Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR)
Keywords: آسم شدید; Comorbidities; Inflammation; Phenotype; Severe asthma;
مقالات ISI آسم شدید (ترجمه نشده)
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Low-level laser therapy suppresses the oxidative stress-induced glucocorticoids resistance in U937 cells: Relevance to cytokine secretion and histone deacetylase in alveolar macrophages
Keywords: آسم شدید; Severe asthma; Alveolar macrophages; Oxidative stress; Glucocorticoid resistance; Cytokines; Histone deacetylase
Phenotype properties and status of corticosteroid resistance among patients with uncontrolled asthma
Keywords: آسم شدید; Glucocorticoid lymphocyte proliferation suppression test; Glucocorticoid resistance; Severe asthma; Asthma phenotype; Uncontrolled asthma
Peripheral lung function in patients with stable and unstable asthma
Keywords: آسم شدید; Severe asthma; acinar airways; peripheral gas mixingACQ, Asthma Control Questionnaire; FRC, Functional residual capacity; FVC, Forced vital capacity; GINA, Global Initiative for Asthma; MBW, Multiple-breath nitrogen washout; Sacin, Acinar ventilation hete
Vitamin D deficiency and severe asthma
Keywords: آسم شدید; Vitamin D; Severe asthma; Exacerbation; Airway remodeling; Steroid resistanceADAM33, ADAM metallopeptidase domain 33; ASM, airway smooth muscle; CRTAM, class I major histocompatibility complex-restricted T cell-associated molecule; CXCL12, chemokine (C-X-
Bronchial Thermoplasty
Keywords: آسم شدید; Bronchial thermoplasty; Severe asthma; Airway remodeling; Airway smooth muscle;
Asthme sévère : les exacerbateurs viro-induits
Keywords: آسم شدید; Asthme; Asthme sévère; Enfant; VirusAsthma; Severe asthma; Child; Virus
Long-term omalizumab treatment in severe allergic asthma: The South-Eastern Mediterranean “real-life” experience
Keywords: آسم شدید; Asthma; Immunoglobulin E; Anti-IgE; Allergy; Severe asthma; Therapy; EfficacyΔFEV1, The difference of Forced expiratory volume in 1 s (FEV1) between time points; ΔFVC, The difference of Forced vital capacity (FVC) between time points; ACT, Asthma control
Increased corticosteroid sensitivity by a long acting β2 agonist formoterol via β2 adrenoceptor independent protein phosphatase 2A activation
Keywords: آسم شدید; Steroid insensitivity; Severe asthma; Formoterol; Glucocorticoid receptor; Phosphatase; Phosphorylation; Receptor-indepedentcAMP, 3′-5′-cyclic adenosine monophosphate; ERK, extra-cellular signal-regulated kinase; GR, glucocorticoid receptor; JNK, c-Jun N-
The IL6R variation Asp358Ala is a potential modifier of lung function in subjects with asthma
Keywords: آسم شدید; Soluble IL-6 receptor; IL-6; asthma; pulmonary lung function; severe asthma; IL-6 transsignaling; genetic variation; single nucleotide polymorphism rs2228145; ATS; American Thoracic Society; BAL; Bronchoalveolar lavage; CSGA; Collaborative Study on the Ge
Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma
Keywords: آسم شدید; Severe asthma; CD8+ T cells; transcriptome; long noncoding RNA; microRNAFDR, False discovery rate; LCN, Lipocalin 2; lncRNA, Long noncoding RNA; miRNA, MicroRNA; qRT-PCR, Quantitative RT-PCR; Treg, Regulatory T
Clinical characteristics and possible phenotypes of an adult severe asthma population
Keywords: آسم شدید; Asthma; Severe asthma; Characteristics; Atopy; Sputum eosinophils; Phenotypes;
Severe Asthma in Adults
Keywords: آسم شدید; Severe asthma; Rare disease; Orphan act; Phenotypes; Treatment-response;
Controverse : l’asthme sévère est allergique
Keywords: آسم شدید; IgE; Asthme sévère; Exacerbation; Allergie; Th2IgE; Severe asthma; Exacerbation; Allergy; Th2
Asma de control difÃcil: factores predisponentes y factores agravantes
Keywords: آسم شدید; Asma de control difÃcil; Asma refractaria; Asma resistente al tratamiento; Asma resistente a glucocorticoides; Asma corticodependiente; Asma difÃcil; Asma grave; Difficult-to-control asthma; Refractory asthma; Treatment-resistant asthma; Glucocorticoid-
Translocación nuclear del receptor de glucocorticoides en fibroblastos de pacientes asmáticos con poliposis nasal insensible al tratamiento glucocorticoideo
Keywords: آسم شدید; Asma grave; Poliposis nasal; Receptor de glucocorticoide; Severe asthma; Nasal polyposis; Glucocorticoid receptor;
Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)–like 2
Keywords: آسم شدید; Severe asthma; oxidative stress; inflammation; glutathione; cysteine; nuclear factor (erythroid-derived 2)–like 2 (Nrf2)ARE, Antioxidant response element; BAL, Bronchoalveolar lavage; COPD, Chronic obstructive pulmonary disease; CT, Cycle threshold; Eh, R
Vaccination of patients with mild and severe asthma with a 2009 pandemic H1N1 influenza virus vaccine
Keywords: آسم شدید; H1N1; asthma; influenza; vaccine; seroprotection; severe asthma; FVC; Forced vital capacity; GMT; Geometric mean titer; HAI; Hemagglutination inhibition; ICS; Inhaled corticosteroid; SAE; Serious adverse event; TIV; Trivalent seasonal influenza vaccine;
Safety of investigative bronchoscopy in the Severe Asthma Research Program
Keywords: آسم شدید; Investigative bronchoscopy; safety; severe asthma; exacerbation; ATS; American Thoracic Society; BAL; Bronchoalveolar lavage; BMI; Body mass index; DSMB; Data safety monitoring board; ED; Emergency department; HCU; Health care utilization; MoP; Severe Ast
Heterogeneity of severe asthma in childhood: Confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
Keywords: آسم شدید; Allergic sensitization; asthma; severe asthma; asthma guidelines; children; cluster analysis; lung function; phenotype; ATS; American Thoracic Society; GINA; Global Initiative for Asthma; ICS; Inhaled corticosteroid; LABA; Long-acting β-agonist; NAEPP; N
Italian real-life experience of omalizumab
Keywords: آسم شدید; Severe asthma; Omalizumab
Increased serum IL-17 is an independent risk factor for severe asthma
Keywords: آسم شدید; IL-17; Severe asthma; Risk factors
Racial differences in biologic predictors of severe asthma: Data from the Severe Asthma Research Program
Keywords: آسم شدید; Severe asthma; race; IgE; allergic sensitization; immunoinflammatory; BMI; Body mass index; FVC; Forced vital capacity; GERD; Gastroesophageal reflux disease; SARP; Severe Asthma Research Program; SES; Socioeconomic status;
Severe asthma and adherence to peak flow monitoring: Longitudinal assessment of psychological aspects
Keywords: آسم شدید; Adherence; Extraversion; Locus of control; Perceived control; Severe asthma; Social desirability;
Ciliary dysfunction and ultrastructural abnormalities are features of severe asthma
Keywords: آسم شدید; Ciliated epithelium; ciliary beat frequency; ciliary beat pattern; ciliary disorientation; ciliary dyskinesia; refractory asthma; severe asthma; FVC; Forced vital capacity; GINA; Global Initiative for Asthma; IQR; Interquartile range;
Recent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthma
Keywords: آسم شدید; Severe asthma; pediatric asthma; exacerbation; predictor of exacerbation; corticosteroid burst; long-term controlATAQ, Asthma Therapy Assessment Questionnaire; FSE, Future severe exacerbation; HCU, Health care use; NHLBI, National Heart, Lung, and Blood I
Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients
Keywords: آسم شدید; Monocyte subsets; CD14++CD16+ monocytes; CD14+CD16+ monocytes; Asthma; Severe asthma
“Real-life” effectiveness of omalizumab in patients with severe persistent allergic asthma: The PERSIST study
Keywords: آسم شدید; Asthma; Allergic asthma; Severe asthma; Omalizumab
Airway remodeling in subjects with severe asthma with or without chronic persistent airflow obstruction
Keywords: آسم شدید; Severe asthma; remodeling; airway smooth muscle; fibrosis; reticular basement membrane; inflammation; cytokines; high-resolution computed tomographic scan; biopsy; sputum; ASM; Airway smooth muscle; ATS; American Thoracic Society; CT; Computed tomography;
Leptin and leptin receptor expression in asthma
Keywords: آسم شدید; Leptin; leptin receptor; severe asthma; epithelium; TGF-β; remodeling; BECs; Bronchial epithelial cells from brushings; FP; Fluticasone propionate; C; Healthy control volunteer; ICS; Subject with mild asthma controlled with inhaled corticosteroids; NHBE;
Acetónido de triamcinolona en el tratamiento del asma resistente a los glucocorticoides: riesgos y beneficios
Keywords: آسم شدید; Asma grave; Asma corticorresistente; Prednisona; Acetónido de triamcinolona; Severe asthma; Corticosteroid-resistant asthma; Prednisone; Triamcinolone acetonide;
Efficacy/risk profile of triamcinolone acetonide in severe asthma: Lessons from one case study
Keywords: آسم شدید; Insulin; Refractory asthma; Severe asthma; Steroid-dependent asthma; Triamcinolone acetonide
Effectiveness of omalizumab (Xolair®) in the first patients treated in real-life practice in France
Keywords: آسم شدید; Severe asthma; Omalizumab; Anti IgE; Effectiveness; Treatment; Real life
Increased sputum and bronchial biopsy IL-13 expression in severe asthma
Keywords: آسم شدید; Severe asthma; IL-13; sputum; bronchus; airway smooth muscle; eosinophiliaACQ, Juniper Asthma Control Questionnaire; AHR, Airway hyperresponsiveness; ASM, Airway smooth muscle; GINA, Global Initiative for Asthma
Immunomodulatory and biologic therapies for severe refractory asthma
Keywords: آسم شدید; Severe asthma; Corticosteroids; Immunological modifiers; Steroid-sparing; Anti-TNFalpha drugs; Omalizumab
Difficult-to-Control Asthma in Adults
Keywords: آسم شدید; Misdiagnosis; Severe asthma; Refractory asthma;
Une cause exceptionnelle de tumeur trachéale : la tumeur fibreuse solitaire
Keywords: آسم شدید; Insuffisance respiratoire aiguë; Asthme sévère; Trachée; Tumeur fibreuse solitaire; Acute respiratory insufficiency; Severe asthma; Trachea; Solitary fibroma;
Advances in pediatric asthma 2006
Keywords: آسم شدید; Asthma; severe asthma; early intervention in asthma; biomarkers; therapeuticsBDR, Bronchodilator response; eNO, Exhaled nitric oxide; FVC, Forced vital capacity; ICS, Inhaled corticosteroid; LABA, Long-acting β2-adrenergic agonist; LT, Leukotriene; LTRA,
Monoclonal antibodies in Pediatrics: use in prevention and treatment
Keywords: آسم شدید; Monoclonal antibodies (MAbs); Hybridomas; Humanized MAbs; Murine MAbs; Autoimmune diseases; Allergic diseases; Neoplasms; RSV prophylaxis; Transplant rejection; Severe asthma; Anti-IgE MAbs;
Augmented epithelial endothelin-1 expression in refractory asthma
Keywords: آسم شدید; Endothelin-1; severe asthma; laser microdissection; fibrosis; airway smooth muscleASM, Airway smooth muscle; CCL2, Chemokine (C-C motif) ligand 2; CXCL8, Chemokine (C-X-C motif) ligand 8; ECM, Extracellular matrix; EDN1, Endothelin-1; MCP, Monocyte chemot
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Keywords: آسم شدید; Severe asthma; definition; bronchodilator response; pathophysiology; phenotype; pneumonia
Managing severe asthma
Keywords: آسم شدید; Corticosteroids; severe asthma; difficult to control asthma; refractory asthma; childhood asthma; adult asthma;
Immunopathologie de l'asthme sévère
Keywords: آسم شدید; Asthme sévère; Lymphocyte T; Expectoration induite; Severe asthma; Induced sputum; T lymphocytes;
Acute severe asthma presenting in late pregnancy
Keywords: آسم شدید; Severe asthma; Pregnancy
Utilidad clÃnica del omalizumab
Keywords: آسم شدید; Omalizumab; Terapia anti IgE; Asma grave persistente; Asma de control difÃcil; Rinitis alérgica; Omalizumab; Anti IgE therapy; Severe asthma; Difficult asthma; Allergic rhinitis;
Asma grave y resistente al tratamiento: conceptos y realidades
Keywords: آسم شدید; Asma de control difÃcil; Asma refractaria; Asma grave; Control del asma; Difficult to control asthma; Refractory asthma; Severe asthma; Asthma control;
Deficient alpha-1-antitrypsin phenotypes and persistent airflow limitation in severe asthma
Keywords: آسم شدید; Severe asthma; Persistent airflow limitation; Alpha-1-antitrypsin; Phenotype
Airway inflammation assessed by invasive and noninvasive means in severe asthma: Eosinophilic and noneosinophilic phenotypes
Keywords: آسم شدید; Severe asthma; bronchial biopsies; exhaled nitric oxide; induced sputumATS, American Thoracic Society; BrEos, Bronchial eosinophil; GR, Glucocorticoid receptor; MBP, Major basic protein; NO, Nitric oxide; spEosH, High sputum eosinophil count; spEosL, Low
Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma
Keywords: آسم شدید; Cofilin-1; peripheral blood T cells; glucocorticosteroids; severe asthma; Jurkat T cellsCR, Glucocorticoid-resistant; JNK, c-Jun N-terminal kinase; MA, Mild glucocorticoid-sensitive asthma; SIA, Severe glucocorticoid-insensitive asthma; UK, United Kingdom
Severe asthma: An overview
Keywords: آسم شدید; Severe asthma; definition; phenotype; eosinophils; sputum; exhaled nitric oxideATS, American Thoracic Society; ENFUMOSA, European Network for Understanding Mechanisms of Severe Asthma; EOS, Eosinophil; FeNO, Fraction of exhaled nitric oxide in ppb; GINA,