinase (ROCK) activity and pretreated statin before percutaneous coronary interventions are clinical vascular outcome predictors
Keywords: رین کیناز; Rho kinase; Statin; Inflammation; Percutaneous coronary intervention;
In vivo optimization of 2,3-diaminopyrazine Rho Kinase inhibitors for the treatment of glaucoma
Keywords: رین کیناز; Glaucoma; Rho Kinase; Pyrazine; IOP reduction
Promotion of mouse embryonic stem cell differentiation by Rho kinase inhibitor Y-27632
Keywords: رین کیناز; BSA; bovine serum albumin; DRG; dorsal root ganglion; ERK; extracellular signal-regulated kinase; ES; embryonic stem; NGF; nerve growth factor; PBS; phosphate-buffered saline; ROCK; Rho kinase; Differentiation; Embryonic stem cell; Muscle cell; Neuron; RO
Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension
Keywords: رین کیناز; Rho kinase; Inhibitors; Lymphocyte depletion; Pulmonary arterial hypertension; Intra-tracheal dosing
Moesin functionality in hypothermic liver preservation injury
Keywords: رین کیناز; ERM; ezrin radixin moesin; IPL; isolated perfused liver; UW; University of Wisconsin solution; SEC; sinusoidal endothelial cell; LDH; lactate dehydrogenase; FERM; protein 4.1, ezrin, radixin, moesin; LPA; lysophosphatidic acid; PKC; protein kinase C; ROK;
Treatment with a Rho Kinase Inhibitor Improves Survival from Graft-Versus-Host Disease in Mice after MHC-Haploidentical Hematopoietic Cell Transplantation
Keywords: رین کیناز; GVHD; Fasudil; Intestinal tract; Rho kinase; Haploidentical; Allogeneic
Mepivacaine-induced contraction involves increased calcium sensitization mediated via Rho kinase and protein kinase C in endothelium-denuded rat aorta
Keywords: رین کیناز; Mepivacaine (PubChem CID: 66070); Y-27632 (PubChem CID: 9901617); GF 109203X (PubChem CID: 2396); PD 98059 (PubChem CID: 4713); SP600125 (PubChem CID: 8515); SB 203580 (PubChem CID: 176155)Mepivacaine; Contraction; Calcium sensitization; Rho kinase; Prote
Regular ArticleA pivotal role of nonmuscle myosin II during microglial activation
Keywords: رین کیناز; ELC; essential light chain; LPS; lipoplysaccharide; MLCK; myosin light chain kinase; NM II; nonmuscle myosin II; NO; nitric oxide; RLC; regulatory light chain; ROCK; Rho kinase; TNFα; tumor necrosis factor α; Neuroinflammation; Microglial response; Cyto
Pulmonary, gastrointestinal and urogenital pharmacologyNovel effect of 2-aminoethoxydiphenylborate through inhibition of calcium sensitization induced by Rho kinase activation in human detrusor smooth muscle
Keywords: رین کیناز; Human detrusor smooth muscle; Permeabilization; α-toxin; 2-APB; Calcium desensitization; Rho kinase;
Activation of beta 1 but not beta 3 integrin increases cell traction forces
Keywords: رین کیناز; β1KO; β1-integrin null mouse embryonic fibroblast; β3KO; β3-integrin null mouse embryonic fibroblast; BSA; bovine serum albumin; ECM; extracellular matrix; FA; focal adhesion; FN; fibronectin; LPA; lysophosphatidic acid; mPAD; micropost array detector
Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney
Keywords: رین کیناز; EGF; GPER-1; NR3A1; NR3A2; Oestrogen; Renal circulation; Rho kinase;