Keywords: پروتئین های درمانی; high-throughput dynamic light scattering; therapeutic proteins; in-use stability; stress stability; algorithm; quality control; aggregates; particulates; particles;
مقالات ISI پروتئین های درمانی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: پروتئین های درمانی; Lymphatic; Biologic; Therapeutic proteins; Pharmacokinetics; Biodistribution; Intravenous; Trastuzumab; Interferon; Pegylated interferon; IFN-PEG40; 60 kDa Pegylated interferon α2a, PEGASYS®; IFN-PEG12;  ~ 31 kDa Pegylated interferon α2b, PEG-Intro
Keywords: پروتئین های درمانی; Ionic liquids; Therapeutic proteins; Lysozyme; Drug delivery systems; Fluorinated surfactants;
Keywords: پروتئین های درمانی; physiologically based pharmacokinetic modelling; PBPK; monoclonal antibody; therapeutic proteins;
Keywords: پروتئین های درمانی; Model-based design; High throughput experiments; Design space determination; Therapeutic proteins; Ion exchange chromatography
Keywords: پروتئین های درمانی; Immunogenicity; Therapeutic proteins; Neutralizing antibodies; Quantitation; Neutralizing capacity;
Keywords: پروتئین های درمانی; Glioma; Glioblastoma; Alginate; Drug delivery; Liposome; Micelle; Nanoparticle; Microencapsulation; Therapeutic proteins
Keywords: پروتئین های درمانی; Size exclusion chromatography; Therapeutic proteins; Aggregates; Biopharmaceuticals
Keywords: پروتئین های درمانی; Oxidation analysis; Therapeutic proteins; Water-soluble raw materials composed of tween; Indirect potentiometry; LC–MS
An ICP-MS platform for metal content assessment of cell culture media and evaluation of spikes in metal concentration on the quality of an IgG3:κ monoclonal antibody during production
Keywords: پروتئین های درمانی; Parallel bioreactors; Chemically defined medium; CHO cells; Hybridoma-cells; Therapeutic proteins; Glycosylation;
What NMR can do in the biopharmaceutical industry
Keywords: پروتئین های درمانی; NMR; Biopharmaceutics; Therapeutic proteins; Higher order structure; Biosimilarity; Bioanalytics;
Orthogonal liquid chromatography-mass spectrometry methods for the comprehensive characterization of therapeutic glycoproteins, from released glycans to intact protein level
Keywords: پروتئین های درمانی; High-resolution mass spectrometry; Hydrophilic interaction chromatography; Mixed-mode chromatography; Porous graphitic carbon chromatography; Protein glycosylation; Therapeutic proteins;
Development, validation, and application of ELISA for detection of anti-HD105 antibodies in pre-clinical safety evaluation using monkeys
Keywords: پروتئین های درمانی; Immunogenicity; Anti-drug antibody; Therapeutic proteins; Preclinical study; Validation; Bispecific antibody;
The flexibility of a generic LC-MS/MS method for the quantitative analysis of therapeutic proteins based on human immunoglobulin G and related constructs in animal studies
Keywords: پروتئین های درمانی; Generic peptide; Therapeutic proteins; Pellet digestion; Pre-clinical species; Liquid chromatography tandem mass spectrometry;
Co-delivery of chemotherapeutics and proteins for synergistic therapy
Keywords: پروتئین های درمانی; Combination therapy; Chemotherapy; Therapeutic proteins; Synergistic effects; Cancer treatment
Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule
Keywords: پروتئین های درمانی; therapeutic proteins; protein oxidation; methionine; tryptophan; mass spectrometry; protein A binding
Fc fusion as a platform technology: potential for modulating immunogenicity
Keywords: پروتئین های درمانی; therapeutic proteins; Fc-fusion technology; immunogenicity; neutralizing antidrug antibodies; Fc receptors; drug development
Systematic evaluation of mobile phase additives for the LC–MS characterization of therapeutic proteins
Keywords: پروتئین های درمانی; TFA; Formate buffer; RPLC–MS; Therapeutic proteins; Monoclonal antibody
Characterization of Submicron (0.1-1 μm) Particles in Therapeutic Proteins by Nanoparticle Tracking Analysis
Keywords: پروتئین های درمانی; nanoparticle analysis; therapeutic proteins; aggregation; heat; agitation; UV exposure;
Microfluidics-assisted engineering of polymeric microcapsules with high encapsulation efficiency for protein drug delivery
Keywords: پروتئین های درمانی; Ethyl acetate (PubChem CID 8857); Polycaprolactone (PubChem CID 10401); Polyethylene glycol (PubChem CID 174); Poly(vinyl alcohol) (PubChem CID 11199); Microcapsules; Polycaprolactone; Microfluidics; Therapeutic proteins; Drug delivery;
CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion
Keywords: پروتئین های درمانی; CHO cells; Metabolic engineering; Protein secretion; Therapeutic proteins; Immunoglobulins;
Are Hepatic Impairment Studies Necessary for Therapeutic Proteins?
Keywords: پروتئین های درمانی; hepatic impairment; pharmacokinetics; therapeutic proteins
Establishment of a triple co-culture in vitro cell models to study intestinal absorption of peptide drugs
Keywords: پروتئین های درمانی; In vitro model; Caco-2 cells; Co-culture; Intestinal absorption; Therapeutic proteins; Nanoparticles
Rational development and utilization of antibody-based therapeutic proteins in pediatrics
Keywords: پروتئین های درمانی; Therapeutic proteins; Monoclonal antibodies; Pediatric; Pharmacokinetics; Pharmacodynamics; Dose optimization; Rational therapy; Tumor necrosis factor-alpha; InfliximabAE, adverse event; ACR, American College of Rheumatology; ADA, anti-drug antibodies; AU
Nondestructive Detection of Glass Vial Inner Surface Morphology with Differential Interference Contrast Microscopy
Keywords: پروتئین های درمانی; Differential interference contrast microscope; surface chemistry; morphology; imaging method; therapeutic proteins; microparticles; glass delamination; glass particle;
Protein Instability and Immunogenicity: Roadblocks to Clinical Application of Injectable Protein Delivery Systems for Sustained Release
Keywords: پروتئین های درمانی; drug delivery systems; immunogenicity; liposomes; physicochemical characterization; PLGA; polymers; protein delivery; stability; therapeutic proteins;
New trends in reversed-phase liquid chromatographic separations of therapeutic peptides and proteins: Theory and applications
Keywords: پروتئین های درمانی; Biopharmaceuticals; Core–shell; UHPLC; Therapeutic peptides; Therapeutic proteins
Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery
Keywords: پروتئین های درمانی; Combined cancer therapy; Photodynamic therapy; Cytostatics; Targeted drug delivery; Therapeutic proteins;
Probing the mechanism of insulin aggregation during agitation
Keywords: پروتئین های درمانی; Agitation; Insulin; Protein aggregation; Therapeutic proteins
Measuring low levels of protein aggregation by sedimentation velocity
Keywords: پروتئین های درمانی; Sedimentation velocity; Analytical ultracentrifugation; Protein aggregation; Aggregate quantitation; Therapeutic proteins; Method precision
Addressing new analytical challenges in protein formulation development
Keywords: پروتئین های درمانی; Therapeutic proteins; Formulation; Spectroscopic methods; Phase separation; Flow cytometry; Analytical ultracentrifugation
Biosimilares: balance de eficacia, seguridad y coste
Keywords: پروتئین های درمانی; Biosimilar; BiotecnologÃa; ProteÃnas terapéuticas; Biosimilar; Biotechnology; Therapeutic proteins;
Production of highly pure human glycosylated GDNF in a mammalian cell line
Keywords: پروتئین های درمانی; Therapeutic proteins; Purification of proteins; Glycosylated proteins; GDNF; Neurotrophic factors; Parkinson's disease
Production of heterologous proteins in plants: Strategies for optimal expression
Keywords: پروتئین های درمانی; Heterologous proteins; Plant expression systems; Protein production; Protein accumulation; Therapeutic proteins
Immuno-PCR assays for immunogenicity testing
Keywords: پروتئین های درمانی; Anti-drug antibody (ADA); Drug tolerance; Immuno-PCR; Immunogenicity; Neutralizing antibody; Therapeutic proteins
Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins
Keywords: پروتئین های درمانی; Multi-factorial experimental design; Immunoassay; Method validation; Method optimization; Therapeutic proteins
Increasing the sialylation of therapeutic glycoproteins: The potential of the sialic acid biosynthetic pathway
Keywords: پروتئین های درمانی; sialic acid; recombinant glycoproteins; therapeutic proteins; protein stability;
Pharmaceutical applications of isoelectric focusing on microchip with imaged UV detection
Keywords: پروتئین های درمانی; Isoelectric focusing; Microfluidics; Whole-column imaging; Therapeutic proteins; cIEF
CNTO 530: Molecular pharmacology in human UT-7EPO cells and pharmacokinetics and pharmacodynamics in mice
Keywords: پروتئین های درمانی; Recombinant proteins; Fusion proteins; Therapeutic proteins; Cytometry; Erythropoiesis; Drug effects
Disulfide bridge based PEGylation of proteins
Keywords: پروتئین های درمانی; Site-specific; PEGylation; Protein disulfide bonds; Therapeutic proteins
Glycosylation profiling of a therapeutic recombinant monoclonal antibody with two N-linked glycosylation sites using liquid chromatography coupled to a hybrid quadrupole time-of-flight mass spectrometer
Keywords: پروتئین های درمانی; Glycosylation; LC–MS; Mass spectrometry; Monoclonal antibody; Therapeutic proteins
Where disease pathogenesis meets protein formulation: Renal deposition of immunoglobulin aggregates
Keywords: پروتئین های درمانی; Immunoglobulin; Aggregation; Disease; Formulation; Therapeutic proteins; AmyloidC3, complement component 3; CDR, complementarity-determining region; COS-1, African green monkey kidney cells; DTT, dithiothreitol; FcαR, Fc receptor for IgA; IgA, immunoglobu
An acid dissociation bridging ELISA for detection of antibodies directed against therapeutic proteins in the presence of antigen
Keywords: پروتئین های درمانی; ELISA; Enzyme-Linked Immunosorbent Assay; OPD; O-phenylenediamine; PNHS; pooled normal human serum; HRP; horseradish peroxidase; OD; optical density; S/N; signal to noise; Antibody assay; Acid dissociation; Therapeutic proteins; ELISA; Antigen interferenc
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
Keywords: پروتئین های درمانی; Arg-Gly-Asp; RGD; Endothelial cells; Angiogenesis; Antivascular therapies; Cancer; Drug delivery; Gene delivery; Therapeutic proteins; Polymers; Cytostatic drugs; Radiotracer;