کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3092206 1190510 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of raloxifene on cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Effects of raloxifene on cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits
چکیده انگلیسی

BackgroundThe aim of this study was to investigate the ability of a SERM, RLX, to prevent vasospasm in a rabbit model of SAH.MethodsThirty-four New Zealand white rabbits were allocated into 3 groups randomly. Subarachnoid hemorrhage was induced by injecting autologous blood into the cisterna magna. The treatment groups were as follows: (1) sham operated (no SAH [n = 12]), (2) SAH only (n = 12), and (3) SAH plus RLX (n = 10). Basilar artery lumen areas and arterial wall thickness were measured to assess vasospams in all groups.ResultsThere was a statistically significant difference between the mean basilar artery cross-sectional areas and the mean arterial wall thickness measurements of the control and SAH-only groups (P < .05). The difference between the mean basilar artery cross-sectional areas and the mean arterial wall thickness measurements in the RLX-treated group was statistically significant (P < .05). The difference between the SAH group and the SAH + RLX group was also statistically significant (P < .05).ConclusionsThese findings demonstrate that RLX has marked vasodilatatory effect in an experimental model of SAH in rabbits. This observation may have clinical implications suggesting that this SERM drug could be used as possible anti-vasospastic agent in patients without major adverse effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Surgical Neurology - Volume 72, Issue 5, November 2009, Pages 490–494
نویسندگان
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