کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928328 1050347 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone
چکیده انگلیسی


• MiR-30a is down-regulated in GCT.
• MiE-30a directly regulates RunX2 by binding its 3′-UTR.
• MiR-30a shows regulatory role in osteolysis and bone resorption.

RunX2 has been identified to crucially regulate the osteolysis in giant cell tumor of bone. MiR-30a is an intronic miRNA identified as tumor suppressor, but little is known about its role in giant tumor cell of bone. In our research, we reported miR-30a was down-regulated in GCT whereas RunX2 was highly expressed. Further research proved that miR-30a can regulate the expression of RunX2 by binding to its 3′-UTR, which influence the osteoclast differentiation and osteolysis formation. Thus, these results suggest that miR-30a could directly target RunX2 and participate in osteolysis in GCT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 453, Issue 1, 10 October 2014, Pages 160–165
نویسندگان
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