دانلود مقالات ISI درباره tetrahydroisoquinoline + ترجمه فارسی

تشخیص و درمان آنافیلاکسی در پزشکی دقیق

Diagnosis and management of anaphylaxis in precision medicine

Keywords: tetrahydroisoquinoline; Anaphylaxis; adverse drug reactions; drug hypersensitivity reactions; hypersensitivity reactions; IgE; mAbs; ACE; Angiotensin-converting enzyme; ED; Emergency department; FTEIA; Food-triggered exercised-induced anaphylaxis; THIQ; Tetrahydroisoquinoline;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

کنترل میتوکندریال بیومارکرهای سلولی در بیماری پارکینسون

Mitochondrial control of cell bioenergetics in Parkinson's disease

Keywords: tetrahydroisoquinoline; 6-OHDA; 6-hydroxydopamine; ADTIQ; 1-acetyl-6, 7-dihydroxyl-1, 2, 3, 4-tetrahydroisoquinoline; AMPK; 5′-AMP-activated protein kinase; ATF; activating transcription factor 6; ATM; ataxia telangiectasia mutated; CHOP; CCAAT/-enhancer-binding protein homolo

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

سنتز و اتصال مولکولی سولفونامید های 1،2،3-تریاازول به عنوان مهار کننده های آروماتاز

Synthesis and molecular docking of 1,2,3-triazole-based sulfonamides as aromatase inhibitors

Keywords: tetrahydroisoquinoline; Triazole; Sulfonamide; Tetrahydroisoquinoline; Anti-aromatase activity; Structure-activity relationships; Molecular docking;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Lewis acid-catalyzed Friedel-Crafts/Michael cascade reaction of N,N-dialkyl-3-vinylanilines with N-tosylaziridines for the stereoselective synthesis of highly functionalized tetrahydroisoquinolines

Keywords: tetrahydroisoquinoline; Friedel-Crafts reaction; Michael addition; Cascade reaction; Tetrahydroisoquinoline; N-Tosylaziridine;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2018 سفارش ترجمه

Redox-neutral C-H cyanation of tetrahydroisoquinolines under photoredox catalysis

Keywords: tetrahydroisoquinoline; Cyanation; C-H functionalization; Redox-neutral; Photoredox catalysis; Tetrahydroisoquinoline;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2018 سفارش ترجمه

Photocatalytic oxidative cyclization of α-halo hydrazones with tetrahydroisoquinoline for construction of isoquino[3,4-a][1,2,4]-triazines

Keywords: tetrahydroisoquinoline; Photocatalysis; Oxidative cyclization; α-Halogeno hydrazine; Tetrahydroisoquinoline; Isoquino[3,4-a][1,2,4]-triazine;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Lewis acid-catalyzed [3+3] cycloadditions of donor‒acceptor aziridines with N,N-dialkyl-3-vinylanilines via carbon-carbon bond cleavage

Keywords: tetrahydroisoquinoline; Cycloaddition; Aziridine; Tetrahydroisoquinoline; Friedel-Crafts reaction; Michael addition;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives

Keywords: tetrahydroisoquinoline; RORγt; retinoic acid receptor-related orphan receptor-gamma t; EAE; experimental autoimmune encephalomyelitis; BODIPY; boron-dipyrromethene; TR-FRET; time-resolved fluorescence resonance energy transfer; SAR; structure-activity relationship; IFN-γ; inte

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors

Keywords: tetrahydroisoquinoline; Synthesis; Tetrahydroquinoline; Tetrahydroisoquinoline; PDE4B inhibitor; Molecular simulation;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Synthesis and activity of benzopiperidine, benzopyridine and phenyl piperazine based compounds against Leishmania infantum

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Tetrahydroquinoline; Schiff base; Splenocytes; Cytotoxicity; Amphotericin B;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Ability of higenamine and related compounds to enhance glucose uptake in L6 cells

Keywords: tetrahydroisoquinoline; β2-Adrenergic receptor; Tetrahydroisoquinoline; Glucose uptake; Muscle cell; Diabetes;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase

Keywords: tetrahydroisoquinoline; OP; organophosphate; hAChE; human acetylcholinesterase; ACh; acetylcholine; 2-PAM; pralidoxime; MINA; monoisonitrosoacetone; BBB; bloodbrain barrier; CNS; central nervous system; P-site; peripheral anionic site; PSL; peripheral site ligand; TIQ; tetrahydr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

PIFA-BF3·OEt2 mediated intramolecular regioselective domino cyclization of ynamides: A novel method for the synthesis of tetrahydroisoquinoline-oxazol-2(3H)-ones

Keywords: tetrahydroisoquinoline; Ynamide; Hypervalent iodine; Domino cyclization; Tetrahydroisoquinoline; Oxazol-2(3H)-one;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Enantioselective cross dehydrogenative coupling reaction catalyzed by Rose Bengal incorporated-Cu(I)-dimeric chiral complexes

