Keywords: رتلرین; Rottlerin; Total synthesis; Phenol-aldehyde condensation; ortho-Quinone methide; Gram-scale;
مقالات ISI رتلرین (ترجمه نشده)
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Glandular hair constituents of Mallotus philippinensis Muell. fruit act as tyrosinase inhibitors: Insights from enzyme kinetics and simulation study
Keywords: رتلرین; Mallotus philippinensis; Rottlerin; Mallotophilippen A; Mallotophilippen B; Tyrosinase;
Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer
Keywords: رتلرین; Eukaryotic elongation factor-2; eEF-2 kinase; Lung cancer; Liposomes; Rottlerin; siRNA; Signaling; Survival; Tumorigenesis;
In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells
Keywords: رتلرین; Mitochondria; Gö 6976; Rottlerin; Time-resolved microscopy; Oxidative stress; Glutathione; Superoxide;
Protein kinases C as potential host targets for the inhibition of chikungunya virus replication
Keywords: رتلرین; Chikungunya virus; Prostratin; Protein kinase C; Sotrastaurin; Rottlerin;
Oxidant species are involved in T/B-mediated ERK1/2 phosphorylation that activates p53-p21 axis to promote KSHV lytic cycle in PEL cells
Keywords: رتلرین; KSHV; Kaposi's sarcoma-associated herpesvirus; B; butyrate; ERK; Extracellular Signal-regulated Kinase; MAPKs; Mitogen-Activated Protein Kinases; PD98059; ERK inhibitor; PEL; Primary Effusion Lymphoma; PKCs; protein kinases C; Q; quercetin; ROS; reactive
Synergism between PKCδ regulators hypericin and rottlerin enhances apoptosis in U87 MG glioma cells after light stimulation
Keywords: رتلرین; Glioma cell; Photodynamic therapy; Apoptosis; Hypericin; Rottlerin; Bcl-2;
Protein kinase C-δ inhibitor, Rottlerin inhibits growth and survival of mycobacteria exclusively through Shikimate kinase
Keywords: رتلرین; Mycobacteria; Shikimate kinase; Rottlerin; PKC-δ;
Inhibitions of mTORC1 and 4EBP-1 are key events orchestrated by Rottlerin in SK-Mel-28 cell killing
Keywords: رتلرین; Rottlerin; AMPK; mTOR; 4EBP-1; Autophagy; Protein synthesis; RPMI; Roswell Park Memorial Institute (RPMI); Becl-1; beclin-1; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; mTOR; mammalian target of rapamycin; raptor; regulatory-associate
Rottlerin, a polyphenolic compound from the fruits of Mallotus phillipensis (Lam.) Müll.Arg., impedes oxalate/calcium oxalate induced pathways of oxidative stress in male wistar rats
Keywords: رتلرین; Hyperoxaluria; PKCδ; Rottlerin; NADPH oxidase; Renal functionROS, reactive oxygen species; CaOx, calcium oxalate; PKCδ, protein kinase C δ; EG, ethylene glycol; ALP, Alkaline phosphatase; LDH, lactate dehydrogenase; SOD, superoxide dismutase; CAT, catalas
Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells
Keywords: رتلرین; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5â²-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β
Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice
Keywords: رتلرین; Rottlerin; Pancreatic cancer; Cancer prevention; Akt; Sonic Hedgehog; Notch
Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models
Keywords: رتلرین; Mallotus philippinensis; Rottlerin; Passive cutaneous anaphylaxis; Passive systemic anaphylaxis; Anaphylactic contraction; RBL-2H3; Phospholipase Cγ, Ca2+ imaging;
Development and validation of a RP-HPLC method for the simultaneous determination of Embelin, Rottlerin and Ellagic acid in Vidangadi churna
Keywords: رتلرین; Vidangadi churna; Embelin; Rottlerin; Ellagic acid; RP-HPLC
Rottlerin induces apoptosis of HT29 colon carcinoma cells through NAG-1 upregulation via an ERK and p38 MAPK-dependent and PKC δ-independent mechanism
Keywords: رتلرین; Rottlerin; NAG-1; Apoptosis; p53; Colon carcinoma cells;
Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells
Keywords: رتلرین; CSCs, cancer stem cells; PARR, (ADP-ribose) polymerase (PARP); PKC-δ, protein kinase C delta; ROTT, rottlerinAutophagy; Pancreatic cancer; Apoptosis; PI3K; AKT; Rottlerin; Atg7; Beclin1
Role of oxidative stress in methamphetamine-induced dopaminergic toxicity mediated by protein kinase Cδ
Keywords: رتلرین; Methamphetamine; PKC isozymes; PKCδ gene deletion; Rottlerin; Dopamine; Oxidative stress
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
Keywords: رتلرین; TrxR; thioredoxin reductase; PpIX; protoporphyrin IX; NMPP; N-methylprotoporphyrin; qHTS; quantitative high-throughput screening; DMSO; dimethyl sulfoxide; Screening assay; Thioredoxin reductase; Inhibitor; Substrate; Protoporphyrin IX; Rottlerin; Cancer;
PKCdelta is a positive regulator of chondrogenesis in chicken high density micromass cell cultures
Keywords: رتلرین; Rottlerin; MEK-ERK; Sox9; shRNA; Cartilage formation; BMP; bone morphogenic protein; BSA; bovine serum albumin; CaM-KIII; calcium/calmodulin dependent protein kinase III; CMF-PBS; calcium/magnesium free PBS; DAG; diacyl-glycerol; DMMB; dimethyl-methylen
Inhibition of protein kinase Cδ reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages
Keywords: رتلرین; Macrophage; mRNA decay; Protein kinase Cδ; Rottlerin; TNFα (tumour necrosis factor-α); TTP (tristetraprolin)
Rottlerin induces heme oxygenase-1 (HO-1) up-regulation through reactive oxygen species (ROS) dependent and PKC δ-independent pathway in human colon cancer HT29 cells
Keywords: رتلرین; Rottlerin; Heme oxygenase-1; PKC δ; NF-E2-related factor 2 (Nrf2); HT29 cells
Lead-induced accumulation of β-amyloid in the choroid plexus: Role of low density lipoprotein receptor protein-1 and protein kinase C
Keywords: رتلرین; Blood–CSF barrier; Lead or Pb; Aβ; LRP1; Choroid plexus; Protein kinase C; PKC-δ; Rottlerin
Role of protein kinase C-δ in angiotensin II induced cardiac fibrosis
Keywords: رتلرین; Angiotensin II; Collagen; Rottlerin; PKC-δ;
Integrin signaling and cell spreading alterations by rottlerin treatment of chick limb bud mesenchymal cells
Keywords: رتلرین; Rottlerin; Integrin β1; Wound-healing assay; Chondrogenic differentiation; Cellular condensation
Rottlerin activates AMPK possibly through LKB1 in vascular cells and tissues
Keywords: رتلرین; AMP-activated protein kinase (AMPK); LKB1; Rottlerin; Protein kinase C (PKC); PKCδ; Vascular tissues; Vascular smooth muscle cells (VSMCs);
Rottlerin inhibits the nuclear factor κB/Cyclin-D1 cascade in MCF-7 breast cancer cells
Keywords: رتلرین; Rottlerin; MCF-7 cells; Cyclin-D1; NFκB; CaMKII;
Protein kinase C δ regulates anti-apoptotic αB-crystallin in the retina of type 2 diabetes
Keywords: رتلرین; αBC phosphorylation; Retinal apoptosis; PKC δ; Rottlerin; Type 2 diabetes;
Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-δ-dependent mechanism
Keywords: رتلرین; Cholecystokinin; Protein kinase C; Pancreatic acini; Exocrine secretion; PKC inhibitors; Rottlerin
Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cδ
Keywords: رتلرین; PKCδ; ERK; Cisplatin; Apoptosis; DNA damage; Drug-resistance; Rottlerin; U0126; HeLa cells; siRNA;
Effect of rottlerin, a PKC-δ inhibitor, on TLR-4-dependent activation of murine microglia
Keywords: رتلرین; Rottlerin; Microglia; TLR-4; Nitric oxide; Phagocytosis;
Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205
Keywords: رتلرین; PKCδ; Apoptosis; Rottlerin; Bistratene A; Caspase-3; COLO 205;
Central role of PKCδ in glycoxidation-dependent apoptosis of human neurons
Keywords: رتلرین; Glycoxidative stress; NT2 neurons; Protein kinase Cδ; Apoptosis; Rottlerin; Antioxidants; Free radicals;
The PKC delta inhibitor, rottlerin, induces apoptosis of haematopoietic cell lines through mitochondrial membrane depolarization and caspases' cascade
Keywords: رتلرین; Mallotus philippinensis; Euphorbiaceae; Rottlerin; Apoptosis; Mitochondrial membrane potential; Cytochrome c; Caspase;