Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1
Keywords: BRET assay; MG63Â cells; Osteoblast; Runx2;
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miR-148a-3p regulates adipocyte and osteoblast differentiation by targeting lysine-specific demethylase 6b
Keywords: ALP; alkaline phosphatase; aP2; adipocyte protein 2; BMP2; bone morphogenetic protein 2; C/EBP; CCAAT/enhancer binding protein; Dlx5; distal-less homeobox 5; HDAC9; Histone deacetylase 9; miRNA; microRNA; MSC; mesenchymal stem cell; Osx; osterix; PBS; pho
Role of Runx2 in breast cancer-mediated bone metastasis
Keywords: Runx2; runt-related transcription factor 2; BRC; breast cancer gene; HER; herceptin; ER; estrogen; PR; progesterone; ECM; extra cellular matrix; EMT; epithelial mesenchymal transition; JAK/STAT; Janus Kinase; NFκB; nuclear factor kappa-B; MMP; matrix met
Comparative analysis of osteoblast gene expression profiles and Runx2 genomic occupancy of mouse and human osteoblasts in vitro
Keywords: NGS; next generation sequencing; ChIP; chromatin immunoprecipitation; ChIP-seq; chromatin immunoprecipitation followed by deep sequencing; TF; transcription factor; MSC; mesenchymal stem cell; DE; differentially expressed; TSS; transcriptional start site;
Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology
Keywords: ALP; alkalinephosphatase; BBB; blood-brain barrier; BMC; bone mineral content; BMD; bone mineral density; BW; body weight; CKD; chronic kidney disease; Col; collagen; CSF; cerebrospinal fluid; CT; calcitonin; DREE; dried Rehmanniae Radix alcohol extract
Translating calcified aortic valve disease to the bench - Use of 3D matrices in the development of future treatment strategies
Keywords: VIC; valvular interstitial cells; qVIC; quiescent VIC; pVIC; progenitor VIC; aVIC; activated VIC; oVIC; osteogenic VIC; VEC; valvular endothelial cells; CAVD; calcific aortic valve disease; ECM; extra-cellular matrix; α-SMA; alpha smooth muscle actin; TN
Expression of RUNX2 and MDM21 in rats with periodontitis under chronic intermittent hypoxia
Keywords: Chronic intermittent hypoxia; RUNX2; MDM21; Periodontitis
Tranilast stimulates endochondral ossification by upregulating SOX9 and RUNX2 promoters
Keywords: Endochondral ossification; Tranilast; SOX9; RUNX2;
Mesenchymal stem cell-induced 3D displacement field of cell-adhesion matrices with differing elasticities
Keywords: BIS; N,N-methylene-bis-acrylamide; CLSM; confocal laser scanning microscope; DVC; digital volume correlation; ECM; extracellular matrix; Eno2; enolase 2; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; hBMSC; human bone marrow MSC; mRNA; messenger RNA; M
ReviewSelective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers
Keywords: ChIP-seq; Mmp13; VDR; PTH; Histone modification; Osterix; Sp7; RUNX2; Vitamin D; 1,25(OH)2D3;
The interferon-inducible protein p205 acts as an activator in osteoblast differentiation of mouse BMSCs
Keywords: Interferon-inducible protein p205; Bone marrow stromal cells (BMSCs); Osteoblast differentiation; Runx2; Id proteins;
Insulin-like growth factor 1 promotes the proliferation and committed differentiation of human dental pulp stem cells through MAPK pathways
Keywords: ALP; alkaline phosphatase; a-MEM; a-minimum essential medium; BMPs; bone morphogenetic proteins; CPC; cetyl pyridinium chloride; DSP; dentin sialoprotein; DSPP; dentin sialophosphoprotein; ERK; extracellular regulated protein kinases; FBS; fetal bovine se
Full Length ArticleIncreased sensitivity of rheumatoid synoviocytes to Schnurri-3 expression in TNF-α and IL-17A induced osteoblastic differentiation
Keywords: FLS; fibroblast like synoviocytes; ALP; alkaline phosphatase; RA; rheumatoid arthritis; OA, AS; ankylosing spondylitis; OA; osteoarthritis; BMP-2; bone morphogenetic protein-2; Runx2; runt-related transcription factor-2; RANKL; receptor activator of nucle
Ddit3 suppresses the differentiation of mouse chondroprogenitor cells
Keywords: Sox9; sex determining region Y-type high mobility group box 9; C/EBP β; CCAAT/enhancer-binding protein β; GAG; proteoglycan; Col10a1; type X collagen; Runx2; runt related transcription factor 2; Col2a1; collagen II; Ddit3; DNA damage inducible transcrip
Root bark of Sambucus Williamsii Hance promotes rat femoral fracture healing by the BMP-2/Runx2 signaling pathway
Keywords: Root-bark of Sambucus Williamsii Hance; Fracture healing; Bone marrow stromal cells; BMP-2; BMPRs; Runx2
RUNX2 promotes breast cancer bone metastasis by increasing integrin α5-mediated colonization
Keywords: RUNX2; Integrin α5; Bone metastasis; Breast cancer;
Lamin A is involved in the development of vascular calcification induced by chronic kidney failure and phosphorus load
Keywords: Vascular calcification; Phosphorus load; Chronic kidney disease; Ageing; Runx2; Animal models; Proteomics; Lamin a;
Rapamycin Decreases the Osteogenic Response in Aortic Valve Interstitial Cells Through the Stat3 Pathway
Keywords: ALP; alkaline phosphatase; AVICs; aortic valve interstitial cells; BMP-2; bone morphogenetic protein 2; CAVD; calcific aortic valve disease; LPS; lipopolysaccharide; mTOR; mammalian target of rapamycin; RUNX2; runt-related transcription factor 2; Stat3; s
Modulation of MAPK signalling by immobilized adhesive peptides: Effect on stem cell response to BMP-9-derived peptides
Keywords: Integrin; Bone morphogenetic proteins; Cell signalling; Runx2
Full Length ArticleIn vitro lifespan and senescent behaviour of human periosteal derived stem cells
Keywords: MSCs; mesenchymal stem cells; BM-MSCs; bone marrow mesenchymal stem cells; AD-MSCs; adipose tissue derived mesenchymal stem cells; PDPCs; periosteum derived progenitor cells; NO; nitric oxide; SA-βgal; senescence associated β-galactosidase; Runx2; runt-
Original Full Length ArticleInhibition of TGFβ signaling decreases osteogenic differentiation of fibrodysplasia ossificans progressiva fibroblasts in a novel in vitro model of the disease
Keywords: FOP; fibrodysplasia ossificans progressiva; FCS; fetal calf serum; BMP; bone morphogenetic protein; TGFβ; transforming growth factor β; Runx2; runt-related transcription factor 2; Alp; alkaline phosphatase; OC; osteocalcin; ACVR1; activin receptor IA; A
WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
Keywords: VSMCs; vascular smooth muscle cells; AMC; arterial medial calcification; β-GP; β-glycerophosphoricacid; LRP; low density lipoprotein receptor-related protein; GSK; glycogen synthase kinase; PORCN; Porcupine; WNT/β-catenin signaling; Runx2; Vascular smo
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation
Keywords: Vascular smooth muscle cells; ZMPSTE24; Prelamin A; Senescence; Osteogenic transdifferentiation; Atherosclerosis; ALP; alkaline phosphatase; ATV; atazanavir; DRV; darunavir; HIV; human immunodeficiency virus; LPV; lopinavir; M/R; maraviroc/raltegravir; PB
AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis
Keywords: BMSC; bone marrow stromal cell; AMPK; AMP-activated protein kinase; OPN; osteopontin; Gfi1; growth factor independence-1; Runx2; runt-related transcription factor 2; Osx; Osterix; ALP; alkaline phosphatase; BSP; bone sialoprotein; OC; osteocalcin; PPARγ;
Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/β-catenin signaling pathway
Keywords: Berberine; Wnt; β-catenin; Runx2; Osteocalcin; Osteopontin
Characterization of BMP signaling dependent osteogenesis using a BMP depletable avianized bone marrow stromal cell line (TVA-BMSC)
Keywords: BMSC; BMP signaling; Bone; Cartilage; Osteogenesis; Chondrogenesis; Adipocytes; Klf10; Osx; Runx2;
Inhibition of miR-222-3p activity promoted osteogenic differentiation of hBMSCs by regulating Smad5-RUNX2 signal axis
Keywords: Mesenchymal stem cells; miR-222-3p; Smad5; RUNX2; Osteogenic differentiation;
17β-estradiol regulates the differentiation of cementoblasts via Notch signaling cascade
Keywords: Estrogen; Cementoblast; Notch; Bone sialoprotein; Runx2;
BCL11B regulates sutural patency in the mouse craniofacial skeleton
Keywords: BCL11B/CTIP2; Craniofacial development; Craniosynostosis; Midfacial hypoplasia; Fgfr2c; Runx2; Twist1;
Skp2 inhibits osteogenesis by promoting ubiquitin-proteasome degradation of Runx2
Keywords: Runx2; Osteoblast; Skp2; Polyubiquitination; Osteogenesis;
MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation
Keywords: miR; microRNA; HDAC; histone deacetylase; OA; osteoarthritis; COL2A1; collagen 2; SOX9; SRY (sex-determining region Y)-box 9; RUNX2; Runt-related transcription factor 2; HAT; histone acetyltransferase; TSA; trichostatin A; Mmp13; matrix metalloproteinase
Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus
Keywords: Runx2; Epigenetic regulation of gene expression; Hippocampus;
The functions of Runx family transcription factors and Cbfb in skeletal development
Keywords: Runx2; Cbfb; Chondrocytes; Osteoblasts; Enhancer;
Enterococcus faecalis Inhibits Osteoblast Differentiation and Induces Chemokine Expression
Keywords: Chemokine; Enterococcus faecalis; osteoblast; refractory apical periodontitis; Runx2
Runx2: Structure, function, and phosphorylation in osteoblast differentiation
Keywords: Runx2; Phosphorylation; Osteoblast; Bone;
Regulatory effects of fibroblast growth factor-8 and tumor necrosis factor-α on osteoblast marker expression induced by bone morphogenetic protein-2
Keywords: ALK; activin receptor-like kinase; ActRII; activin type-II receptor; ALP; alkaline phosphatase; BMP; bone morphogenetic protein; BMPRII; BMP type-II receptor; ERK; extracellular signal-regulated kinase; FGF; fibroblast growth factor; FGFR; FGF receptor; M
MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1
Keywords: Osteoblast differentiation; miR-194; STAT1; Runx2;
Osteogenic growth peptide promotes osteogenic differentiation of mesenchymal stem cells mediated by LncRNA AK141205-induced upregulation of CXCL13
Keywords: Alkaline phosphatase (ALP) activity; AK141205; Mesenchymal stem cells; Osteogenic growth peptide; Runx2;
In vitro inhibitory effects of terpenoids from Chloranthus multistachys on epithelial-mesenchymal transition via down-regulation of Runx2 activation in human breast cancer
Keywords: Chloranthus multistachys; Terpenoids; Istanbulin A; EMT; Runx2; In vitro;
Biomaterials mediated microRNA delivery for bone tissue engineering
Keywords: Biomaterial; MicroRNA; Runx2; Osteoblast; Bone;
Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells
Keywords: AR; aldose reductase; D-ELISA; DNA-based enzyme-linked immunosorbent assay; DTT; dithiothreitol; EMSA; electrophoretic mobility shift assay; HAdEC; human microvascular adipose-derived ECs (HAdEC); HBME; human bone marrow microvascular ECs; HG; hyperglycem
Original Full Length ArticleSIRT6 deficiency culminates in low-turnover osteopenia
Keywords: SIRT6; Osteopenia; Runx2; Osx; Osteoblast; Osteoclast;
Molecular characterization of cbfβ gene and identification of new transcription variants: Implications for function
Keywords: Transcription factor; Alternative splicing; cbfβ; Runx2; Functional analysis; Zebrafish;
Correlation between in vitro expansion-related cell stiffening and differentiation potential of human mesenchymal stem cells
Keywords: AFM; atomic force microscopy; ALP; alkaline phosphatase; β-MHC; β-myosin heavy chain; CNN1; calponin 1; Col 1; collagen 1; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; hMSCs; human mes
Synergy between IL-6 and soluble IL-6 receptor enhances bone morphogenetic protein-2/absorbable collagen sponge-induced bone regeneration via regulation of BMPRIA distribution and degradation
Keywords: BMP-2; IL-6; sIL-6R; BMPRIA; Bone regeneration; Cell surface translocation; BMP-2; bone morphogenetic protein-2; BMPRIA; bone morphogenetic protein receptor IA; BMPRIB; bone morphogenetic protein receptor IB; BMPRII; bone morphogenetic protein receptor II
Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis
Keywords: Runx2; Lansoprazole; Osteoblastogenesis; Drug repositioning; TRAF6; CYLD
Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies
Keywords: HA; hydroxyapatite; GAG; glycosaminoglycan; PG; proteoglycan; ECM; extracellular matrix; VEGF; vascular endotelial growth factor; HIF-1α; hypoxia-inducible factor-1 alpha; PDGF; platelet-derived growth factor; IL-1; interleukin 1; TNF; tumor necrosis fac
Analysis of vitamin D metabolism gene expression in human bone: Evidence for autocrine control of bone remodelling
Keywords: Vitamin D; CYP27B1; Bone; Osteocyte; Osterix; Runx2; Autocrine; Bone remodelling;
Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly in a Finnish woman: First confirmation of a duplication in RUNX2 as pathogenic variant
Keywords: Brachydactyly; Finland; Maxillary hypoplasia; Metaphyseal dysplasia; RUNX2;
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone
Keywords: RunX2; miR-30a-5p; Giant cell tumor of bone; Osteoclast differentiation