Keywords: SNPC، جسم سیاه پارس متراکم; 5-HT, serotonin; BG, basal ganglia; DA, dopamine; DD, constant darkness; LD, light–dark; Mn, Manganese; NE, norepinephrine; NHP, non-human primate; PD, Parkinson’s disease; SCN, suprachiasmatic nucleus; SNpc, substantia nigra pars compacta; SWS, slow wave
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Keywords: SNPC، جسم سیاه پارس متراکم; PD, Parkinson’s disease; DA, dopamine; DOPAC, dihydroxyphenylacetic acid; TH, tyrosine hydroxylase; SNpc, substantia nigra pars compacta; GI, gastrointestinal; ENS, enteric nervous system; OB, olfactory bulb; AON, anterior olfactory nucleusParkinson’s dis
Keywords: SNPC، جسم سیاه پارس متراکم; PD, Parkinson’s disease; DAergic, dopaminergic; SNpc, substantia nigra pars compacta; DA, dopamine; LB, lewy body; α-syn, alpha synuclein; L-DOPA, levodopa; MAO, monoamine oxidase; CNS, central nervous system; DDS, drug delivery systems; MPs, microparticl
Neuroprotective effects of ginsenoside Rg1 through the Wnt/β-catenin signaling pathway in both in vivo and in vitro models of Parkinson's disease
Keywords: SNPC، جسم سیاه پارس متراکم; Parkinson's disease; Neurodegeneration; Neuroprotection; Ginsenoside Rg1; Wnt/β-catenin signaling pathwayRg1, ginsenoside Rg1; PD, Parkinson's disease; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahy
Chronic mild stress accelerates the progression of Parkinson's disease in A53T α-synuclein transgenic mice
Keywords: SNPC، جسم سیاه پارس متراکم; PD, Parkinson's disease; CMS, chronic mild stress; LB, Lewy body; 6-OHDA, 6-hydroxy-dopamine; DA, dopamine; CORT, corticosterone; TH, tyrosine hydroxylase; Iba-1, ionized calcium-binding adaptor molecule 1; SNpc, substantia nigra pars compacta; DOPAC, dih
Transient glutathione depletion in the substantia nigra compacta is associated with neuroinflammation in rats
Keywords: SNPC، جسم سیاه پارس متراکم; BSO, l-buthionine sulfoximine; CS, corpus striatum; IL, interleukin; JNK, c-Jun N-terminal kinase; NO, nitric oxide; PD, Parkinson’s disease; ROS, reactive oxygen species; SNpc, substantia nigra pars compacta; TNF, tumor necrosis factor; UTR, untreated; V
Dopamine transporter imaging in the aged rat: a [123I]FP-CIT SPECT study
Keywords: SNPC، جسم سیاه پارس متراکم; DA, Dopamine; DAT, Dopamine Transporter; PD, Parkinson's Disease; PET, Positron Emission Tomography; ROI, Region Of Interest; SNpc, Substantia Nigra pars compacta; SPECT, Single Photon Emission Computed Tomography; SUR, Specific Uptake Ratio; SUV, Standar
Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
Keywords: SNPC، جسم سیاه پارس متراکم; IF, Interfascicular nucleus; PN, Paranigral nucleus; PBP, Parabrachial pigmented nucleus; SNpc, Substantia nigra pars compacta; VTA, Ventral tegmental areaOtx2; Neuronal identity; Dopaminergic progenitors; Ventral tegmental area; Substantia nigra; En1
Computational evaluation of small molecule inhibitors of RGS4 to regulate the dopaminergic control of striatal LTD
Keywords: SNPC، جسم سیاه پارس متراکم; RGS, Regulator of G protein; SNpc, Substantia Nigra pars compacta; mGluR, metabotropic glutamate receptors; MSNs, Mini Spinny Neurons; LTD, Long Term Depression; eCB, endocannabinoid; AMP, Adenosine Mono Phosphate; PKA, phosphorykinase A; L-VGCCs, L-type
Effect of intermittent washout periods on progressive lesioning of the nigrostriatal pathway with 1-methyl-2-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Keywords: SNPC، جسم سیاه پارس متراکم; dopamine; progressive; MPTP; tyrosine hydroxylase; motor control; Parkinson's diseaseCPu, caudate putamen; DA, dopamine; FSR, free-standing rears; PD, Parkinson's disease; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylase; TH-ir, TH-immunorea
Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q10 pretreatment
Keywords: SNPC، جسم سیاه پارس متراکم; SN, substantia nigra; ROS, reactive oxygen species; TH, tyrosine hydroxylase; PD, Parkinson's disease; SNpc, substantia nigra pars compacta; OP, organophosphate; CS, corpus striatumCoenzyme Q10; Parkinson's disease; Dichlorvos; Nigrostriatal neurodegenera
Morphological and functional alterations in the substantia nigra pars compacta of the Mecp2-null mouse
Keywords: SNPC، جسم سیاه پارس متراکم; RTT, Rett syndrome; Mecp2, methyl-CpG binding protein 2; SNpc, substantia nigra pars compacta; Th, tyrosine hydroxylase; pSer40-Th, serine40-phosphorylated tyrosine hydroxylase; mDA, midbrain dopaminergic; Pitx3, paired-like homeobox gene 3; Vmat2, vesicu
Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake
Keywords: SNPC، جسم سیاه پارس متراکم; Parkinson's disease; 1-Methyl-4-phenylpyridinium (MPP+); Divalent metal transporter 1 (DMT1); NF-κB; Rg1SN, substantia nigra; SNpc, substantia nigra pars compacta; PD, Parkinson's disease; MPP+, 1-methyl-4-phenylpyridinium; DMT1, divalent metal transporte
Number and nuclear morphology of TH+ and TH− neurons in the mouse ventral midbrain using epifluorescence stereology
Keywords: SNPC، جسم سیاه پارس متراکم; SNpc, substantia nigra pars compacta; SNpl, substantia nigra pars lateralis; RRF, retrorubral field; VTA, ventral tegmental area; IHC, immunohistochemistry; PBS, phosphate buffered saline; PFA, paraformaldehyde; TH, tyrosine hydroxylase; DAPI, 4',6-diamid
Cytotoxicity of dopaminochrome in the mesencephalic cell line, MN9D, is dependent upon oxidative stress
Keywords: SNPC، جسم سیاه پارس متراکم; DAC, dopaminochrome; SNpc, substantia nigra pars compacta; PD, Parkinson disease; GSH, reduced glutathione; GSSG, oxidized glutathione; DHE, dihydroethidium; DMEM, Dulbecco's modified Eagle's MediumNeurodegeneration; Parkinson disease; Dopamine; Glutathio
Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment
Keywords: SNPC، جسم سیاه پارس متراکم; PD, Parkinson's disease; DA, dopamine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylaseParkinson's disease; Substantia nigra; Dopamine; Synaptic zinc; Apoptosis
Diadenosine tetraphosphate reduces toxicity caused by high-dose methamphetamine administration
Keywords: SNPC، جسم سیاه پارس متراکم; AP4A, diadenosine tetraphosphate; DIV, days in vitro; DA, dopamine; BSA, bovine serum albumin; 6-OHDA, 6-hydroxydopamine; MA, methamphetamine; PFA, paraformaldehyde; SNpr, substantia nigra pars reticulate; SNpc, substantia nigra pars compacta; TUNEL, term
A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL/6J mouse
Keywords: SNPC، جسم سیاه پارس متراکم; dopaminergic neuron; Parkinson's disease; stereology; cell countsDA, dopaminergic; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydopyridine; PBS, phosphate-buffered saline; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylase
Effect of unilateral lesion of the nigrostriatal dopamine pathway on survival and neurochemistry of parafascicular nucleus neurons in the rat — Evaluation of time-course and LGR8 expression
Keywords: SNPC، جسم سیاه پارس متراکم; 6-OHDA, 6-hydroxydopamine; INSL3, insulin-like peptide 3; LGR8, leucine-rich repeat containing G-protein coupled receptor 8; Pf, parafascicular nucleus; SNpc, substantia nigra pars compacta; vGlut2, vesicular glutamate transporter-2Substantia nigra; 6-Hyd
Involvement of subthalamic nucleus in the stimulatory effect of Δ9-tetrahydrocannabinol on dopaminergic neurons
Keywords: SNPC، جسم سیاه پارس متراکم; cannabinoid; basal ganglia; excitatory amino acids; electrophysiologyANOVA, analysis of variance; EAA, excitatory amino acid; PBS, phosphate buffer saline; SNpc, substantia nigra pars compacta; STN, subthalamic nucleus; Δ9-THC, Δ-9-tetrahydrocannabinol
Sporadic midbrain dopamine neuron abnormalities in laboratory mice
Keywords: SNPC، جسم سیاه پارس متراکم; PD, Parkinson's disease; PDP, Parkinson's disease phenotype; VM, ventral midbrain; STR, striatum; FCtx, frontal cortex; DA, dopamine; DAergic, dopaminergic; DOPAC, dihydroxyphenylacetic acid; HVA, homovanillic acid; SNpc, substantia nigra pars compacta; V
Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells
Keywords: SNPC، جسم سیاه پارس متراکم; DA, dopamine; DAT, dopamine transporter; ES, embryonic stem; ES-N, embryonic stem cell-derived neuron-like; MAP2, microtubule-associated protein-2; MCAO, middle cerebral artery occlusion; SNpc, substantia nigra pars compacta; TH, tyrosine hydroxylaseMouse