Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; Toremifene; Tamoxifen; Metabolite kinetics; Bioactivation; CYP2D6; CYP3A4; CYP2C9; Pharmacogenomics; PolymorphismsTOR, toremifene; TAM, tamoxifen; SERM, selective estrogen receptor modulator; SSRI, selective serotonin reuptake inhibitor; 4OH, 4-hydroxy; N
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Synthesis of a spin-labeled anti-estrogen as a dynamic motion probe for the estrogen receptor ligand binding domain
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; ERα, estrogen receptor alpha; ERα-LBD, estrogen receptor alpha-ligand binding domain; AF2, activation function 2; SERM, selective estrogen receptor modulator; NMR, nuclear magnetic resonance; EPR, electron paramagnetic resonance; SDSL, site directed spin
Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; dpf, days post-fertilization; EM, embryo medium; GTTR, gentamicin-Texas Red; MIC, minimum inhibitory concentration; MBC, minimum bactericidal concentration; SERM, selective estrogen receptor modulator; SSRI, selective serotonin reuptake inhibitor
Estradiol and tamoxifen differentially regulate a plasmalemmal voltage-dependent anion channel involved in amyloid-beta induced neurotoxicity
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; SERM, selective estrogen receptor modulator; IGF-1R, insulin growth factor-1 receptor; CSD, caveolar scaffolding domain; PKA, protein kinase AVoltage-dependent anion channel; Estrogen receptor; 17β-Estradiol; Tamoxifen; Lipid rafts; Amyloid beta
Toremifene Decreases Vertebral Fractures in Men Younger Than 80 Years Receiving Androgen Deprivation Therapy for Prostate Cancer
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; prostate; prostatic neoplasms; toremifene; thromboembolism; fractures, boneADT, androgen deprivation therapy; AE, adverse event; BMD, bone mineral density; ITT, intent to treat; MITT, modified ITT; SERM, selective estrogen receptor modulator; VTE, venous
Importance of cholesterol and oxysterols metabolism in the pharmacology of tamoxifen and other AEBS ligands
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; AEBS, microsomal antiestrogen binding site; ER, estrogen receptor; PR, progesterone receptor; SERM, selective estrogen receptor modulator; Tam, tamoxifen; ACAT, Acyl-coA:Cholesterol Acyl-Transferase; SOAT, sterol O-acyltransferase; D8D7I, 3β-hydroxysterol
Identifying Factors Associated With Falls in Postmenopausal Breast Cancer Survivors: A Multi-Disciplinary Approach
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; Drug therapy; Muscle strength; Neoplasms; Postural balance; RehabilitationAI, aromatase inhibitor; BCS, breast cancer survivors; SERM, selective estrogen receptor modulator; SOT, sensory organization test
The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; SERM, selective estrogen receptor modulator; EC, endometrial cancer; TAM, tamoxifen; RAL, raloxifene; EM1, nonmalignant immortalized human endometrial glandular cell line; EM, estrogen/estrogen metabolites; E2, estradiol; E1, estrone; HPLC–ESI-MS2, high p
High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; ER, estrogen receptor α; EDC, endocrine disrupting chemical; NR, nuclear receptor; ERE, estrogen response element; DES, diethylstilbestrol; SERM, selective estrogen receptor modulator; 4HT, 4-hydroxy-tamoxifen; RAL, raloxifene; E2, 17β estradiol; LBD, lig
Estradiol enhances cell-associated paraoxonase 1 (PON1) activity in vitro without altering PON1 expression
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; LDL, low density lipoprotein; HDL, high density lipoprotein; DEPFMU, 7-diethyl-phospho-6,8-difluoro-4-methylumbelliferyl; 2HQ, 2-hydroxyquinoline; DMSO, dimethyl sulfoxide; E2, estradiol; ER, estrogen receptor; SERM, selective estrogen receptor modulator;
Glyceollin I enantiomers distinctly regulate ER-mediated gene expression
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; 4-OH-Tam, 4-hydroxytamoxifen; E2, 17β-estradiol; ER, estrogen receptor; ERE, estrogen responsive element; GLY, glyceollin; ICI 182,780, Fulvestrant; PgR, progesterone receptor; SERM, selective estrogen receptor modulator; 3ERT, human estrogen receptor-alp
Nuclear receptor coregulators as a new paradigm for therapeutic targeting
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; NR, nuclear hormone receptor; LBD, ligand binding domain; DBD, DNA binding domain; SERM, selective estrogen receptor modulator; SRC, steroid receptor coactivator; ACTR, activator for receptors; AIB1, amplified in breast cancer 1; TIF2, transcriptional int
Selectively targeting estrogen receptors for cancer treatment
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; ER, estrogen receptor; SERM, selective estrogen receptor modulator; SERD, selective estrogen receptor down-regulator; ERKO, estrogen receptor knockout; PPT, propyl pyrazole triol; DPN, diarylpropionitrile; ARKO, aromatase inhibitor knockout; AOM, azoxymet
Novel estrone mimetics with high 17β-HSD1 inhibitory activity
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; 17β-HSD1, 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2, 17β-hydroxysteroid dehydrogenase type 2; E1, estrone; E2, 17β-estradiol; ER, estrogen receptor; SERM, selective estrogen receptor modulator; GnRH, gonadotropin-releasing hormone; NADP(H), nicoti
Effects of raloxifene on cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; cGMP, cyclic guanosine monophosphate; ER, estrogen receptor; MLC, myosin light chain; NO, endothelin-derived relaxing factor, nitrous oxide; RLX, raloxifene; SAH, subarachnoid hemorrhage; SERM, selective estrogen receptor modulator; VDCC, voltage-dependen
Timing is everything: Order of administration of 5-aza 2′ deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; 3′UTR, 3′untranslated region; AZA, 5-aza 2′ deoxycytidine; ER, estrogen receptor; SERM, selective estrogen receptor modulator; TSA, trichostatin AEstrogen receptor; Tamoxifen; 5-aza-2′ deoxycytidine; Trichostatin A; Epigenetic; MDA-MB-231; HuR
Differential estradiol and selective estrogen receptor modulator (SERM) regulation of Keratin 13 gene expression and its underlying mechanism in breast cancer cells
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; ChIP, chromatin immunoprecipitation; E2, 17β-estradiol; ER, estrogen receptor; ERE, estrogen response element; KRT13, keratin 13; Ral, raloxifene; SERM, selective estrogen receptor modulator; Tam, tamoxifenEstrogen receptor; Estradiol; Tamoxifen; SERM; Ge
Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; MCAo, middle cerebral artery occlusion; ICI 182,780, {7α-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]estra-1,3,5-(10)-triene-3,17β-diol}; EAAs, excitatory amino acids; ER, estrogen receptor; SERM, selective estrogen receptor modulator; IsoP, isoprostane
Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death
Keywords: SERM، مدولاتور گیرنده استروژن انتخابی; Tam, tamoxifen; OHT, 4-hydroxytamoxifen; ER, estrogen receptor; ERK, extracellular signal-regulated kinase; EGF, epidermal growth factor; JNK, Jun N-terminal kinase; RNAi, RNA interference; SERM, selective estrogen receptor modulator; E2, 17β-estradiol; M