Keywords: tetrahydroisoquinoline; Cross dehydrogenative coupling; Tetrahydroisoquinoline; Schiff bases; Photo redox; Visible light; Alkynylation;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer

Keywords: tetrahydroisoquinoline; Histone deacetylases inhibitor; Anticancer; Tetrahydroisoquinoline; Structure–activity relationship

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibitors of HIV-1 attachment: The discovery and structure–activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore

Keywords: tetrahydroisoquinoline; HIV-1; Entry; Attachment; Tetrahydroisoquinoline; Tetrahydropyrido[3,4-d]pyrimidines; BMS-663068

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline-C-aryl glucosides; SGLT2 inhibitors; Type 2 diabetes; Tetrahydroisoquinoline

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids

Keywords: tetrahydroisoquinoline; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); 1-methyl-4-phenylpyridinium cation (MPP+); Paraquat; β-carboline; Tetrahydroisoquinoline; Neurotoxins; Neuroprotectants; Parkinson's disease; BBB; blood-brain barrier; βCs; β-carbolines; βC+s; β-ca

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from α-hydroxy-β-amino esters

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; α-Hydroxy-β-amino ester; Aziridinium; Asymmetric synthesis;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2016 سفارش ترجمه

Selective N-alkylation of isoquinolines, benzazepines and thienopyridines with aromatic aldehydes and naphthols

Keywords: tetrahydroisoquinoline; Mannich reaction; Aminonaphthol; Tetrahydroisoquinoline; N-alkylation; α-Functionalization;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

A newly discovered neurotoxin ADTIQ associated with hyperglycemia and Parkinson's disease

Keywords: tetrahydroisoquinoline; 1-Acetyl-6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline (ADTIQ); Diabetes; Parkinson's disease (PD); Methylglyoxal; ADTIQ; 1-acetyl-6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Salsolinol; 1-methyl-4-ph

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Highly selective partial dehydrogenation of tetrahydroisoquinolines using modified Pd/C

Keywords: tetrahydroisoquinoline; Palladium on carbon; Partial dehydrogenation; Tetrahydroisoquinoline; Imine; Dehydroaromatization

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

C1-alkynylation of tetrahydroisoquinoline by A3 reaction using metal-organic framework Cu2(BPDC)2(BPY) as an efficient heterogeneous catalyst

Keywords: tetrahydroisoquinoline; Metal-organic framework; Tetrahydroisoquinoline; Alkynylation; A3 reaction; Heterogeneous catalyst

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Mechanically activated ring-opening reactions of N-acyl-1,2,3,4-tetrahydroisoquinolines derived from the synthesis of praziquantel intermediate

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Ring-opening reaction; Praziquantel; Ball milling;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif

Keywords: tetrahydroisoquinoline; Kappa opioid receptor; Antagonist; Molecular constraint; Potency enhancement; Tetrahydroisoquinoline

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor

Keywords: tetrahydroisoquinoline; MGAT2; monoacylglycerol acyltransferase 2; TG; triglyceride; FeSSIF; Fed State Simulated intestinal Fluid; MS; metabolic stability; TFAA; trifluoroacetic anhydride; EDC·HCl; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; HOBt·H2O; 1-hydrox

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor

Keywords: tetrahydroisoquinoline; BOP; (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; HATU; 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate; HPLC; high performance liquid chromatography; OX1; orexin 1 receptor; OX2;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Scandium(III) triflate mediated intramolecular ring expansion of aziridines: a direct access to 4-aryltetrahydroisoquinolines

Keywords: tetrahydroisoquinoline; Intramolecular; Ring expansion; Aziridine; Tetrahydroisoquinoline; Scandium(III) triflate;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

A facile one-pot protocol for the synthesis of tetrazolyl-tetrahydroisoquinolines via novel domino intramolecular cyclization/Ugi-azide sequence

Keywords: tetrahydroisoquinoline; Tetrazole; Tetrahydroisoquinoline; Ugi-azide; One-pot transformation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Design and synthesis of D1 agonist/D2 antagonist for treatment of schizophrenia

Keywords: tetrahydroisoquinoline; D1 receptor (D1R) agonist and D2 receptor (D2R) antagonist; Tetrahydroisoquinoline; Schizophrenia; Nature product lead; SAR and lead optimization;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Efficient 'one-pot' methodology for the synthesis of novel tetrahydro-β-carboline, tetrahydroisoquinoline and tetrahydrothienopyridine derivatives

Keywords: tetrahydroisoquinoline; Tetrahydro-β-carbolines; N-Carbamyliminium; Pictet-Spengler; Tetrahydroisoquinoline; Tetrahydrothienopyridine;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, physicochemical characterization, cytotoxicity, antimicrobial, anti-inflammatory and psychotropic activity of new N-[1,3-(benzo)thiazol-2-yl]-ω-[3,4-dihydroisoquinolin-2(1H)-yl]alkanamides

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Thiazole; Cytotoxicity; Psychotropic activity; Anti-inflammatory activity; Antimicrobial activity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

Keywords: tetrahydroisoquinoline; Anticancer; Tetrahydroisoquinoline; RutheniumA549, human lung epithelial adenocarcinoma; atm, atmosphere; ATR, attenuated total reflectance; Cbz-Cl, benzyl chloroformate; DIPEA, N,N-diisopropylethylamine; DBU, 1,8- diazabicycloundec-7-ene; ESI-QTOF, elect

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Total synthesis and cytotoxicity of (−)-jorumycin and its analogues

Keywords: tetrahydroisoquinoline; (−)-Jorumycin; Tetrahydroisoquinoline; Synthesis; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Asymmetric synthesis and cytotoxicity of (−)-saframycin A analogues

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; (−)-Saframycin A; Cytotoxicity; Synthesis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide

Keywords: tetrahydroisoquinoline; Renieramycin; Tetrahydroisoquinoline; Isolation; Marine natural product; Structure elucidation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Selective trifluoromethylation and alkynylation of tetrahydroisoquinolines using visible light irradiation by Rose Bengal

Keywords: tetrahydroisoquinoline; Photooxidation; Visible light; Trifluoromethylation; Alkynylation; Trimethyl(trifluoromethyl)silane; Tetrahydroisoquinoline

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Chiral aziridine-2-carboxylates: versatile precursors for functionalized tetrahydroisoquinoline (THIQ) containing heterocycles

Keywords: tetrahydroisoquinoline; Chiral aziridine; Modified Bischler-Napieralski cyclization; Stereoselective reduction; Tetrahydroisoquinoline;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Keywords: tetrahydroisoquinoline; LFA-1/ICAM-1 antagonist; Tetrahydroisoquinoline; α-Amino acid; Structure-activity relationship; (S)-2,3-Diaminopropanoic acid replacement;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents

Keywords: tetrahydroisoquinoline; Multidrug resistance; Anticancer; Tetrahydroisoquinoline; Nitric oxide

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Chiral capillary electrophoresis–mass spectrometry of tetrahydroisoquinoline-derived neurotoxins: Observation of complex stereoisomerism

Keywords: tetrahydroisoquinoline; Chiral capillary electrophoresis; Mass spectrometry; Neurotoxin; Tetrahydroisoquinoline; N-methylsalsolinol; Stereoisomer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Enantioselective synthesis of 1-vinyltetrahydroisoquinolines via Pd-catalyzed intramolecular asymmetric allylic amination reactions

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Asymmetric allylic amination; Palladium; Phosphoramidite ligand; Phosphonite ligand;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Anti-thrombotic activity; Vasorelaxation

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

o-Benzenedisulfonimide as a reusable acid catalyst for an easy, efficient, and green synthesis of tetrahydroisoquinolines and tetrahydro-β-carbolines through Pictet-Spengler reaction

Keywords: tetrahydroisoquinoline; Homogeneous catalysis; Tetrahydroisoquinoline; Tetrahydro-β-carbolines; Brønsted acid; 2-Arylethanamines;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of novel tetrahydroisoquinoline bronchodilators

Keywords: tetrahydroisoquinoline; Asthma; COPD; Bronchodilator; Tetrahydroisoquinoline; Palladium catalyzed cross-coupling

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Bis-tetrahydroisoquinoline derivatives: Structure analysis of the three stereoisomers of 1,1′-(propane-1,3-diyl)-bis-(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline)

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Potassium channel blockers; Absolute configuration; Crystal structure;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Facile synthesis of octahydrobenzo[h]isoquinolines: Novel and highly potent D1 dopamine agonists

Keywords: tetrahydroisoquinoline; Dopamine agonist; Tetrahydroisoquinoline; Conjugate addition; Oxazoline;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

2,3-Diamino acid modifying 3S-tetrahydroisoquinoline-3-carboxylic acids: Leading to a class of novel agents with highly unfolded conformation, selective in vitro anti-platelet aggregation and potent in vivo anti-thrombotic activity

Keywords: tetrahydroisoquinoline; Tetrahydroisoquinoline; Modification; Anti-thrombotic; Conformation; 3D QSAR

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of new chiral 1,2,3,4-tertrahydroisoquinoline β-amino alcohol for asymmetric diethylzinc addition to aryl aldehydes (I)

Keywords: tetrahydroisoquinoline; β-Amino alcohol; Tetrahydroisoquinoline; Diethylzinc; Asymmetric addition;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Fast, solvent-free asymmetric alkynylation of prochiral sp3 C-H bonds in a ball mill for the preparation of optically active tetrahydroisoquinoline derivatives

Keywords: tetrahydroisoquinoline; Asymmetric synthesis; Ball mill; Cross-coupling; C-H activation; Tetrahydroisoquinoline;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه