Sex-determining region Y-box 2 amplification in preneoplastic squamous lesions of the lung
Keywords: Lung; Squamous preneoplasia; SOX2;
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SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells
Keywords: SOX2; EGFR; Self-renewal; Prostate cancer stem cell;
MicroRNA expression profiling of human bone marrow mesenchymal stem cells during osteogenic differentiation reveals Osterix regulation by miR-31
Keywords: 3â²UTR; 3â² untranslated region; ALP; Alkaline phosphatase; AP-1; Activator protein 1; ATF4; Activating transcription factor 4; BGLAP; Bone gamma-carboxyglutamate (gla) protein; BMP; Bone morphogenetic protein; COL1A1; Collagen, type I, alpha 1; FBS; Fe
Genomic code for Sox2 binding uncovers its regulatory role in Six3 activation in the forebrain
Keywords: Sox2; Six3; Forebrain; ChIP Display; Mouse;
MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2
Keywords: Colorectal cancer; MiR-429; Prognosis; Apoptosis; SOX2
Forkheadbox N4 (FoxN4) triggers context-dependent differentiation in the developing chick retina and neural tube
Keywords: AC, Amacrine cell; E, Embryonic day; FoxN4, Forkhead box N4; GC, Ganglion cell; HC, Horizontal cell; PR, Photoreceptor cell; RPC, Retinal Progenitor Cell; st, developmental stageChicken; Retinal development; Lim1; Prox1; Retinal progenitor cells; Sox2
Developing a sense of taste
Keywords: CVP, circumvallate papilla; RTK, tyrosine kinase receptorMouse; Zebrafish; Molecular genetics; Sox2; Wnt; Shh; Notch; Fgf; miR-200
Coexpression of B-lymphoma Moloney murine leukemia virus insertion region-1 and sex-determining region of Y chromosome–related high mobility group box-2 in cervical carcinogenesis
Keywords: BMI1; SOX2; Cervical cancer; Carcinogenesis
Perspectives on cancer stem cells in osteosarcoma
Keywords: Osteosarcoma; Cancer stem cell; Tumor initiating cell; Mesenchymal tumors; Bone cancer; Sox2; FGF; Wnt signaling
SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network
Keywords: SOX2; Tumor metastasis; EMT; β-catenin; TGF-β1
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors
Keywords: Endometriosis; microRNA; stem cells; MSI2; SOX2;
Positive regulation of additional sex comb-like 1 gene expression by the pluripotency factor SOX2
Keywords: ASXL1, additional sex comb-like 1; SOX2, Sry-related HMG Box 2; WB, western blotting; β-gal, β-galactosidase; Luc, luciferase; shRNA, small hairpin RNA; KD, knockdown; ChIP, chromatin immunoprecipitationASXL1; SOX2; Promoter; Transcription; Stem cells
Role of the Stemness Factors Sox2, Oct3/4, and Nanog in Gastric Carcinoma
Keywords: gastric carcinoma; cancer stem cells; Sox2
Inherent propensity of amnion-derived mesenchymal stem cells towards endothelial lineage: Vascularization from an avascular tissue
Keywords: Angiogenesis; Mesenchymal stem cells; Endothelial lineage; Amniotic membrane; Oct4; Octamer binding factor 4; Sox2; sex determining region Y-box 2; SSEA; Stage specific embryonic antigen; Klf4; Kruppel-like factor; RT-PCR; Reverse transcriptase polymerase
The neural adhesion molecule L1CAM confers chemoresistance in human glioblastomas
Keywords: bFGF; basic fibroblast growth factor; BSA; bovine serum albumin; DMEM; Dulbecco's Modified Eagle Medium; DMSO; dimethylsulfoxide; EGF; epidermal growth factor; FCS; fetal calf serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GBM; glioblastoma mul
Expression pattern of Sox2 during mouse tooth development
Keywords: Sox2; Epithelium stem cell; Apical bud; Mouse odontogenesis
