کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1917019 1535303 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Brain aging and Parkinson’s disease: New therapeutic approaches using drug delivery systems
ترجمه فارسی عنوان
پیری مغزی و بیماری پارکینسون: روش‌های درمانی جدید با استفاده از سیستم های تحویل دارویی
کلمات کلیدی
PD، بیماری پارکینسون؛ DAergic، dopaminergic؛ SNPC، substantia nigra pars compacta؛ DA، دوپامین؛ LB، بدن نازک؛ α-syn، آلفا سینوکلین؛ L-DOPA، لوودوپا؛ MAO، monoamine oxidase؛ CNS، سیستم عصبی مرکزی؛ DDS، سیستم های تحویل دارو؛ میکروپارتیکال
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• The etiology of Parkinson’s disease (PD) is unknown, aging being the strongest risk factor for brain degeneration.
• The most promising therapeutic targets and strategies to delay the loss of dopaminergic neurons observed both in PD and aging are reviewed.
• The latest types of drug delivery system (DDS)-based strategies for PD treatment are summarized.
• The ongoing challenges for the discovery of new targets and the opportunities for DDS-based therapies discussed.
• The emerging strategies summarized in the review show promise for better therapies for PD.

The etiology and pathogenesis of Parkinson’s disease (PD) is unknown, aging being the strongest risk factor for brain degeneration. Understanding PD pathogenesis and how aging increases the risk of disease would aid the development of therapies able to slow or prevent the progression of this neurodegenerative disorder. In this review we provide an overview of the most promising therapeutic targets and strategies to delay the loss of dopaminergic neurons observed both in PD and aging. Among them, handling alpha-synuclein toxicity, enhancing proteasome and lysosome clearance, ameliorating mitochondrial disruptions and modifying the glial environment are so far the most promising candidates. These new and conventional drugs may present problems related to their labile nature and to the difficulties in reaching the brain. Thus, we highlight the latest types of drug delivery system (DDS)-based strategies for PD treatment, including DDS for local and systemic drug delivery. Finally, the ongoing challenges for the discovery of new targets and the opportunities for DDS-based therapies to improve and efficacious PD therapy will be discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Maturitas - Volume 84, February 2016, Pages 25–31
نویسندگان
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