Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists

Structure-activity relationship (SAR) of the α-amino acid residue and identification of (S)-2,3-diaminopropanoic acid (DAP) replacements of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists are described.