Notch signaling pathway regulates proliferation and differentiation of immortalized Müller cells under hypoxic conditions in vitro
Keywords: BrdU; 5-bromo-2â²-deoxyuridine; CRALBP; cellular retinaldehyde-binding protein; DAPI; 4â²,6-diamidino-2-phenylindole; DAPT; N-[N-(3, 5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester; ERK; extracellular signal-regulated kinase; FGF2; fibrobl
Cationic polyurethanes-short branch PEI-mediated delivery of Mir145 inhibited epithelial–mesenchymal transdifferentiation and cancer stem-like properties and in lung adenocarcinoma
Keywords: Lung adenocarcinoma; miR145; Oct4; Sox2; Fascin1; Epithelial–mesenchymal transdifferentiation
Genetic and cellular mechanisms regulating anterior foregut and esophageal development
Keywords: EA/TEF; Sox2; BMP; Esophageal muscle; Myenteric system
Human amniotic epithelial cell feeder layers maintain human iPS cell pluripotency via inhibited endogenous microRNA-145 and increased Sox2 expression
Keywords: Human amniotic epithelial cells; Feeder layer; Human induced pluripotent stem cells; Sox2; MicroRNA-145; Pluripotency
Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation
Keywords: ATRA; all-trans retinoic acid; CL; cerebellum; CX; cerebral cortex; DIV; days in vitro; DMEM; Dulbecco's modified Eagle's medium; ERGO; ergothioneine; FBS; fetal bovine serum; GAP43; growth-associated protein 43; HC; hippocampus; HO-1; heme oxygenase-
SOX2 hypomorphism disrupts development of the prechordal floor and optic cup
Keywords: Sox2; Prechordal floor; Optic cup; Optic stalk; Shh; Patterning;
Specific domains of FoxD4/5 activate and repress neural transcription factor genes to control the progression of immature neural ectoderm to differentiating neural plate
Keywords: Neural induction; sox2; sox3; sox11; soxD; zic2; zic1; zic3; irx1; irx2; irx3; Transcription; foxD4; foxD4L1;
Stem cells as the root of pancreatic ductal adenocarcinoma
Keywords: ABC; ATP binding cassette; ALDH1; Aldehyde dehydrogenase 1a1; Arx; Aristalless-related homeobox; EMT; Epithelial-to-mesenchymal transition; CAC; Centroacinar cells; CD; Cluster of differentiation; CDKN2A; Cyclin-dependent kinase inhibitor 2A; CSC; Cancer
Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways
Keywords: Foxm1; Clara cells; Airway epithelium; Type II cells; Sox2; Airway development
Sox2 nuclear expression is closely associated with poor prognosis in patients with histologically node-negative oral tongue squamous cell carcinoma
Keywords: Oral tongue squamous cell carcinoma; Sox2; Immunohistochemistry; Prognosis;
Intracellular reactivation of transcription factors fused with protein transduction domain
Keywords: PTD; iPS cells; ES cells; Oct3/4; Sox2; TEV protease
Arsenic trioxide regulates the apoptosis of glioma cell and glioma stem cell via down-regulation of stem cell marker Sox2
Keywords: Arsenic trioxide; Sox2; Apoptosis; Glioma; Glioma stem cell
Research ReportEffect of melatonin on mRNA expressions of transcription factors in murine embryonic stem cells
Keywords: Melatonin; Embryonic stem cell; p-Akt; Oct4; REX-1; Sox2; Zfp206;
Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa
Keywords: Sox2; Cdx2; Intestinal metaplasia; Transgenic mouse
Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear
Keywords: Zebrafish; atoh1a/b; sox2; fgf3; fgf8; Hair cell; Support cell; Heat shock;
Eye development genes and known syndromes
Keywords: Anophthalmia/Microphthalmia; SOX2; Anophthalmia-Esophageal-Genital (AEG) syndrome; OTX2;
Septo-optic dysplasia and other midline defects: The role of transcription factors: HESX1 and beyond
Keywords: Septo-optic dysplasia; pituitary; HESX1; SOX2; SOX3; OTX2
Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis
Keywords: Pituitary; Corticotrope; Melanotrope; Notch; HPA axis; SOX2;
Ouabain–Induced Auditory Nerve Degeneration in Congenic Ly5.1 Mice
Keywords: primary auditory nerve; Ly5.1 mouse; Ouabain; neural degeneration; Sox2; BrdU; glial cells
Utility of 10 Immunohistochemical Markers Including Novel Markers (Desmocollin-3, Glypican 3, S100A2, S100A7, and Sox-2) for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung
Keywords: Squamous cell carcinoma; Lung; Cytokeratin 5/6; Sox2; Desmocollin-3
Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle
Keywords: Self-administration; Subgranular zone; Psychostimulant; BrdU; CldU; IdU; GFAP; Sox2; Ki-67; DCX; AC3;
SOX2 amplification is a common event in squamous cell carcinomas of different organ sites
Keywords: SOX2; Squamous Cell carcinoma; Skin; Penis; Uterine cervix
Regional and laminar differences in antigen profiles and spatial distributions of astrocytes in the mouse hippocampus, with reference to aging
Keywords: aging; antigen profile; astrocytes; heterogeneity; hippocampus; spatial distribution; DAPI; 4â²,6-diamidino-2-phenylindole; GFAP; glial fibrillary acidic protein; NDs; numerical densities; PBS; buffered saline; PDGFaR; platelet derived growth factor alph
Induced pluripotent stem cells: AÂ novel frontier in the study of human primary immunodeficiencies
Keywords: Primary immunodeficiency; induced pluripotent stem cells; reprogramming; bFGF; Basic fibroblast growth factor; cMYC; Cellular myelomonocytic proto-oncogene; hES; Human embryonic stem; iMEFs; Irradiated murine embryonic fibroblast; iPSC; Induced pluripoten
The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates
Keywords: Sox2; Enhancer N2; POU factors; ES cells; Epiblast; Anterior neural plate; Mouse; Chicken; Zebrafish;
Sox2 roles in neural stem cells
Keywords: Sox2; Neural stem cells; Gene regulation; Neural development; Animal models
Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer
Keywords: Small-cell lung cancer; SOX2; Antibodies; Survival; Phenotype; Prognosis
SOX2 modulates alternative splicing in transitional cell carcinoma
Keywords: SOX2; Alternative splicing; Transitional cell carcinoma
Transplantable midbrain dopamine neurons: A moving target
Keywords: mDA; midbrain dopaminergic; VZ; ventricular zone; IZ; intermediate zone; MZ; mantle zone; VTA; ventral tegmental area; SN; substantia nigra; Nurr1; nurr77-related receptor 1; PD; Parkinson's disease; TH; tyrosine hydroxylase; VM; ventral mesencephalon; So
Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells
Keywords: Glioma; Glioma-initiating cell; Sox2; Self-renewal; eIF4E
Methylation patterns in 5′ terminal regions of pluripotency-related genes in bovine in vitro fertilized and cloned embryos
Keywords: bovine; DNA methylation; Fgf4; Nanog; Oct4; Rex1; Sox2
Expression of Sox2 in human cervical carcinogenesis
Keywords: Cervical cancer; Sox2; Cancer stem cells; Carcinogenesis
Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells
Keywords: ES cells; iPS cells; miRNAs; Reprogramming; Sox2; Oct4;
Stem cells in the pituitary gland: A burgeoning field
Keywords: Pituitary; Stem cells; Progenitor cells; Side population; Sox2; Prop1; Notch; Nestin; Folliculostellate cells; Pituispheres; Cancer stem cells; Pituitary adenomaACE, angiotensin-converting enzyme; ACTH, adrenocorticotropic hormone; AP, anterior pituitary;