Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis

► Activated Notch inhibits the differentiation of corticotropes and melanotropes. ► Activated Notch induces the expression of progenitor markers in POMC cells. ► Melanotropes and corticotropes fail to regenerate. ► Improper Notch signaling in corticotropes leads to dysfunction of the HPA axis.