دانلود مقالات ISI درباره Tcptp + ترجمه فارسی

ارزیابی بیوشیمیایی روشهای غربالگری مجازی نشانگر مهارکننده فعال سلولی از فسفاتازهای ترویج سرطان کبد بازسازی شده

Biochemical evaluation of virtual screening methods reveals a cell-active inhibitor of the cancer-promoting phosphatases of regenerating liver

Keywords: Dual specificity phosphatases; Virtual screening methods; Phosphatases of regenerating liver; Enzyme inhibitors; Thienopyridone; 2-Cyano-2-ene-esters; DIFMUP; 6,8-difluoro-4-methylumbelliferyl phosphate; DSP; dual specificity phosphatase; MTT; 3-(4,5-dime

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting phosphatases of regenerating liver (PRLs) in cancer

Keywords: Protein tyrosine phosphatase; Metastasis; Theinopyridone; Structure; CBS; cystathionine-beta-synthase; CHO; Chinese hamster ovary; CNNM; magnesium transporters of cyclin M; EMT; epithelial-mesenchymal transition; HMVEC; human microvascular endothelial c

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics

Keywords: SPB; structure based pharmacophore; ADMET; absorption, distribution, metabolism, excretion, and toxicity; TCPTP; T cell protein-tyrosinephosphatase; PTP1B; protein tyrosine phosphatase 1B; NS; Noonan Syndrome; JMML; juvenile myelomonocytic leukemia; AML;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

The design strategy of selective PTP1B inhibitors over TCPTP

Keywords: Selectivity; PTP1B inhibitor; TCPTP; Diabetes; Design strategy;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

The tyrosine phosphatase TC48 interacts with and inactivates the oncogenic fusion protein BCR-Abl but not cellular Abl

Keywords: Abl; Abelson; PTP; protein tyrosine phosphatase; TCPTP; T-cell PTP; CML; chronic myelogenous leukemia; BCR; break point cluster gene;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Keywords: AICAR; 5-amino-4-imidazole-carboxamideriboside; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; CRP; C-reactive protein; HP; haptoglobin; IKK; IkappaB kinase; IL-6; Interleukin-6; IL6Rα; IL-6 receptor subun

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases

Keywords: Copper complexes; Protein tyrosine phosphatases; Selective inhibitor; Schiff base; CSD; Cambridge Structural Database; ESI-MS; electrospray ionization mass spectra; Hcpmp; 4-chloro-2-((phenylimino)methyl)phenol; Hnpmp; 4-bromo-2-((phenylimino)methyl)pheno

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2013 سفارش ترجمه

A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells

Keywords: Protein tyrosine phosphatases; Yeast; Cell-based assay; TCPTP; Shp2; PEST; PTPα

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors

Keywords: Triaryl sulfonamide; pTyr mimetics; PTP1B inhibitor; TCPTP; Type 2 diabetes mellitus (T2DM); Metabolic disorders;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Redox signaling loops in the unfolded protein response

Keywords: AGR2; anterior gradient 2; ARE; antioxidant responsive element; ATF4; activating transcription factor-4; ATF6; activating transcription factor-6; ASK1; apoptosis signal-regulating kinase-1; BI-1; BAX inhibitor-1; BiP; immunoglobulin heavy chain-binding pr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors

Keywords: PTP1B; TCPTP; Diabetes; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of small interference RNA against PTP1B and TCPTP on insulin signaling pathway in mouse liver: Evidence for non-synergetic cooperation

Keywords: PTP1B; TCPTP; siRNA; Fatty acid synthase promoter; Diabetic mouse model;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases

Keywords: SFK; Src-family protein tyrosine kinases; CSK; C-terminal Src kinase; CHK; CSK-homologous kinase; SH2 and SH3 domains; Src-homology 2 and Src-homology 3 domains; YT; C-terminal tail regulatory tyrosine of SFKs; YA; autophosphorylated tyrosine in the activ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه