دانلود مقالات ISI درباره Shp2 + ترجمه فارسی

اسیدهای چرب آزاد امگا 3 موجب تضعیف سلول های سرطانی سرطان پستان شده توسط انسولین می شوند

Omega-3 free fatty acids attenuate insulin-promoted breast cancer cell proliferation

Keywords: Breast cancer; Insulin; Omega-3 free fatty acids; Insulin signal pathway; shp2; ALA; α-linolenic acid; ANOVA; analysis of variance; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; FFA; free fatty acid; TBST; Tris-buffered saline with Tween 20;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

بینش ساختاری و عملکردی جدید در تنظیم رأس

New structural and functional insight into the regulation of Ras

Keywords: Ras; Y32; Src; Shp2; GTPase cycle;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

نقش لپتین در تنظیم متابولیسم استخوان

The role of leptin in regulating bone metabolism

Keywords: BMI; body mass index; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; CART; cocaine- and amphetamine-related transcript; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal trans

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

تنظیم فسفاتاز فعال سازی ماکروفاژ

Phosphatase regulation of macrophage activation

Keywords: Macrophage activation; Lipid phosphatase; SHIP; PTEN; Protein tyrosine phosphatase; Shp2; PTPN22; PTP1B; SHP-1; Protein phosphatase; MKP-1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

چشم انداز: تریستروز فسفاتاز به عنوان اهداف جدید برای درمان آنتی بادی تلقی می شود

Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy

Keywords: Protein tyrosine phosphatases; PTP; Inhibitor; Thrombosis; Antithrombotic; Platelets; Antiplatelet; Therapy; Drug; GPVI; CLEC-2; DUSP3; VHR; CD148; PTP1B; SHP1; SHP2;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

فیزیولوژی لپتین: هوموتاز انرژی، عملکرد نوروآندوکرین و متابولیسم

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism

Keywords: ACC; acetyl-CoA carboxylase; AgRP; agouti-related peptide; AMPK; AMP-activated protein kinase; ARC; arcuate nucleus; BAT; brown adipose tissue; CART; cocaine- and amphetamine-regulated transcript; CCK; cholecystokinin; CNS; central nervous system; FGF; fi

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2015 سفارش ترجمه

لپتین و مغز: تأثیرات بر رشد مغز، عملکرد شناختی و اختلالات روانی

Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders

Keywords: BBB; blood brain barrier; ARC; arcuate nucleus of hypothalamus; NPY; neuropeptide Y; AgRP; agouti-related peptide; POMC; pro-opiomelanocortin; αMSH; α-melanocyte stimulating hormone; LepRb; leptin receptor; JAK2; janus kinase 2; STAT3; signal transducer

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2015 سفارش ترجمه

استرس بیسولفید: نوع جدیدی از استرس اکسیداتیو در پانکراتیت حاد است

Disulfide stress: a novel type of oxidative stress in acute pancreatitis

Keywords: AP1; activator protein 1; APE1; apurinic/apyrimidinase endonuclease 1; BIAM; biotinylated iodoacetamide; GSH; reduced glutathione; GSSG; oxidized glutathione; ho-1; heme oxygenase-1; IAM; iodoacetamide; Keap1; Kelch-like ECH-associated protein 1; MBrB; mo

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression

Keywords: microRNA; OSCC; SHP2; EGFR; Proliferation; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

The physiopathologic interplay between stem cells and tissue niche in muscle regeneration and the role of IL-6 on muscle homeostasis and diseases

Keywords: IL-; interleukin; SC; satellite cell; ECM; extracellular matrix; MuSCs; muscle stem cells; ROS; reactive oxygen species; Treg; regulatory T cells; Pax7; Paired box protein 7; Myf5; myogenic factor 5; MyoD; myoblast determination protein; MRF; muscle regul

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Tumorigenic role of YAP in hepatocellular carcinogenesis is involved in SHP2 whose function is different in vitro and in vivo

Keywords: YAP; Yes, associated protein; SHP2; Src homology phosphotyrosine phosphatase 2; HCC; hepatocellular carcinoma; TMA; tissue microarray; RFS; recurrence-free survival; OS; overall survival; SD; standard deviation; W; whole cell lysates; N; nuclear lysates;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Targeting phosphatases of regenerating liver (PRLs) in cancer

Keywords: Protein tyrosine phosphatase; Metastasis; Theinopyridone; Structure; CBS; cystathionine-beta-synthase; CHO; Chinese hamster ovary; CNNM; magnesium transporters of cyclin M; EMT; epithelial-mesenchymal transition; HMVEC; human microvascular endothelial c

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Spinal SHP2 Contributes to Exaggerated Incisional Pain in Adult Rats Subjected to Neonatal and Adult Incisions via PI3K

Keywords: AMPA receptor; α-amino-3-hydroxy-5-methy-4-isoxazole propionate receptor; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DRG; dorsal root ganglion; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ethe

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2018 سفارش ترجمه

Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma

Keywords: Thyroid carcinoma; SHP2; Hook1; Immunochemistry; Prognosis;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctions

Keywords: Cholesterol crystals; Adherens junctions; H2O2; SHP2; Vascular permeability;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Increased GPNMB, phospho-ERK1/2, and MMP-9 in cystic fibrosis in association with reduced arylsulfatase B

Keywords: N-acetylgalactosamine-4-sulfatase; Glycosaminoglycans; Sulfatase; β-1 integrin; ARSB; arylsulfatase B N-acetylgalactosamine-4-sulfatase; BEC; bronchial epithelial cells; C4S; chondroitin 4-sulfate; CF; cystic fibrosis; CFTR; cystic fibrosis transmembrane

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

A shift in the IL-6/STAT3 signalling pathway imbalance towards the SHP2 pathway in severe asthma results in reduced proliferation process

Keywords: IL-6; interleukin 6; STAT3; signal transducer and activator of transcription 3; SHP2; Src-homology 2 domain-containing phosphatase 2; MAPK; mitogen-activated protein kinase; NBF; normal bronchial fibroblasts; MABF; mild asthmatic bronchial fibroblasts; SA

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic β-Catenin, PIK3CA and MET

Keywords: Liver tumorigenesis; Shp2; Met; β-Catenin; PIK3CA;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics

Keywords: SPB; structure based pharmacophore; ADMET; absorption, distribution, metabolism, excretion, and toxicity; TCPTP; T cell protein-tyrosinephosphatase; PTP1B; protein tyrosine phosphatase 1B; NS; Noonan Syndrome; JMML; juvenile myelomonocytic leukemia; AML;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors

Keywords: Benzo[c][1,2,5]thiadiazole derivatives; PTP1B; SHP2; Inhibitors; Structure-activity relationships (SAR);

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2

Keywords: Drug discovery; Structural biology; Allosteric; Inhibitor; Phosphatase; SHP2;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Heterozygous deletion of AKT1 rescues cardiac contractility, but not hypertrophy, in a mouse model of Noonan Syndrome with Multiple Lentigines

Keywords: SHP2; AKT; Cardiac hypertrophy; Cardiomyopathy; Phosphatase; Signal transduction;  +;  transgenic; AKT; protein kinase B; HCM; hypertrophic cardiomyopathy; LV; left ventricle; LVAWd; LV anterior wall thickness at end-diastole; LVIDd; LV inner diameter a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Gln223Arg polymorphism in the Caucasian population and Pro1019Pro polymorphism in the Chinese population are risk factors for OSAS: An updated meta-analysis of 1159 subjects

Keywords: ACC; acetyl-CoA carboxylase; AMPK; 5′ adenosine monophosphate-activated protein kinase; CI; confidence intervals; CNKI; Chinese National Knowledge Infrastructure; Grb2; growth factor receptor-bound protein 2; HWE; Hardy-Weinberg equilibrium; IRS; insu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The good and the bad faces of STAT1 in solid tumours

Keywords: BAD; Bcl2-associated agonist of cell death; Bcl; B-cell lymphoma; CD; cluster of differentiation; CDK; cyclin-dependent kinase; CTL; cytotoxic T lymphocyte; CUG; cancer upregulated gene; CXCL; C-X-C motive ligand; DC; dendritic cells; DAMP; danger-associa

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617F-positive cells and mediates proliferation of human erythroleukaemia cells

Keywords: AEBSF; 4-(2-aminoethyl)-benzolsulfonylfluorid; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; Epo; erythropoietin; EpoR; erythropoietin receptor; Erk; extracellular signal regulated kinase; FCS; fetal calf serum; Gab1; G

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Acute lymphoblastic leukemia in the context of RASopathies

Keywords: RASopathies; Noonan syndrome; Acute lymphoblastic leukemia; PTPN11; SHP2; SOS1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

Keywords: SHP2/PTPN11; LEOPARD syndrome; Noonan syndrome; Protein tyrosine phosphatase; Parafibromin/CDC73; Wnt signal; SHP2; Src homology 2 domain-containing protein tyrosine phosphatase 2; PTP; Protein tyrosine phosphatase; NS; Noonan syndrome; LS; LEOPARD syndro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewThe regulation of male fertility by the PTPN11 tyrosine phosphatase

Keywords: PTPN11; protein-tyrosine phosphatase non-receptor type 11; SHP2; SH2-containing tyrosine phosphatase 2; SSC; spermatogonial stem cell; ACSL4; acyl-CoA synthetase; GDNF; glial cell-derived neurotrophic factor; bFGF; basic fibroblast growth factor; BTB; blo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

MKP-3 regulates PDGF-BB effects and MAPK activation in meningioma cells

Keywords: MEK 1/2; MKP-3; Leptomeninges; Meningioma; Phosphatases; p44/42 MAPK; SHP2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and biological evaluation of open-chain analogs of cyclic peptides as inhibitors of cellular Shp2 activity

Keywords: Chain peptides; Synthesis; SHP2; Inhibitory activity; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ

Keywords: PTEN; IFN-γ; ROS; SHP2; Signaling;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling

Keywords: Cervical cancers;; Resveratrol;; SHP2;; PIAS3;; SOCS3;; STAT3 signaling pathway;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Systems biology of IL-6, IL-12 family cytokines

Keywords: Systems biology; Mathematical modeling; IL-6-type cytokines; Quantitative analyses; Epo; erythropoietin; gp; glycoprotein; hESC; human embryonic stem cells; EGF; epidermal growth factor; ERK; extracellular signal regulated kinase; HGF; hepatocyte growth f

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The role of the protein tyrosine phosphatase SHP2 in cardiac development and disease

Keywords: PTPN11; SHP2; Phosphatase; Cardiac development; Congenital heart disease; Myocardium

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticlePTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients

Keywords: HCC; hepatocellular carcinoma; Shp2; Src-homology 2 domain-containing phosphatase 2; DFS; disease free survival; OS; overall survival; PI3-K; phosphoinositide 3-kinase; Akt; v-akt murine thymoma viraloncogene homolog; Hepatocellular carcinoma; Shp2; Metas

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Xenopus laevis FGF receptor substrate 3 (XFrs3) is important for eye development and mediates Pax6 expression in lens placode through its Shp2-binding sites

Keywords: FGF; Frs3; Xenopus; Shp2; Eye development; Pax6; Lens placode;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Leukemia inhibitory factor (LIF)

Keywords: Leukemia inhibitory factor; JAK/STAT/SOCS; LIF receptor; Embryonic stem cells; Pregnancy; Nerve and muscle; LIF; leukemia inhibitory factor; CNTF; ciliary neurotrophic growth factor; CT1; cardiotrophin 1; CLC; carditrophin-like cytokine; JAK; Janus kinase

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch

Keywords: Crk; CT10 regulator of kinase; CRKL; Crk-like protein; ERK; extracellular signal regulated kinase; FCS; foetal calf serum; Gab1; Grb2-associated binder 1; Grb2; growth factor receptor bound protein 2; IL-6; interleukin-6; JAK; Janus kinase; HEK; human emb

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

SHP2 sails from physiology to pathology

Keywords: Noonan syndrome; Noonan syndrome with multiple lentigines; PTPN11; Shp2; Signaling; Functional genetics

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Keywords: GSH; Glutathione; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; IR; Insulin receptor; MR; Methionine restriction; mTORC1; Mechanistic target of rapamycin complex 1; NAFLD; Non-alcoholic fatty liver disease; p70S6K; p70 ribosomal S6 kinase; PIP3; P

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

BDNF contributes to the development of neuropathic pain by induction of spinal long-term potentiation via SHP2 associated GluN2B-containing NMDA receptors activation in rats with spinal nerve ligation

Keywords: ACC; the anterior cingulate cortex; AMPAR; a-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptor; ANOVA; analysis of variance; AUC; area under the time-course curve; BDNF; brain-derived neurotrophic factor; CREB; cAMP response element-binding p

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2015 سفارش ترجمه

NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation

Keywords: 2-OH-E+; 2-hydroxyethidium; BAEC; bovine aortic endothelial cell; BSA; bovine serum albumin; cGMP; cyclic guanosine monophosphate; cSrc; proto-oncogene tyrosine protein kinase Src; DHE; dihydroethidine; EDHF; endothelial-derived hyperpolarizing factor; eN

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2015 سفارش ترجمه

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V

Keywords: PDGFRA; PTPN11; SHP2; STAT5; Chronic eosinophilic leukemia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FLT3; Fms-like tyrosine kinase 3; FPα; FIP1L1-PDGFRα; GIST; gastrointestinal stromal tumors; MAPK; mitogen-activated protein

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; AMPK; AMP-activated protein kinase; ELISA; enzyme-linked immunosorbent assay; GTT; glucose tolerance test; GP130; glycoprotein 130; HP; haptoglobin; HRP; horseradish peroxidase; IL-6; interleukin-6; IL6Rα;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma

Keywords: SHP2; Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2; ERK; extracellular signal-regulated protein kinase; PTP; protein tyrosine phosphatase; EGFR; epidermal growth factor receptor; SHP2; EGFR; Lung cancer; Drug resistance; Phosphata

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels

Keywords: Apo; apolipoprotein; BAC; bacterial artificial chromosome; BSA; bovine serum albumin; DS; Down syndrome; DYRKs; dual-specificity tyrosine-(Y)-phosphorylation regulated kinases; ES; embryonic stem; HDL; high-density lipoprotein; HRP; horseradish peroxidase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

Keywords: dFCS; dialyzed fetal calf serum; GO; Gene Ontology; IPI; International Protein Index; LTQ; linear trap quadrupole; SILAC; stable isotope labeling by amino acids in cell culture; Arg6; l-arginine-13C6,14N4; Arg10; l-arginine-13C6,15N4; Lys4; l-lysine-2H4;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells

Keywords: Protein tyrosine phosphatases; Yeast; Cell-based assay; TCPTP; Shp2; PEST; PTPα

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Enhanced anti-melanoma efficacy of interferon alfa-2b via inhibition of Shp2

Keywords: Shp2; STAT1; Melanoma; Interferon

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Helicobacter pylori stimulates epithelial cell migration via CagA-mediated perturbation of host cell signaling

Keywords: Helicobacter pylori; CagA; Cell motility; SHP2; PAR1/MARK

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه