Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB

► Glucocorticoid reduced the BDNF-increased synapse via inhibiting activation of ERK. ► BDNF-dependent interaction of Shp2 with TrkB was diminished by glucocorticoid. ► Glucocorticoid reduced BDNF-stimulated ERK via inhibiting the Shp2-TrkB interaction.