Keywords: کانال کلسیم T نوع; Fibromodulin; L-type calcium channel; T-type calcium channel; Myoblast; Myogenesis;
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Keywords: کانال کلسیم T نوع; T-type calcium channel; 3,4-Dihydroquinazoline; Bioisostere; Cytotoxic activity; Inflammatory pain; Liver microsomal stability;
Keywords: کانال کلسیم T نوع; T-type calcium channel; Neuritogenesis; Sensory neuron
Keywords: کانال کلسیم T نوع; T-type calcium channel; Hydrogen sulfide; C-fiber nociceptor
Effects of the iron chelator deferiprone and the T-type calcium channel blocker efonidipine on cardiac function and Ca2+ regulation in iron-overloaded thalassemic mice
Keywords: کانال کلسیم T نوع; ATP; adenosine triphosphate; [Ca2+]i; intracellular calcium; CICR; calcium-induced calcium release; DFP; deferiprone; EF; ejection fraction; EFO; efonidipine; FE; iron diet; FS; fraction shortening; HRV; heart rate variability; HT; β-thalassemic type; IC
Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels
Keywords: کانال کلسیم T نوع; Pain; Benzothiazole; CaV2.2; N-type calcium channel; CaV3.2; T-type calcium channel;
Combined iron chelator and T-type calcium channel blocker exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice
Keywords: کانال کلسیم T نوع; Thalassemia; T-type calcium channel; Iron chelator; Iron overload cardiomyopathy; Apoptosis;
A constitutively-active IKK-complex at the axon initial segment
Keywords: کانال کلسیم T نوع; Axon initial segment; NF-κB; IKK 2 Kinase; Ankyrin-G; Proximity ligation assay; Axon; AIS; axon initial segment; ASA; acetyl-salicylic acid; DMEM; Dulbecco's modified Eagle media; eGFP; enhanced green-fluorescent protein; FADD; Fas-associated death dom
CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons
Keywords: کانال کلسیم T نوع; Ventral tegmental area; Dopamine; T-type calcium channel; TTA-P2; Rebound spiking; Burst firing; Low-voltage-activated; LVA; low-voltage-activated; TEA-OH; tetraethylammonium hydroxide; TMA-OH; tetramethylammonium hydroxide; TTX; tetrodotoxin; TTA-P2; 3,5
Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice
Keywords: کانال کلسیم T نوع; T-type calcium channel; 6-Prenylnaringenin; Sophoraflavanone G; Neuropathic pain; Visceral pain; HVA-current; high-voltage-activated Ca2+ channel-dependent current; Nav-current; voltage-dependent Na+ channel-dependent current; NG; naringenin; OHP; oxalipl
Negative myoclonus induced by gabapentin and pregabalin: A case series and systematic literature review
Keywords: کانال کلسیم T نوع; Negative myoclonus; Pregabalin; Gabapentin; Renal function; T-type calcium channel;
Discovery and evaluation of Cav3.1-selective T-type calcium channel blockers
Keywords: کانال کلسیم T نوع; AcOH; acetic acid; 9-BBN; 9-borabicyclo(3.3.1)nonane; DAST; diethylaminosulfur trifluoride; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; EDC·HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochlorid
Discovery and evaluation of Cav3.2-selective T-type calcium channel blockers
Keywords: کانال کلسیم T نوع; AcOH; acetic acid; Boc; tert-butylocycarbonyl; DIPEA; N,N-diisopropylethylamine; DMAP; 4-(dimethylamino)pyridine; DMF; N,N-dimethylformamide; EDC·HCl; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride; HOBt; hydroxybenzotriazole; KHMDS; potassi
Chronic intrathecal infusion of T-type calcium channel blockers attenuates CaV3.2 upregulation in nerve-ligated rats
Keywords: کانال کلسیم T نوع; CaV3.2; intrathecal; neuropathic pain; neurotoxicity; T-type calcium channel;
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells
Keywords: کانال کلسیم T نوع; Cell cycle arrest; Synergistic effect; T-type calcium channel; Human lung cancer; Apoptosis
Cd2+ sensitivity and permeability of a low voltage-activated Ca2+ channel with CatSper-like selectivity filter
Keywords: کانال کلسیم T نوع; Patch clamp; Heterologous expression; Fluorescence imaging; CatSper selectivity filter; T-type calcium channel
H2S does not regulate proliferation via T-type Ca2+ channels
Keywords: کانال کلسیم T نوع; Proliferation; T-type calcium channel; Gasotransmitter; Vascular smooth muscle; Hydrogen sulfide
Functional upregulation of the H2S/Cav3.2 channel pathway accelerates secretory function in neuroendocrine-differentiated human prostate cancer cells
Keywords: کانال کلسیم T نوع; Hydrogen sulfide; T-type calcium channel; Prostate cancer; Neuroendocrine differentiation
Regulation of T-type calcium channel expression by sodium butyrate in prostate cancer cells
Keywords: کانال کلسیم T نوع; LNCaP; lymph node carcinoma of the prostate; NaBu; sodium butyrate; NED; neuroendocrine differentiation; SAHA; suberoylanilide hydroxamic acid; 5׳-azaC; 5-azacytidine; NNC 55-0396 (PubChem CID: 11957578); Paclitaxel (PubChem CID: 36314); Sodium butyrate
Posttranscriptional regulation of T-type Ca2+ channel expression by interleukin-6 in prostate cancer cells
Keywords: کانال کلسیم T نوع; CHX, cycloheximide; FSK, forskolin; IL-6, interleukin-6; LNCaP, lymph node carcinoma of the prostate; NaBu, sodium butyrate; NED, neuroendocrine differentiationProstate cancer; Interleukin-6; Forskolin; T-type calcium channel; Neuroendocrine differentiati
Differential CaMKII regulation by voltage-gated calcium channels in the striatum
Keywords: کانال کلسیم T نوع; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CaMKII; calcium/calmodulin-dependent protein kinase II; LTCC; L-type calcium channel; MSN; medium spiny neuron; RTCC; R-type calcium channel; TTCC; T-type calcium channel; VGCC; voltag
Endogenous and exogenous hydrogen sulfide facilitates T-type calcium channel currents in Cav3.2-expressing HEK293 cells
Keywords: کانال کلسیم T نوع; H2S; hydrogen sulfide; CSE; cystathionine-γ-lyase; CBS; cystathionine-β-synthase; T-channel; T-type Ca2+ channel; TRPA1; transient receptor potential ankyrin-1; T-current; T-channel-dependent current; PPG; dl-propargylglycine; Cav3.2-HEK293; Cav3.2-tran
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist
Keywords: کانال کلسیم T نوع; T-type calcium channel; Antagonist; Human lung adenocarcinoma (A549) cells; Pancreatic cancer (MiaPaCa2) cells; Apoptosis; Cell cycle arrest; Caspases;
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production
Keywords: کانال کلسیم T نوع; Aging; Alzheimer's disease; Calcium; T-type calcium channel; APP processing; Amyloid; Calpains;
Ethosuximide reduces electrographical and behavioral correlates of alcohol withdrawal seizure in DBA/2J mice
Keywords: کانال کلسیم T نوع; Alcohol; Withdrawal; Seizure; Ethosuximide; T-type calcium channel;
T-type calcium channels in burst-firing, network synchrony, and epilepsy
Keywords: کانال کلسیم T نوع; T-type calcium channel; Low-threshold spike; Low-threshold calcium potential; Burst-firing; Neural network; Epilepsy; Thalamocortical system;
STIM1 participates in the contractile rhythmicity of HL-1 cells by moderating T-type Ca2Â + channel activity
Keywords: کانال کلسیم T نوع; [Ca2Â +]i; concentration of intracellular free Ca2Â +; AFM; atomic force microscopy; CICR; Ca2Â +-induced Ca2Â + release; CRAC; Ca2Â +-release activated Ca2Â + channel; ICa; Ca2Â + current; ICa,T; T-type Ca2Â + current; L-VDCC; L-type voltage-dependent ca
State-dependent properties of a new T-type calcium channel blocker enhance CaV3.2 selectivity and support analgesic effects
Keywords: کانال کلسیم T نوع; Analgesia; Colonic hypersensitivity; IBS; Somatic pain; T-type calcium channel;
The Antinociceptive Activity of Intrathecally Administered Amiloride and Its Interactions With Morphine and Clonidine in Rats
Keywords: کانال کلسیم T نوع; Analgesics; amiloride; opioid; α2-adrenergic agonist; T-type calcium channel
Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats
Keywords: کانال کلسیم T نوع; Tremor; Parkinson's disease; T-type calcium channel; Zonisamide; Ethosuximide
Pyridyl amides as potent inhibitors of T-type calcium channels
Keywords: کانال کلسیم T نوع; T-type calcium channel; Structure–activity relationships; Pregnane X receptor; Electrocorticogram; Epilepsy
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers
Keywords: کانال کلسیم T نوع; T-type calcium channel; Neuropathic pain
Expression and characterization of recombinant kurtoxin, an inhibitor of T-type voltage-gated calcium channels
Keywords: کانال کلسیم T نوع; C; cysteine; CD; circular dichroism; IPTG; isopropyl β-d-thiogalactoside; MALDI-TOF MS; matrix-assisted laser desorption/ionization-time of flight mass spectrometry; NMR; nuclear magnetic resonance; PCR; polymerase chain reaction; RP-HPLC; reverse-phase
Comparison of mibefradil and derivative NNC 55-0396 effects on behavior, cytochrome P450 activity, and tremor in mouse models of essential tremor
Keywords: کانال کلسیم T نوع; Essential tremor; Harmaline; Mibefradil; NNC 55-0396; T-type calcium channel; Anti-tremor drug
Inhibition of T-type calcium channels and hydrogen sulfide-forming enzyme reverses paclitaxel-evoked neuropathic hyperalgesia in rats
Keywords: کانال کلسیم T نوع; T-type calcium channel; hydrogen sulfide; neuropathic pain; chemotherapy; hyperalgesiaAS, antisense; BCA, β-cyanoalanine; CBS, cystathionine-β-synthase; CSE, cystathionine-γ-lyase; DRG, dorsal root ganglia; GAPDH, glyceraldehyde-3-phosphate dehydrogenase;
Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells
Keywords: کانال کلسیم T نوع; extracellular signal-regulated kinase 1 and 2; c-jun amino terminal kinase1; neuronal differentiation; T-type calcium channel; L-type calcium channelBMP, bone morphogenetic proteins; EB, embyoid body; ERK1/2, extracellular signal-regulated kinase 1 and 2;
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA)
Keywords: کانال کلسیم T نوع; CoMSIA; 3D QSAR; T-Type calcium channel; 3,4-Dihydroquinazoline
Design, syntheses, and SAR of 2,8-diazaspiro[4.5]decanones as T-type calcium channel antagonists
Keywords: کانال کلسیم T نوع; T-type calcium channel; CaV3.2; Diazaspirodecanones
Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers
Keywords: کانال کلسیم T نوع; T-type calcium channel; HTS assay; α1G Subtype; Neuropathic pain; Oxazole;
Baccoside A suppresses epileptic-like seizure/convulsion in Caenorhabditis elegans
Keywords: کانال کلسیم T نوع; Epileptic-like seizure; Convulsion; Ca2+ oscillations; T-type calcium channel; Baccoside A; Caenorhabditis elegans
Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists
Keywords: کانال کلسیم T نوع; Quinazolin-2-ones; Calcium channel antagonists; T-Type calcium channel; Epilepsy
Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells
Keywords: کانال کلسیم T نوع; SH-SY5Y; NMDA receptor; L-type calcium channel; T-type calcium channel; PKA; PKC
Inhibition of recombinant Cav3.1 (α1G) T-type calcium channels by the antipsychotic drug clozapine
Keywords: کانال کلسیم T نوع; T-type calcium channel; Cav3.1; α1G subunit; Clozapine; Antipsychotics; Neuroleptics
Upregulation of Cav3.2 T-type calcium channels targeted by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain
Keywords: کانال کلسیم T نوع; Pain; Neuropathic pain; T-type calcium channel; Hyperalgesia; RNA interference; Hydrogen sulfide;
Inhibition of the activation pathway of the T-type calcium channel CaV3.1 by ProTxII
Keywords: کانال کلسیم T نوع; T-type calcium channel; ProTxII; Voltage gated; Gating modifier toxinCaV3.1, The T-type voltage-gated Ca channel isoform; NaV1.5, The heart isoform of the voltage-gated Na channel; NaV1.2, The neuronal isoform of the voltage-gated Na channel
Regulation of T-type calcium channels: Signalling pathways and functional implications
Keywords: کانال کلسیم T نوع; T-type calcium channel; Low-voltage activated; G-protein coupled receptor; Phosphorylation; Channelopathies
Five different profiles of dihydropyridines in blocking T-type Ca2+ channel subtypes (Cav3.1 (α1G), Cav3.2 (α1H), and Cav3.3 (α1I)) expressed in Xenopus oocytes
Keywords: کانال کلسیم T نوع; T-type calcium channel; Dihydoropyridine; Calcium antagonist; Xenopus oocyte
Structural and biophysical determinants of single CaV3.1 and CaV3.2 T-type calcium channel inhibition by N2O
Keywords: کانال کلسیم T نوع; Single-channel analysis; CaV3.1; CaV3.2; T-type calcium channel; Nitrous oxide
Tyrosine kinase-independent inhibition by genistein on spermatogenic T-type calcium channels attenuates mouse sperm motility and acrosome reaction
Keywords: کانال کلسیم T نوع; Genistein; T-type calcium channel; Spermatogenic cells; Tyrosine kinase
Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers
Keywords: کانال کلسیم T نوع; T-type calcium channel; Neuropathic pain; Patch-clamp