Selective inhibition of STAT1 reduces spinal cord injury in mice
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Spinal cord injury; STAT1; Small interfering RNA; Inflammation
مقالات ISI RNA های خاموشگر، آران‌ای خاموشگر (ترجمه نشده)
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Shikonin induces cell cycle arrest in human gastric cancer (AGS) by early growth response 1 (Egr1)-mediated p21 gene expression
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; CDK; cyclin dependent kinase; ChIP; chromatin immunoprecitiation; CKI; cyclin-dependent kinase; Egr1; early growth response 1; siRNA; small interfering RNA; Anti-proliferation; Cell cycle arrest; Egr1; p21; Shikonin;
RNA silencing targeting PIN (protein inhibitor of neuronal nitric oxide synthase) attenuates the development of hypertension in young spontaneously hypertensive rats
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Hypertension; neuronal nitric oxide synthase; nitric oxide; oxidative stress; protein inhibitor of nNOS; small interfering RNA
Recognizing the enemy within: licensing RNA-guided genome defense
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; transposon; genome defense; small RNA; RNAi; small interfering RNA; PIWI-interacting RNA
Quaternized starch-based carrier for siRNA delivery: From cellular uptake to gene silencing
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Quaternized starch; Polysaccharide; Small interfering RNA; Drug delivery; Self-assembly complexes
Research ArticleActivated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HSC; hepatic stellate cell; IFN; interferon; MDSC; myeloid derived suppressor cell; PGE2; prostaglandin E2; SCF; stem cell factor; siRNA; small interfering RNA; shRNA; small hairpin RNA; VEGF; vascular endothelial growth factor; Hepatic stellate cell; Mye
Immunopharmacology and information5â²-Triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HBV; hepatitis B virus; IFN; interferon; RIG-I; retinoic acid-inducible gene I; RNAi; RNA interference; siRNA; small interfering RNA; 3p-siRNA; 5â²-triphosphated siRNA; NC-siRNA; negative control siRNA; BF-siRNA; bifunctional siRNA; HCC; hepatocellular c
Liquid crystalline phase nanodispersions enable skin delivery of siRNA
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Nanodispersions; Liquid crystalline phase; Small interfering RNA; Topical delivery; Skin penetration
PSMA specific single chain antibody-mediated targeted knockdown of Notch1 inhibits human prostate cancer cell proliferation and tumor growth
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Single-chain antibody; Small interfering RNA; Prostate-specific membrane antigen; Notch1; Prostate cancer
Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Survivin; Small interfering RNA; Non-viral vector; Nanoparticles; Anti-tumor therapy
Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Porcine kidney autotransplantation; Ischemia–reperfusion injury; Caspase 3; Apoptosis; Inflammation
Effect of short hairpin RNA-induced CXCR4 silence on ovarian cancer cell
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; CXC chemokine receptor-4; SW626; Small interfering RNA; Ovarian cancer
Small interfering RNAs targeting the rabies virus nucleoprotein gene
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Rabies virus; Nucleoprotein gene;
Knockdown of the Epidermal Growth Factor Receptor Gene to Investigate Its Therapeutic Potential for the Treatment of Non–Small-Cell Lung Cancers
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Epidermal growth factor receptor; Epidermal growth factor receptor–tyrosine kinase inhibitors; Non–small-cell lung cancer; Oncogene addiction; Small interfering RNA
Small interfering RNA against the 2C genomic region of coxsackievirus B3 exerts potential antiviral effects in permissive HeLa cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Coxsackievirus B3; RNA interference; Small interfering RNA;
Research ArticleDiacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; DGK; diacylglycerol kinase; DG; diacylglycerol; PA; phosphatidic acid; siRNA; small interfering RNA; ERK; extracellular signal-regulated kinase; MEK; MAPK/ERK kinase; HGF; hepatocyte g
Adenovirus-vectored shRNAs targeted to the highly conserved regions of VP1 and 2B in tandem inhibits replication of foot-and-mouth disease virus both in vitro and in vivo
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Foot-and-mouth disease virus; Small interfering RNA; Adenovirus; VP1 gene; 2B gene
Research ArticleA functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HCV; hepatitis C virus; IFN-α; interferon-α; siRNA; small interfering RNA; SART1; squamous cell carcinoma antigen recognized by T cells; U4/U6.U5 tri-snRNP; U4/U6.U5 tri-small nuclear ribonucleoproteins; HCV; IFN-α; siRNA; SART1; U4/U6.U5tri-snRNP;
Research ArticleMicroRNA-135a contributes to the development of portal vein tumor thrombus by promoting metastasis in hepatocellular carcinoma
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HCC; hepatocellular carcinoma; PVTT; portal vein tumor thrombus; miR-135a; microRNA-135a; FOXM1; forkhead box M1; MTSS1; metastasis suppressor 1; PT; parenchyma tumor nodules tissue; UTR; untranslated region; siRNA; small interfering RNA; AS; antisense ol
Safety profile of RNAi nanomedicines
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Nanotoxicology; SNALP; Preclinical toxicology; Immunostimulation; Complement activation
Cationic star polymer siRNA transfectants interconnected with a piperazine-based cationic cross-linker
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Star polymers; Group transfer polymerization; Piperazine cross-linker; Gene transfer; siRNA delivery systems
The role of BCL11B in regulating the proliferation of human naive T cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; BCL11B gene; Naive T cells; Small interfering RNA; Gene expression profiling; T-cell proliferation
Facial amphipathic deoxycholic acid-modified polyethyleneimine for efficient MMP-2 siRNA delivery in vascular smooth muscle cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Facial amphiphilicity; Deoxycholic acid; Matrix metallo proteinase-2; Smooth muscle cell migration; Restenosis
Lipid nanoparticles for hepatic delivery of small interfering RNA
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Cationic lipids; Lipid nanoparticles; Small interfering RNA; Hepatocellular carcinoma
Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous Cell carcinoma-derived cancer stem cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; Head and neck squamous cell carcinoma; EZH2; Oct4; Nuclear localization signal
Research ArticleMybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HCC; hepatocellular carcinoma; DN; dysplastic nodule; FOXM1; Forkhead box M1B; CCNA2; Cyclin A2; TOPA2; topoisomerase II alpha; F344; Fisher 344; BN; Brown Norway; FBS; fetal bovine serum; siRNA; small interfering RNA; QRP; quantitative reverse transcript
Surface functionalized hollow manganese oxide nanoparticles for cancer targeted siRNA delivery and magnetic resonance imaging
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Bio-inspired; Manganese oxide; Nanoparticles; Magnetic resonance imaging; Small interfering RNA
siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Intra-placental gene delivery; Aspartyl-asparaginyl-β-hydroxylase; Notch; Intrauterine growth restriction; Ethanol; Small interfering RNA; In vivo transfection; Trophoblast migration
Adenovirus-Mediated SiRNA Targeting c-Met Inhibits Proliferation and Invasion of Small-Cell Lung Cancer (SCLC) Cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; small-cell lung cancer; small interfering RNA; proliferation; invasion; metastasis; adenovirus
Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) on endogenous gene expression
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; α-Cyclodextrin; Dendrimer; Conjugate; Endogenous gene expression; Cytotoxicity
Neuropharmacology and AnalgesiaKnockdown of the tachykinin neurokinin 1 receptor by intrathecal administration of small interfering RNA in rats
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Tachykinin neurokinin 1 receptor; Small interfering RNA; Knock down; Spinal cord; Scratching behavior; Inflammation;
A novel tumor-targeted delivery system with hydrophobized hyaluronic acid–spermine conjugates (HHSCs) for efficient receptor-mediated siRNA delivery
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Hyaluronic acid; Small interfering RNA; HA-receptor; Tumor-targeted; HA-receptor mediated endocytosis
Functional TNFα gene silencing mediated by polyethyleneimine/TNFα siRNA nanocomplexes in inflamed colon
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Poly (lactic acid) nanoparticle; Macrophages; Transfection; Polyethyleimine complex; Small interfering RNA; Mice colon
Tiny non-coding RNAs in Parkinson’s disease: Implications, expectations and hypes
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Tiny non-coding RNAs; Micro RNA; Small interfering RNA; Parkinson’s disease
Original ResearchBasic and Translational-Alimentary TractNeurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Neuropeptide; Colorectal Cancer; Signal Transduction; Tumor Suppressor; miRNA; microRNA; mRNA; messenger RNA; NF-κB; Nuclear factor-κB; NT; neurotensin; PCR; polymerase chain reaction; siRNA; small interfering RNA; UTR; untranslated region;
RNA interference targeting nucleocapsid protein (C) inhibits classical swine fever virus replication in SK-6 cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; RNA interference; Small interfering RNA; Nucleocapsid protein (C); Classical swine fever
Short interfering RNA targetting NF-kappa B induces apoptosis of hepatic stellate cells and attenuates extracellular matrix production
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Apoptosis; Hepatic stellate cells; NF-κB p65; Small interfering RNA
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Gastric cancer; Ribonucleotide reductase M2 subunit; Immunohistochemistry; Epstein-Barr virus; Small interfering RNA
Analysis of isoform specific ERK signaling on the effects of interleukin-1β on COX-2 expression and PGE2 production in human chondrocytes
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Cyclooxygenase 2; Interleukin 1β; Osteoarthritis; Prostaglandin E2; ERK1/2; Small interfering RNA
Identification of RNA-dependent DNA-methylation regulated promoters in Arabidopsis
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; RNA-dependent DNA methylation; Small interfering RNA; microRNA; Promoters; Transposable elements
Research ArticleExpression of CD133 confers malignant potential by regulating metalloproteinases in human hepatocellular carcinoma
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; HCC; hepatocellular carcinoma; VEGF; vascular endothelial growth factor; CSCs; cancer stem cells; MMP; matrix metalloproteinase; ADAM; a disintegrin and metalloproteinase; MICA; MHC class I-related chain A; Ab; antibody; siRNA; small interfering RNA; CD13
Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(γ-glutamic acid)
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Chitosan; Small interfering RNA; Poly(γ-glutamic acid); Transfection; Gene silencing
Inhibition of adenovirus infections by siRNA-mediated silencing of early and late adenoviral gene functions
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; RNAi, RNA interference; siRNA, small interfering RNARNA interference; Adenovirus infection; Small interfering RNA; Antiviral therapy
Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Drug delivery; Microsphere; Silica; Mesoporous; Controlled release; Single-chain antibody; Single-chain antibody variable fragment; Small interfering RNA
Research ArticleQuantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; RNAi; RNA interference; siRNA; small interfering RNA; shRNA; small-hairpin RNA; RISC; RNA-induced silencing complex; HBV; hepatitis B virus; IFN; interferon; sgRNA; subgenomic RNA; HBeAg; hepatitis B virus e antigen; pgRNA; pregenomic RNA; PCR; polymerase
RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Small interfering RNA; RNA interference; Inhalation; Functional siRNA delivery; Mouse; Lung
Towards graft-specific immune suppression: Gene therapy of the transplanted kidney
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Gene delivery; Kidney transplantation; Liposome; Plasmid; Rejection; Small interfering RNA; Tolerance; Virus
Ribonucleotide reductase small subunit p53R2 promotes oral cancer invasion via the E-cadherin/β-catenin pathway
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; p53R2; Invasion; E-cadherin; β-catenin; Small interfering RNA
Hepatic siRNA delivery using recombinant human apolipoprotein A-I in mice
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Recombinant apolipoprotein A-I; RNA interference; Small interfering RNA; Liver-specific delivery; Hepatitis C virus
siRNA targeting Survivin inhibits growth and induces apoptosis in human renal clear cell carcinoma 786-O cells
Keywords: RNA های خاموشگر، آران‌ای خاموشگر; Survivin; Apoptosis; Small interfering RNA; Renal clear cell carcinoma