Hip2 interacts with and destabilizes Smac/DIABLO
Keywords: Hip2; Smac; Ubiquitination; Apoptosis
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Neuronal apoptosis inhibitory protein, NAIP, is an inhibitor of procaspase-9
Keywords: NAIP; XIAP; BIR3; Procaspase-9 inhibition; SMAC; Apoptosome
Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI
Keywords: BIR; baculoviral IAP repeat; caspase; cysteinyl aspartate-specific proteinase; CD; circular dichroism; Cyt c; cytochrome c; DIABLO; Direct IAP Binding protein with LOw pI; IPTG; isopropylthiogalactoside; LB; Luria-Bertani; Smac; Second Mitochondria-deri
Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure ‘biomarker’ signals and induction of inflammatory, innate immune and apoptotic pathways
Keywords: Pollution; Chronic exposure; Flounder; Microarray; Genomics; Benzo(a)pyrene; Estradiol; Diablo; Smac; Hepatocytes; Cyp1A; Vitellogenin
Improving the SMAC atmospheric correction code by analysis of Meteosat Second Generation NDVI and surface reflectance data
Keywords: Atmospheric correction; SEVIRI; SMAC; Radiative transfer; 6S; Meteosat Second Generation; NDVI; In-situ measurements
c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges
Keywords: Ago; Argonaute; DELFIA; Dissociation Enhanced Lathanide Fluoro-Immuno Assay; D-JNKI-1; cell-permeable JIP1-derived JNK inhibitory peptide-1 (D-amino acids); ELISA; enzyme-linked immunosorbent assays; ERK; extracellular signal-regulated kinase (ERK); FITC;
Inhibiting the inhibitors: Retro-inverso Smac peptides
Keywords: Apoptosis; Smac; Inhibitor of apoptosis proteins; Computational docking
An unstructured SMAC algorithm for thermal non-equilibrium two-phase flows
Keywords: Numerical method; SMAC; Two-fluid model; Unstructured grid;
Targeting post-mitochondrial effectors of apoptosis for neuroprotection
Keywords: ABD; ATP-binding domain; AIF; apoptosis-inducting factor; ANT; adenine nucleotide translocase; Antp HD; antennapedia homeodomain; Apaf-1; apoptotic peptidase activating factor 1; BH; Bcl-2 homology; BIR; baculoviral IAP repeat; boc-D-fmk; boc-Asp(OMe)-fmk
Wiskott-Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation
Keywords: WAS; Wiskott-Aldrich Syndrome; WASp; WAS protein; DC; dendritic cell; XLT; X-linked neutropenia; WAS KO; WASp knockout; VCA; verprolin homology, central and acidic; GBD; GTPase binding domain; TCR; T cell receptor; IS; immunological synapse; SMAC; supra
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
Keywords: XIAP; Smac; Apoptosis; Oncology; Rational drug design; Crystallography; NMR; Medicinal chemistry
Evidence for a pro-apoptotic phenotype in skeletal muscle of hypertensive rats
Keywords: Apoptosis; ARC; XIAP; Caspase-8; Smac; Oxidative stress; Skeletal muscle; Hypertension;
Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils
Keywords: Human; neutrophil; apoptosis; signal transduction; inflammation; asthma; CpdA; Compound A; ERK; Extracellular signal-regulated kinase; FasL; Fas ligand; FITC; Fluorescein isothiocyanate; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; GR; Glucocorticoid
Sensitive Ewing sarcoma and neuroblastoma cell lines have increased levels of BAD expression and decreased levels of BAR expression compared to resistant cell lines
Keywords: Apoptosis; Neuroblastoma; Ewing sarcoma; GS320 system; RAGEtags; BAR; BAD; SMAC
Effect of the XIAP Inhibitor Embelin on TRAIL-Induced Apoptosis of Pancreatic Cancer Cells
Keywords: apoptosis; caspase; Smac; pancreatic neoplasm; XIAP
Structure–activity based study of the Smac-binding pocket within the BIR3 domain of XIAP
Keywords: XIAP; Smac; Peptide mimetics; Apoptosis; Rational design; Oxazole
Role of XIAP in inhibiting cisplatin-induced caspase activation in non-small cell lung cancer cells: A small molecule Smac mimic sensitizes for chemotherapy-induced apoptosis by enhancing caspase-3 activation
Keywords: Lung cancer; Cisplatin-based chemotherapy; XIAP; Smac
Nuclear interaction of Smac/DIABLO with Survivin at G2/M arrest prompts docetaxel-induced apoptosis in DU145 prostate cancer cells
Keywords: Smac; Survivin; Mitotic apparatus; G2/M arrest; Apoptosis; Prostate cancer
Latent variable analysis of Raman spectra for structural characterization of proteins
Keywords: Raman spectroscopy; Lysozyme; Non-negative ICA; SMAC; SIMPLISMA; Chemometrics;
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics
Keywords: Smac; Peptido-mimetics; XIAP;
Leptin is an eosinophil survival factor
Keywords: Apoptosis; eosinophils; inflammation; leptin; signal transduction; ECP; Eosinophil cationic protein; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; MAPK; Mitogen-activated protein kinase; PI3K; Phosphatidylinositol-3-OH kinase; PS; Phosphatidylserine; S
Mathematical modeling of the regulation of caspase-3 activation and degradation
Keywords: Apoptosis; Caspases; Feedback control; Inhibitors of apoptosis; Smac;
Regulation of HtrA2/Omi by X-linked inhibitor of apoptosis protein in chemoresistance in human ovarian cancer cells
Keywords: Smac; second mitochondria-derived activator of caspases; IAP; inhibitor of apoptosis protein; cisplatin; cis-diamminedichloroplatinum (II); DMSO; dimethyl sulfoxide; DMEM; Dulbecco's Modified Eagle Medium; RPMI-1640; Roswell Park Memorial Institute 1640;
Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells
Keywords: DIABLO; direct IAP-binding protein with low PI; H2O2; hydrogen peroxide; IAPs; inhibitors of apoptosis proteins; Smac; the second mitochondria-derived activator of caspases; ROS; reactive oxygen species; COX II; cytochrome oxidase subunit II; DTT; dithiot
Dying a Thousand Deaths: Redundant Pathways From Different Organelles to Apoptosis and Necrosis
Keywords: Akt; proto-oncogene product of the viral oncogene v-akt; AIF; apoptosis inducing factor; Apaf-1; apoptotic protease activating factor-1; ATF6; activating transcription factor 6; Bad; heterodimeric partner for Bcl-xL and Bcl-2; Bak; Bcl2 homologous antagon
A dynamic view of the immunological synapse
Keywords: APC; antigen presenting cell; CFP; cyan fluorescent protein; DC; dendritic cell; eGFP; enhanced green fluorescent protein; HS; hemisynapse; ICAM; intercellular adhesion molecule; IS; immunological synapse; LFA; lymphocyte function associated; MHCp; major
A new approach for interactive self-modeling mixture analysis
Keywords: SIMPLISMA; SMAC; NMR; Chemometrics; Raman microspectroscopy;
Changes in spectrin organisation in leukaemic and lymphoid cells upon chemotherapy
Keywords: PKC; protein kinase C; SMAC; supramolecular activation complex; NF-κB; nuclear factor κB; IS; immunological synapse; TCR; T-cell receptor; TGF β; transforming growth factor β; ELF; embryonic liver fodrin; PBMCs; peripheral blood mononuclear cells; Non
Survivin interacts with Smac/DIABLO in ovarian carcinoma cells but is redundant in Smac-mediated apoptosis
Keywords: Survivin; Smac; Ovarian carcinoma cells;
Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds
Keywords: AITC; allyl-isothiocyanate; ARE; antioxidant response element; BITC; benzyl-isothiocyanate; DADS; diallyl disulfide; DAS; diallyl sulfide; DATS; diallyl trisulfide; HSPs; heat shock proteins; JNK; c-Jun N-terminal kinases; MAPKs; the mitogen-activated pro
On the outflow boundary condition for external incompressible flows: A new approach
Keywords: Outflow boundary condition; CFD; SMAC; Cylinder; Uniform flow; Strouhal number; Convective boundary condition; Low Reynolds number; Curvilinear coordinate system; Navier-Stokes equation;