کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10915315 | 1089900 | 2005 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of apoptosis in tumor cells by naturally occurring sulfur-containing compounds
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کلمات کلیدی
NAG-1DADSallyl-isothiocyanateBITCdiallyl trisulfideDATSPEITCPARPAITCHSPsSMACSFNNACS-allylmercaptocysteineSACDASPITCS-allylcysteineJnkNF-κBc-Jun N-terminal kinases - C-Jun N-terminal kinasesMAPKs - MAPK هاN-acetylcysteine - N-استیل سیستئینOSCs - OSC هاROS - ROSIsothiocyanates - ایزوتوسیانات هاOrganosulfur compounds - ترکیبات ارگاسفرومApoptosis - خزان یاختهایDiallyl disulfide - دی سولفید دیالیلdiallyl sulfide - دیالیل سولفیدSulforaphane - سولفورافانantioxidant response element - عنصر پاسخ آنتی اکسیدانnuclear factor kappa B - فاکتور هسته ای کاپا Bphenylethyl isothiocyanate - فین ایلتییل ایزوتیوسیاناتPhenyl isothiocyanate - فینیل ایزوتیوسیاناتARE - هستندHeat shock proteins - پروتئینهای شوک حرارتیPoly(ADP-ribose) polymerase - پلیمر (ADP-ribose) پلیمرازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chemoprevention is regarded as one of the most promising and realistic approaches in the prevention of human cancer. Among naturally occurring products, sulfur-containing compounds (OSCs), especially garlic compounds (GCs) and isothiocyanates (ITCs), represent two important and promising chemopreventive families because of their potent chemopreventive effects in various in vivo and in vitro models. In recent years, numerous investigations have shown that sulfur-containing compounds induce apoptosis in multiple cell lines and experimental animals. In the course of apoptosis induction by GCs and ITCs, multiple signal-transduction pathways and apoptosis intermediates are modulated. In particular, modulation of MAPKs and production of reactive oxygen species (ROS) seem to play pivotal roles in apoptosis induction by most GCs and ITCs. However, the role of P53 is still controversial. Based on present knowledge, GCs and ITCs may target not only the metabolism of carcinogens but also apoptosis signaling molecules. The effects of ITCs and GCs at multiple points of cancer development make these compounds highly promising candidates in cancer chemoprevention. However, the mechanisms of their anticancer effects are not fully understood, and further studies are required, especially to elucidate the role of cell-death receptors (the extrinsic pathway) and whether these agents induce apoptotic effects in non-tumor cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Reviews in Mutation Research - Volume 589, Issue 2, March 2005, Pages 81-102
Journal: Mutation Research/Reviews in Mutation Research - Volume 589, Issue 2, March 2005, Pages 81-102
نویسندگان
Xinjiang Wu, Fekadu Kassie, Volker Mersch-Sundermann,