کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7802459 1501159 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors
چکیده انگلیسی
► Thirty-two 2-substituted ethenesulfonic acid ester derivatives were prepared. ► Most compounds exhibited excellent inhibitory activities against PTP1B with IC50 values of 1.3-15.1 μM. ► The substitution at the aromatic center and the length of linker markedly affected the inhibitory activity against PTP1B. ► Most chemicals have low cytotoxicity for COS-7 cell with IC50 values >100 μM. ► Compounds 43 and 36 marked 10- and 20-fold selectivity over TCPTP respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 57, November 2012, Pages 10-20
نویسندگان
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