کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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878081 | 911060 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications Porous-wall hollow glass microspheres as novel potential nanocarriers for biomedical applications](/preview/png/878081.png)
Porous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass material consisting of a 10- to 100-μm-diameter hollow central cavity surrounded by a 1-μm-thick silica shell. A tortuous network of nanometer-scale channels completely penetrates the shell. We show here that these channels promote size-dependent uptake and controlled release of biological molecules in the 3- to 8-nm range, including antibodies and a modified single-chain antibody variable fragment. In addition, a 6-nm (70-kDa) dextran can be used to gate the porous walls, facilitating controlled release of an internalized short interfering RNA. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anticancer drugs. The combination of a hollow central cavity that can carry soluble therapeutic agents with mesoporous walls for controlled release is a unique characteristic that distinguishes PW-HGMs from other glass materials for biomedical applications.From the Clinical EditorPorous-wall hollow glass microspheres (PW-HGMs) are a novel form of glass microparticles with a tortuous network of nanometer-scale channels. These channels allow size-dependent uptake and controlled release of biological molecules including antibodies and single-chain antibody fragments. PW-HGMs remained in place after mouse intratumoral injection, suggesting a possible application for the delivery of anti-cancer drugs.
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 6, Issue 1, February 2010, Pages 127–136