دانلود مقالات ISI درباره Tdp + ترجمه فارسی

Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer

Keywords: ATR; ATM-Rad3-related; BER; base excision repair; Chk1; checkpoint kinase 1; DDR; DNA damage response and repair; DNA-PKcs; DNA-PK catalytic subunit; DOT1L; DOT1-like; DSB; double strand break; FOLFIRINOX; folinic acid, 5-FU, irinotecan, oxaliplatin; 5-FU

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Metabolomics deciphers the host resistance mechanisms in wheat cultivar Sumai-3, against trichothecene producing and non-producing isolates of Fusarium graminearum

Keywords: Deoxynivalenol; Fusarium head blight; Phenylpropanoids and flavonoids; Quantitative resistance; Sumai-3; Trichothecenes non-producing mutants (Tri5-); AUDPC; Area Under the Disease Progress Curve; C4H; Cinnamate 4-hydroxylase; CAD; Cinnamoyl alcohol dehyd

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Associations between in vivo neuroimaging and postmortem brain cytokine markers in a rodent model of Wernicke's encephalopathy

Keywords: Thiamine; TDP; Lactate; Microglia; MCP-1; Magnetic resonance imaging; Magnetic resonance spectroscopy; Immunohistochemistry; Liver; Brain;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome

Keywords: aLQTS; drug-induced or acquired long-QT syndrome; AP; action potential; APD; action potential duration; APD90; action potential duration at 90% repolarization; C1; closed state 1; C2; closed state 2; C3; closed state 3; EAD; early-afterdepolarization; ECG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

A public-private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Keywords: ADRs; adverse drug reactions; CDER; Center for Drug Evaluation and Research; cTn; cardiac troponin; CV; cardiovascular; EMA; European Medicines Agency; EWG; Expert Working Group; ECG; electrocardiogram; HESI; Health and Environmental Sciences Institute; h

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Water harvesting for young trees using Peltier modules powered by photovoltaic solar energy

Keywords: DAQB; data acquisition board; EMF; electromotive force; ETc; crop evapotranspiration; SPV; solar photovoltaic ; SPVM; solar photovoltaic module; Tdp; dew point temperature; Ts; condensing surface temperature; Hr; relative humidity; TD; temperature differ

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge

Keywords: AP (D); Action Potential (Duration); ECG; electrocardiogram; ECVAM; European Centre for the Validation of Alternative Methods; FLIPR; FLuorescence Imaging Plate Reader; GSK; GlaxoSmithKline; hERG; human-Ether-a-go-go Related Gene; IC50; Concentration for

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A history of the role of the hERG channel in cardiac risk assessment

Keywords: hERG; human ether-a-go-go-related gene; TdP; torsades de pointes; TQT; thorough QT trial; Agonists; Blockers; hERG; Methods; Modeling; Patch clamp; Trafficking;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Thiamine Deficiency in Cambodian Infants with and without Beriberi

Keywords: TDP; Thiamine diphosphate; TDP/Hct; Thiamine diphosphate divided by hematocrit;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Thiamin (vitamin B1) and thiamin phosphate esters in five cereal grains during maturation

Keywords: Grain maturation; Thiamin; Thiamin phosphate esters; HPLC; AThTP; adenosine thiamin triphosphate; C-8; stationary phase derivated with C-8 carbon units; cv; convarietas; DM; dry matter; E; East; GS; growth stage; HPLC; high-performance liquid chromatograp

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Beat-to-beat variability of repolarization as a new biomarker for proarrhythmia in vivo

Keywords: Short-term variability; Torsades de pointes; Chronic AV block dog; Drugs; Long QT syndrome; Repolarization; Biomarkers; APD; action potential duration; BVR; beat-to-beat variability of repolarization; cAVB; chronic atrioventricular block; ECG; electrocard

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Metabolic stress, reactive oxygen species, and arrhythmia

Keywords: ∆Ψm; mitochondrial membrane potential; ACE; angiotensin converting enzyme; ADP; adenosine diphosphate; AF; atrial fibrillation; AngII; angiotensin II; AP; action potential; ATP; adenosine-5′-triphosphate; [Ca2+]i; intracellular Ca2+ concentration; CI

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog

Keywords: Arrhythmias; Calcineurin; CaMKII; Chronic AV block dog; Ventricular remodeling; ANP; atrial natriuretic peptide; APD; action potential duration; CaMKII; calcium/calmodulin-dependent protein kinase II; CAVB; chronic AV block; CnA; calcineurin-A; CSA; cyc

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Heat shock protein 27 mediates the effect of 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone on mitochondrial apoptosis in hepatocellular carcinoma

Keywords: TDP; 1,3,5-trihydroxy-13,13-dimethyl-2H-pyran [7,6-b] xanthone; Garcinia oblongifolia; G. oblongifolia; Hsp27; heat shock protein 27; HCC; hepatocellular carcinoma; 2-DE; 2-dimensional electrophoresis; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Arrhythmogenic mechano-electric heterogeneity in the long-QT syndrome

Keywords: Long-QT syndrome; Electromechanical window; Calcium; Aftercontractions; Torsades de pointes; Ventricular arrhythmia; AP; action potential; APD; action-potential duration; CaMKII; Ca2+/Calmodulin-dependent serine-threonine protein kinase II; CaM; Ca2+/Calm

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Nutrient removal using biosorption activated media: Preliminary biogeochemical assessment of an innovative stormwater infiltration basin

Keywords: BAM; biosorption activated media; CEC; cation exchange capacity; DNRA; dissimilatory nitrate reduction to ammonium; DO; dissolved oxygen; DIC; dissolved inorganic carbon; DOC; dissolved organic carbon; IC; inorganic carbon; IN; inorganic nitrogen; OC; org

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Torsade de pointes induced by citalopram and amiodarone

Keywords: LQTS; TdP; Citalopram; AmiodaroneLQTS; TdP; Citalopram; Amiodarone

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers

Keywords: Electrocardiography; Ion channels; Obesity; Pharmacology; QT interval; BMI; body mass index; ECG; electrocardiogram; TdP; torsades de pointes;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

A novel mechanism for LQT3 with 2:1 block: A pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation

Keywords: Cardiac Sodium Channel; LQT3; V411M; Flecainide; Mexiletine; Lidocaine; WT; wild-type; LQTS; Long QT Syndrome; AP; action potential; ECG; electrocardiogram; GOF; gain of function; HEK; human embryonic kidney; TdP; torsades de pointes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Keywords: Alk; activin receptor-like kinase; CPSF; cleavage polyadenylation specificity complex; HD; Hirschsprung disease; MR; mental retardation; PAH; pulmonary arterial hypertension; PD; Parkinson disease; SIP; Smad-interacting protein; Smicl; Smad-interacting CP

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Role of Mg2+ block of the inward rectifier K+ current in cardiac repolarization reserve: A quantitative simulation

Keywords: AP; action potential; SPM; spermine; SPD; spermidine; APD; action potential duration; EAD; early afterdepolarization; LQTS; Long QT syndrome; TdP; torsades de pointes; Potassium channels; Action potentials; Long-QT syndrome; Arrhythmia; Computer model;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Torsades de pointes liability inter-model comparisons: The experience of the QT PRODACT initiative

Keywords: APD; action potential duration; APD90; APD at 90% repolarization; APD30-90; APD between 30% and 90% repolarization; APD30-60; APD between 30% and 60% repolarization; AV; atrioventricular; EC10; effective concentration producing 10% changes; IKr; rapid

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2008 سفارش ترجمه

If a drug deemed 'safe' in nonclinical tests subsequently prolongs QT in phase 1 studies, how can its sponsor convince regulators to allow development to proceed?

Keywords: CHMP; Committee for Medicinal Products for Human Use; COX; Cycloxygenase; ECG; Electrocardiogram; EU; European Union; FDA; Food and Drug Administration of the United States; hERG; Human ether-a-go-go related gene; ICH; International Conference on Harmoniz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis

Keywords: APD; action potential duration; ECG; electrocardiogram; hERG; human ether-a-gogo related gene; MAP; monophasic action potential; QTc; corrected QT interval on ECG; TdP; torsade de pointes; VT; ventricular tachycardia; VF; ventricular fibrillation; TRIaD;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

The canine model with chronic, complete atrio-ventricular block

Keywords: AV; Atrio-ventricular; AAVB; Acute complete atrio-ventricular block; BVR; Beat-to-beat variability of repolarization; CAVB; Chronic complete atrio-ventricular block; CAVBr; CAVB resistant to drug-induced TdP; CAVBs; CAVB susceptible to drug-induced TdP; D

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Model systems for the discovery and development of antiarrhythmic drugs

Keywords: Arrhythmias; Ion channel blockers; Ion currents; Reentry; AF; atrial fibrillation; APD; action potential duration; CAVB; chronic atrio-ventricular block; CHF; congestive heart failure; DAD; delayed afterdepolarization; EAD; early afterdepolarization; hERG

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Thermodynamic properties of enzyme-catalyzed reactions involving cytosine, uracil, thymine, and their nucleosides and nucleotides

Keywords: CTP; cytidine triphosphate; CDP; cytidine diphosphate; CMP; cytidine monophosphate; UTP; uridine triphosphate; UDP; uridine diphosphate; UMP; uridine monophosphate; TTP; thymidine triphosphate; TDP; thymidine diphosphate; CMP; thymidine monophosphate.; Cy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

DNA topoisomerase I from parasitic protozoa: A potential target for chemotherapy

Keywords: LdTOPIA, gene encoding the large subunit of L donovani topoisomerase I; LdTOPIB, gene encoding the small subunit of L donovani topoisomerase; PfTOPI, gene encoding P. falciparum topoisomerase I; NLS, nuclear localization signal; kDNA, kinetoplast DNA; Tdp

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias

Keywords: AP; action potential; IC50; concentration at 50% inhibition; TdP; torsades de pointes; Ventricular arrhythmias; Guidelines; IKr; Drug effects; QT prolongation; Repolarisation;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2006 سفارش ترجمه

The analysis of thiamin and its derivatives in whole blood samples under high pH conditions of the mobile phase

Keywords: Thiamin; Vitamin B1; HPLC; Whole blood analysis; High pH mobile phase; TDP; thiamin diphosphate; TMP; thiamin monophosphate; QC; quality control; RP; reversed-phase; TEA; triethylamin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Drugs effects on ventricular repolarization: A critical evaluation of the strengths and weaknesses of current methodologies and regulatory practices

Keywords: Ventricular repolarization; Potassium ion conductance; TdP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs

Keywords: Anesthetized; EAD; Dofetilide; Dog; Instability; LQT; Poincaré plot; QT; TdP; Variability;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Nonclinical proarrhythmia models: Predicting Torsades de Pointes

Keywords: AP; Action potential; APD; Action potential duration; APD90; Action potential duration at 90% repolarization; A-V; Atrioventricular; CAVB; Chronically A-V block; CV; Conduction velocity; EADs; Early after-depolarizations; ECG; Electrocardiogram; hERG; Hum

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه