دانلود مقالات ISI درباره Shp-2 + ترجمه فارسی

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Atypical defects resulting in growth hormone insensitivity

Keywords: ALS; acid-labile subunit; CIS; cytokine-inducible SH2-containing protein; E2; estradiol; ER; endoplasmic reticulum; ERK; extracelular regulated kinase; ESPE; European Society for Pediatric Endocrinology; GH; growth hormone; GHBP; growth hormone binding pr

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

پروتئین کم پروتئین مولکولی تیروزین فسفاتاز: توابع چندوجهی یک آنزیم حفظ شده

Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme

Keywords: PTP; protein tyrosine phosphatase; PTK; protein tyrosine kinase; LMW-PTP; low molecular weight protein tyrosine phosphatase; LMW-AP; low molecular weight acid phosphatase; ACP1; gene coding for human LMW-PTP; PTP1B; tyrosine-protein phosphatase non-recept

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

محصولات طبیعی با فعالیت مهار کننده پروتئین تیروزین فسفاتاز

Natural products with protein tyrosine phosphatase inhibitory activity

Keywords: Protein tyrosine phosphatase; PTP1B; CD45; CDC25; SHP-1; SHP-2; MPTP; LAR; VHR; Natural products;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

انتقال سیگنال اینترلوکین -6 و نقش آن در اختلالات متابولیکی لیپیدی کبدی

Interleukin-6 signal transduction and its role in hepatic lipid metabolic disorders

Keywords: Interleukin-6 (IL-6); Metabolic disease; IL-6; interleukin-6; MS; metabolic syndrome; ROS; reactive oxygen species; IFN; interferon; hIL-6; human interleukin-6; SHP-2; Src homology domain-containing protein tyrosine phosphatase-2; IR; insulin resistance;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Fine tuning subsets of CD4+ T cells by low-dosage of IL-2 and a new therapeutic strategy for autoimmune diseases

Keywords: aa; Amino acids; A region; Acidic region of IL-2Rβ; AKT; Protein kinase B; AA; Alopecia Areata; CTLA-4; Cytotoxic T lymphocyte antigen-4; cDNA; Complementary DNA; Foxp3; Forkhead box P3; GVHD; Chronic graft-versus-host disease; HCV; Hepatitis C virus; hd

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells

Keywords: MeHg; methylmercury; Ca2+; Calcium; Rac1; ras related C3 botulinum toxin substrate 1; Cdc42; cell division control protein 42 homolog; RhoA; ras homolog gene family member A; GD; gestation day; PND; postnatal day; FAK; focal adhesion kinase; p-FAKY397; FA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Neutrophil CD16b crosslinking induces lipid raft-mediated activation of SHP-2 and affects cytokine expression and retarded neutrophil apoptosis

Keywords: Neutrophil; CD16b; CD32a; Shp-2;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

A change in structural integrity of c-Kit mutant D816V causes constitutive signaling

Keywords: JAK; Janus kinase; JM region; juxtamembrane region; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; MD; molecular dynamics; MIHC; Myb-immortalized haemopoietic cells; WT; wild-type c-Kit; WTp; wild-type phosphorylated c-Kit; MT_D816V

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis

Keywords: Interleukin 17; Fibroblast-like synoviocytes; Rheumatoid arthritis; SHP-2; STAT-3; Osteoclast;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Protein tyrosine phosphatase 1B inhibitors as antidiabetic agents - A brief review

Keywords: CD45; cluster of differentiation 45; CDC25; cell division cycle 25; DFMP; difluoromethylene phosphonates; IDDM; insulin-dependent diabetes mellitus; IGT; impaired glucose tolerance; JAK2; Janus Kinase 2; IBA; imbricatolic acid; MA; maslinic acid; MAP; mit

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1

Keywords: STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Study of SHP-2 (PTPN11) allosterism on structural movement using solution perturbed molecular dynamics simulation

Keywords: SPMD; SHP-2; Selectivity; Molecular dynamics; Solution interrupted system;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

S-nitrosylation of endogenous protein tyrosine phosphatases in endothelial insulin signaling

Keywords: ACN; acetonitrile; APIAM; N-(4-acetylphenyl)-2-iodoacetamide; BiFC; Bimolecular Fluorescence Complementation; BSA; bovine serum albumin; Cys; cysteine; DAPI; (4′,6-diamidino-2-phenylindole); DPIAM; N-(2,3-dimethylphenyl)-2-iodoacetamide; DMEM; Dulbecco'

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Could caveolae be acting as warnings of mitochondrial ageing?

Keywords: ERK; extracellular signal-regulated kinases; FAK; focal adhesion kinase; Nrf2; nuclear erythroid 2 p45-related factor-2; Shp-2; SH2 domain-containing phosphatase-2; CSK; c-Src tyrosine kinase; HO-1; hemeoxigenase 1; HIF1; hypoxia induced factor 1; SHP-2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease

Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3′,5′-cyclic adenosine monophosphate;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Influence of vitamin C and vitamin E on redox signaling: Implications for exercise adaptations

Keywords: 5-LOX; 5-lipoxygenase; AP-1; activating protein 1; cGMP; cyclic guanosine monophosphate; ERK; extracellular signal-regulated kinase; GSH; glutathione (reduced); GSSG; glutathione (oxidized); H2O2; hydrogen peroxide; HIF-α; hypoxia inducible factor alpha;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2015 سفارش ترجمه

Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer

Keywords: Colon cancer; SHP-2; Expression

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewRegulation of bone and skeletal development by the SHP-2 protein tyrosine phosphatase

Keywords: Ras signaling; SHP-2; skeletal deformity; scoliosis; metachondromatosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Modulation in the expression of SHP-1, SHP-2 and PTP1B due to the inhibition of MAPKs, cAMP and neutrophils early on in the development of cerulein-induced acute pancreatitis in rats

Keywords: Experimental acute pancreatitis; SHP-1; SHP-2; PTP1B; MAPK inhibition; Infiltration inhibition;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in can

Keywords: luteolin; 3′,4′,5,7-tetrahydroxyflavone; IFN; interferon; JAK; Janus kinase; STAT; signal transducer and activator of transcription; ISRE; interferon α-stimulated response element; PDE; phosphodiesterase; cAMP; cyclic adenosine 3′,5′-monophosphat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets

Keywords: LSECtin; liver and lymph node sinusoidal endothelial cell lectin; Th1; T helper type 1; Th2; T helper type 2; Th17; T helper type 17; GRAIL; gene related to anergy in lymphocyte; TCR; T cell receptor; Cbl-b; Casitas B-lineage lymphoma B; Itch; itchy homol

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response

Keywords: Enteropathogenic Escherichia coli; Tir; SHP-2; ITIM; TRAF6; Immune response;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

Keywords: dFCS; dialyzed fetal calf serum; GO; Gene Ontology; IPI; International Protein Index; LTQ; linear trap quadrupole; SILAC; stable isotope labeling by amino acids in cell culture; Arg6; l-arginine-13C6,14N4; Arg10; l-arginine-13C6,15N4; Lys4; l-lysine-2H4;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases

Keywords: Copper complexes; Protein tyrosine phosphatases; Selective inhibitor; Schiff base; CSD; Cambridge Structural Database; ESI-MS; electrospray ionization mass spectra; Hcpmp; 4-chloro-2-((phenylimino)methyl)phenol; Hnpmp; 4-bromo-2-((phenylimino)methyl)pheno

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2013 سفارش ترجمه

Mutational analysis of the PTPN11 gene in Egyptian patients with Noonan syndrome

Keywords: Egyptian patients; mutational analysis; Noonan syndrome; PTPN11; SHP-2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Short communicationDicer-dependent miRNAs provide an endogenous restraint on cytotrophoblast proliferation

Keywords: miRNA; IGF; ERK; SHP-2; siRNA;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Concanavalin A: A potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics

Keywords: BHA; butylated hydroxyanisole; BNIP3; adenovirus E1B 19 kDa-interacting protein 3; ConA; Concanavalin A; COX-2; cyclooxygenase-2; Cyto c; cytochrome c; DAPK; dual-specificity protein kinase; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activ

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Expansion of European vacA and cagA alleles to East-Asian Helicobacter pylori strains in Cambodia

Keywords: cag PAI; cag pathogenicity island; EPIYA; Glu-Pro-Ile-Tyr-Ala; GC; Gastric carcinoma; SH2; cytoplasmic Src homology 2; SHP-2; Src homology 2 phosphatase; NFAT; nuclear factor of activated T cells; H. pylori; cagA; vacA; Recombination; Genetic population;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Oxidative stress, insulin signaling, and diabetes

Keywords: AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch

Keywords: CFSE; 5,6-carboxyfluorescein diacetate succinimidyl ester; CTLA-4; cytotoxic T lymphocyte antigen-4; PKC-Θ; protein kinase C Θ; PLC-γ1; phospholipase C-γ1; SHP-2; SH2-domain containing protein tyrosine phosphatase 2; Costimulation; Signal transduction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration

Keywords: SHP-2, Src homology 2 domain-containing protein tyrosine phosphatase 2; Cas-L, Crk-associated substrate lymphocyte typeCas-L; SHP-2; Focal adhesion; Tyrosine phosphorylation; Cell migration

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Programmed death-1 receptor negatively regulates LPS-mediated IL-12 production and differentiation of murine macrophage RAW264.7 cells

Keywords: PD-1; IL-12; SHP-2; JNK phosphorylation; Endocytic activity; Macrophages;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

The tyrosine phosphatase SHP-2 controls urokinase-dependent signaling and functions in human vascular smooth muscle cells

Keywords: SHP-2; Urokinase; Vascular smooth muscle cell; Signal transduction; Lipid rafts

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Somatostatin/somatostatin receptor signalling: Phosphotyrosine phosphatases

Keywords: Somatostatin; Somatostatin receptors; Phosphotyrosine phosphatase; Cell proliferation; Apoptosis; MAP kinase; SHP-1; SHP-2; DEP-1/PTPη

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats

Keywords: SHP-1; SHP-2; Acute pancreatitis; Cerulein; SP600125; Rolipram

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

PECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells

Keywords: CD31; Alternative splicing; Signal transduction; Cell migration; Cell adhesion; MAPK/ERKs; SHP-2; Src

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Mild variable Noonan syndrome in a family with a novel PTPN11 mutation

Keywords: Noonan syndrome; Short stature; PTPN11; SHP-2; Autosomal dominant

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

HER-2/neu raises SHP-2, stops IFN-γ anti-proliferation in bladder cancer

Keywords: HER-2/neu; IFN-γ; SHP-2; Jak/Stat; Cell growth

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women

Keywords: SHP-2; PI3-kinase; apoB; LDL-cholesterol; Metabolic syndrome; Genetic susceptibility

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor

Keywords: Jak2; SHP-2; Angiotensin II; Signal transduction; AT1 receptor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

SHP-2-Erk signaling regulates Concanavalin A-dependent production of TIMP-2

Keywords: SHP-2; TIMP-2; MAPK pathway; Concanavalin A; MMP-2; Signaling

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Granulocyte macrophage-colony stimulating factor reduces the affinity of SHP-2 for the ITIM of CLECSF6 in neutrophils: A new mechanism of action for SHP-2

Keywords: CLECSF6; DCIR; ITIM; Neutrophil; Phosphatase; SHP-1; SHP-2; SHIP-1; Inflammation; Signal transduction; Detergent; GM-CSF; Tyrosine phosphorylation; Peptide

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation

Keywords: Ionizing radiation; EGFR; Src; Transactivation; ERK; SHP-2; PP2; AG1478

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2006 سفارش ترجمه

Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia

Keywords: SHP-2; PTPN11; RAS signaling; MDS; CMML;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2005 سفارش ترجمه

In silico identification of the key components and steps in IFN-γ induced JAK-STAT signaling pathway

Keywords: IFN-γ; interferon gamma; JAK; Janus kinase; STAT; signal transducers and activators of transcription; IFNR; interferon-γ receptor; RJ; IFNR-JAK complex; STAT1; signal transducer and activator of transcription 1; SHP-2; SH2 domain-containing tyrosine p

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Aging alters vascular mechanotransduction: Pressure-induced regulation of p70S6k in the rat aorta

Keywords: Aorta; p70S6k; GSK-3β; PTEN; SHP-2; Mechanotransduction; Aging;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

A SHPing tale: Perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail

Keywords: SHP-1; SHP-2; Phosphatase; C-terminus; Phosphorylation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Lipoxin A4 inhibits TNF-α-induced production of interleukins and proliferation of rat mesangial cells

Keywords: lipoxin; tumor necrosis factor; interleukin; nuclear factor-kappa B; SHP-2; cyclin; Akt; p27; STAT; mesangial cells;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Germ-line and somatic PTPN11 mutations in human disease

Keywords: PTPN11; SHP-2; Noonan syndrome; LEOPARD syndrome; Juvenile myelomonocytic leukemia; Acute leukemia; Myelodysplastic syndromes; Gain-of-function mutations; Genotype-phenotype correlation;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه