Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies
Keywords: Autoimmune disease; Interferonopathy; TBK1; Type I interferon; Lupus;
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TANK-binding kinase-1 broadly affects oyster immune response to bacteria and viruses
Keywords: Pacific oyster; Crassostrea gigas; TBK1; Innate immunity; STING;
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling
Keywords: BMDMs; bone marrow-derived macrophages; c-di-GMP; cyclic diguanylate monophosphate; DMEM; Dulbecco's modified Eagle's medium; ER; endoplasmic reticulum; FBS; fetal bovine serum; GST; Glutathione S-transferase; HEK293T; human embryonic kidney; IB; immunobl
TBK1 mutation frequencies in French frontotemporal dementia and amyotrophic lateral sclerosis cohorts
Keywords: TBK1; Frontotemporal dementia (FTD); Amyotrophic lateral sclerosis (ALS); Frontotemporal lobar degeneration (FTLD); Optineurin; Loss of function;
Semantic and nonfluent aphasic variants, secondarily associated with amyotrophic lateral sclerosis, are predominant frontotemporal lobar degeneration phenotypes in TBK1 carriers
Keywords: TBK1; Frontotemporal lobar degeneration; Semantic variant FTLD; Aphasic variant FTLD; Genetics; Behavioral disorders; Amyotrophic lateral sclerosis
Expression profiles and interaction suggest TBK1 can be regulated by Nrdp1 in response to immune stimulation in large yellow croaker Larimichthys crocea
Keywords: Larimichthys crocea; TBK1; Nrdp1; Protein interaction; Immune stimulation
HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression
Keywords: HTLV; Tax; IKKε; TBK1; IFN; IRF3; Cell signaling;
Functions of the two zebrafish MAVS variants are opposite in the induction of IFN1 by targeting IRF7
Keywords: MAVS variants; Negative regulator; Interferon; IRF7; Zebrafish; CARD; caspase recruiting domain; CPE; cytopathic effect; DBD; DNA binding domain; EPC; epithelioma papulosum cyprini; GBP4; guanylate binding protein 4; IFN; interferon; IKKε; IkappaB kinase
Genetic obesity alters recruitment of TANK-binding kinase 1 and AKT into hypothalamic lipid rafts domains
Keywords: TBK1; Insulin receptor; AKT; Insulin resistance; Hypothalamus and lipotoxicity; Obesity
BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest
Keywords: BX795; Oral cancer; TBK1; Cell cycle; Autophagy
Novel TBK1 truncating mutation in a familial amyotrophic lateral sclerosis patient of Chinese origin
Keywords: Amyotrophic lateral sclerosis; Motor neuron disease; TBK1; Gene; Mutation; Frameshift;
Identification of a novel MYOC mutation, p.(Trp373*), in a family with open angle glaucoma
Keywords: ANZRAG; Australian and New Zealand Registry of Advanced Glaucoma; BCVA; best corrected visual acuity; IOP; intraocular pressure; LE; left eye; mRNA; messenger RNA; MYOC; myocilin; NATA; National Association of Testing Authorities; NMD; nonsense mediated d
Discovery of 6-aryl-azabenzimidaoles that inhibit the TBK1/IKK-ε kinases
Keywords: TBK1; IKK-ε; Azabenzimidazole; Kinase inhibitor;
Toll like receptors in self-recovering hepatitis E patients with or without pregnancy
Keywords: ANC; Antenatal care (pregnancy); HEV; hepatitis E virus; TLR; Toll like receptors; IRAK; interleukin-1 receptor-associated kinase; IkBα; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NFkB; nuclear factor kappa-light
Molecular characterizations of grass carp (Ctenopharyngodon idella) TBK1 gene and its roles in regulating IFN-I pathway
Keywords: Grass carp (Ctenopharyngodon idella); TBK1; Genomic structure; Promoter activity; IFN-I pathway; Grass carp reovirus;
Human DExD/H RNA helicases: Emerging roles in stress survival regulation
Keywords: 5â²ppp; 5â² triphosphate; AMD; ARE-mediated mRNA decay; ARE; AU-rich element; ARE-BP; ARE-binding protein; CARD; caspase activation and recruitment domain; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; CDN; cyclic dinucleotide; CRM1; Chromosome Maint
Negative regulation of TBK1-mediated antiviral immunity
Keywords: Antiviral; TBK1; Interferon; Virus;
Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands
Keywords: TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat
DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication
Keywords: 5â² ppp; 5â² triphosphate; AIM2; Absent In Melanoma 2; ARE; AU-rich element; CARD; Caspase Activation and Recruitment Domains; CDN; cyclic dinucleotide; cGAMP; cyclic-GMP-AMP; cGAS; cGAMP Synthase; CRM1; Chromosome Maintenance Region 1; CstF; Cleavage S
TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by helenalin
Keywords: Toll-like receptors; Helenalin; LPS; TRIF; TBK1
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases
Keywords: TBK1; IKKε; TANK-binding kinase; IκB kinase epsilon; Interferon β; RANTES;
Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
Keywords: TBK1; IKKε; Azabenzimidazole; Kinase inhibitor;
PPM1B negatively regulates antiviral response via dephosphorylating TBK1
Keywords: PPM1B; TBK1; Phosphatase; Antiviral response;
OxLDL inhibits LPS-induced IFNβ expression by Pellino3- and IRAK1/4-dependent modification of TANK
Keywords: hMΦ; human monocyte derived macrophages; IFNβ; interferon β; IKKε; inhibitor of NFκB kinase ε; IRAK; interleukin-1 receptor-associated kinase; IRF3; interferon regulatory factor 3; IP-10; interferon-inducible protein-10; LPS; lipopolysaccharide; MAP
Transcriptional regulation of type I interferon gene expression by interferon regulatory factor-3 in Japanese flounder, Paralichthys olivaceus
Keywords: ATF2; activating transcription factor 2; BAC; bacterial artificial clone; CpG-ODN; cytosine-phosphate-guanosine oligodeoxynucleotides; dsRNA; double-strand RNA; IFN; interferon; IKKε; IκB kinase epsilon; IPS-1/MAVS/VISA/Cardif; IFN-β promoter stimulato
Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice
Keywords: ROS; reactive oxygen species; T1D; type 1 diabetes; NOD; nonobese diabetic; BM-MÏ; bone marrow-derived macrophages; MHC; major histocompatibility complex; NOX; NADPH oxidase; Ncf1; neutrophil cytosolic factor 1; TLR; Toll-like receptor; poly(I:C); polyin
Expression profiles of carp IRF-3/-7 correlate with the up-regulation of RIG-I/MAVS/TRAF3/TBK1, four pivotal molecules in RIG-I signaling pathway
Keywords: RIG-I; MAVS; TRAF3; TBK1; Common carp
ESPRIT: An automated, library-based method for mapping and soluble expression of protein domains from challenging targets
Keywords: ESPRIT; expression of soluble proteins by random incremental truncation; GFP; green fluorescent protein; TBK1; TANK-binding kinase 1; IPTG; isopropyl-beta-d-thiogalactopyranoside; TEV; tobacco etch virus; BCCP; biotin carboxyl carrier protein.; ESPRIT; NF
Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses
Keywords: Interferon; Alphavirus; PKR; MDA5; TBK1; RIG-I; Antagonism
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
Keywords: TBK1; Optineurin; Glaucoma; TNF; NEMO; IKK;
TBK1 does not play a role in the control of in vitro Burkholderia pseudomallei growth
Keywords: Melioidosis; Burkholderia pseudomallei; Brucella melitensis; Escherichia coli; tbk1; Intracellular signalling;
Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (−)-epigallocatechin-3-gallate, a polyphenol component of green tea
Keywords: TRIF, TIR domain-containing adapter inducing IFN-β; IKK, IκB kinase; TBK1, TANK-binding kinase 1; IRF3, IFN-regulatory factor 3EGCG; Flavonoid; Toll-like receptor; MyD88; TRIF; TBK1
Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses-and viruses counteract IFN action
Keywords: Interferons; Innate antiviral immunity; Interferon-regulatory factor; Toll-like receptors; AP-1; activating protein 1; CARD; caspase recruitment domain; CpG DNA; unmethylated double-stranded DNA; DC; dendritic cell; dsRNA; double-stranded RNA; GAS; IFN ga