Interleukin-6 signalling: More than Jaks and STATs
Keywords: Interleukin-6; MAPK; PI3K; Gab; gp130; SHP2; IL-6;
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Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks
Keywords: Abl; Abelson tyrosine-protein kinase 1; ADAP1; arf-GAP with dual PH domain-containing protein 1; AFM; atomic force microscopy; cAMP; cyclic adenosine monophosphate; ApoER2; apolipoprotein E receptor 2; BCAR1; breast cancer anti-estrogen resistance 1; p130
Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats
Keywords: Spinal nerve ligation; SIRPα1; SHP2; PSD-95; NMDA; NR2B; NSC-87877;
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K
Keywords: Juvenile myelomonocytic leukemia; PTPN11; KSR1; GM-CSF hypersensitivity; Shp2;
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs
Keywords: Shp2; Protein tyrosine phosphatase; Estramustine phosphate; Enoxolone; Celastrol; Triterpenoids
Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB
Keywords: Glucocorticoid; BDNF; TrkB; ERK; Shp2; Synaptic plasticity;
Shp2 suppresses PyMT-induced transformation in mouse fibroblasts by inhibiting Stat3 activity
Keywords: Polyoma middle T antigen; Transformation; Shp2; Oncogene; Signal transduction; Fibroblasts
Tyrosine phosphatases as key regulators of StAR induction and cholesterol transport: SHP2 as a potential tyrosine phosphatase involved in steroid synthesis
Keywords: StAR; steroidogenic acute regulatory protein; AA; arachidonic acid; Acsl4; acyl-CoA synthetase 4; Acot2; acyl-CoA thioesterase 2; PTP; protein tyrosine phosphatase; ACTH; adrenocorticotropin; LH; luteinizing hormone; cAMP; cyclic adenosine monophosphate;
Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay
Keywords: SHP2; Activity-based probe; Chemical probe; Protein tyrosine phosphatase;
SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells
Keywords: ZAP70; SHP2; ERK1/2; LIF receptor; Self-renewal
Nrg1/ErbB signaling networks in Schwann cell development and myelination
Keywords: Neuregulin; Shp2; Erk; Erbin; Myelination
The phosphatase Shp2 is required for signaling by the Kaposi's sarcoma-associated herpesvirus viral GPCR in primary endothelial cells
Keywords: Kaposi's sarcoma; KSHV; vGPCR; G protein-coupled receptor; Shp2; Protein tyrosine phosphatase; angiogenesis
Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function
Keywords: Tyrosine kinase; Intracellular signalling; FRS2; Shp2; FLIM; Cancer;
Cross-talk between adipose and gastric leptins for the control of food intake and energy metabolism
Keywords: ACTH; adrenocorticotropic hormone; ADIPOR1/2; adiponectin receptor1/2; AgRP; agouti related protein; AMPK; AMP-activated protein kinase; BSDL; bile salt-dependent lipase; cAMP; cyclic adenosine-monophosphate; CART; cocaine amphetamine related transcript;
Protein tyrosine phosphatase SHP2 is involved in Semaphorin 4D-induced axon repulsion
Keywords: Semaphorin; Sema4D; Plexin; Plexin-B1; SHP2; Protein tyrosine phosphatase; NSC-87877
Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation
Keywords: Satellite cell; Myoblast; Proliferation; HGF; SHP2; Pax7
The epidermal growth factor receptor ligand amphiregulin is a negative regulator of hepatic acute-phase gene expression
Keywords: APR; acute-phase reaction; APP; acute-phase protein; IL; interleukin; EGFR; epidermal growth factor receptor; AR; amphiregulin; OSM; oncostatin M; STAT; signal transducer and activator of transcription; TNF; tumour necrosis factor; JAK; Janus-activated ki
SHPS-1/SIRP1α contributes to interleukin-6 signalling
Keywords: IL-6; SIRP1α; SHPS-1; SHP2; Signal transduction
The molecular functions of Shp2 in the Ras/Mitogen-activated protein kinase (ERK1/2) pathway
Keywords: Shp2; Ras; ERK1/2; Gab1; Src; RasGAP; Sprouty; SHPS
A2 isoform of mammalian translation factor eEF1A displays increased tyrosine phosphorylation and ability to interact with different signalling molecules
Keywords: eEF1A1; eEF1A2; SH2 domain; SH3 domain; Shp2
Annexin II binds to SHP2 and this interaction is regulated by HSP70 levels
Keywords: SHP2; Annexin II; HSP70; Calcium chelators
SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent ICaL, [Ca2+]i transient, and APD increase in cardiomyocytes
Keywords: IL-6; Leukemia inhibitory factor (LIF); Ion channel; L-type Ca2+ current; Patch clamp; Fluo-4; SHP2
HSP70 binds to SHP2 and has effects on the SHP2-related EGFR/GAB1 signaling pathway
Keywords: SHP2; HSP70; EGF; EGFR; GAB1;
Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant
Keywords: SHP2; Phosphatase; EGFR; Substrate trapping
Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation
Keywords: Gastric cancer; Leptin; ERK2; STAT3; SHP2;
A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis
Keywords: Lung; Shp2; Branching morphogenesis; Erk phosphorylation; Smooth muscle cell;
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases
Keywords: SFK; Src-family protein tyrosine kinases; CSK; C-terminal Src kinase; CHK; CSK-homologous kinase; SH2 and SH3 domains; Src-homology 2 and Src-homology 3 domains; YT; C-terminal tail regulatory tyrosine of SFKs; YA; autophosphorylated tyrosine in the activ
The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling
Keywords: CLC; CT-1-like factor; CNTF; ciliary neurotrophic factor; CT-1; cardiotrophin-1; IL; interleukin; JAK; Janus kinase; LIF; leukaemia inhibitory factor; MAPK; mitogen-activated protein kinase; OSM; oncostatin M; PI3K; phosphatidylinositol-3-kinase; SHP; SH2
Signaling by Kit protein-tyrosine kinase-The stem cell factor receptor
Keywords: Akt; APS; Bad; Cancer; Cbl; Dok1; Erk; Fyn; Grb2; Grb7; Hematopoiesis; Leukemia cell lines; Lyn; MAP kinase; Mast cell; Oncogene; Piebaldism; Protein kinase; Protein phosphatase; Proto-oncogene; Ras; Shp1; Shp2; Src family kinase;
Src kinase regulation by phosphorylation and dephosphorylation
Keywords: Cancer; CD45; Epidermal growth factor receptor; ErbB/HER receptors; Integrin receptor; Non-receptor protein-tyrosine kinase; Oncogene; Platelet-derived growth factor receptor; Protein kinase; Protein phosphatase; Proto-oncogene; PTPα; PTPε; PTPλ; PTP-B
Right time, right place: the organization of membrane proximal signaling
Keywords: AP-1; activator protein 1; Bam32; B-lymphocyte adaptor molecule of 32Â kDa; BCR; B-cell receptor; Cbp; Csk binding protein; Csk; carboxyl-terminal Src kinase; DAG; diacylglycerol; DAPP1; dual adaptor for phosphotyrosine and 3-phosphoinositides; ERK; extra