Keywords: TKI، مهار کننده تیروزین کیناز; TKI, tyrosine kinase inhibitor; RTK, receptor tyrosine kinase; NRVM, neonatal rat ventricular myocyte; LVID;s, left ventricular interior diameter during systole; LV Vol;s, left ventricular volume during systoleGenistein; Sunitinib; Tyrosine kinase inhibit
مقالات ISI TKI، مهار کننده تیروزین کیناز (ترجمه نشده)
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Keywords: TKI، مهار کننده تیروزین کیناز; GIST, gastrointestinal stromal tumor; HPF, high-powered field; HR, hazard ratio; IQR, interquartile range; OS, overall survival; RFS, recurrence-free survival; TKI, tyrosine kinase inhibitor
Keywords: TKI، مهار کننده تیروزین کیناز; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; NSCLC, non-small cell lung cancer; LM, leptomeningeal metastasis; CSF, cerebrospinal fluid; PCR, polymerase chain reaction; TTF, time to treatment failure; CNS, central nervous system
Liquid chromatography–tandem mass spectrometric assay for the T790M mutant EGFR inhibitor osimertinib (AZD9291) in human plasma
Keywords: TKI، مهار کننده تیروزین کیناز; TKI, tyrosine kinase inhibitor; EGFR-TK, epidermal growth factor receptor-tyrosine kinase; IS, internal standard; LC–MS/MS, liquid chromatography–tandem mass spectrometry; LLE, liquid–liquid extraction; NSCLC, non-small cell lung carcinoma; PP, protein pr
Simultaneous determination of gefitinib and its major metabolites in mouse plasma by HPLC–MS/MS and its application to a pharmacokinetics study
Keywords: TKI، مهار کننده تیروزین کیناز; TKI, tyrosine kinase inhibitor; NSCLC, non-small cell lung cancer; LC–MS/MS, liquid chromatography–tandem mass spectrometry; EGFR, epidermal growth factor receptor; MRM, multiple reaction monitoring; CYP, cytochrome P-450; PK, pharmacokinetic; ESI, electr
Cyclosporine A sensitizes human non-small cell lung cancer cells to gefitinib through inhibition of STAT3
Keywords: TKI، مهار کننده تیروزین کیناز; Cyclosporine A; EGFR–TKI; Lung cancer; STAT3NSCLC, non-small cell lung cancer; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; STAT3, signal transducer and activator of transcription 3; CsA, cyclosporine A; CypA, cyclophilin A; MDR
P-glycoprotein Mediates Ceritinib Resistance in Anaplastic Lymphoma Kinase-rearranged Non-small Cell Lung Cancer
Keywords: TKI، مهار کننده تیروزین کیناز; ALK, anaplastic lymphoma kinase; TKI, tyrosine kinase inhibitor; P-gp, P-glycoprotein; ROS1, v-ros avian ur2 sarcoma virus oncogene homolog 1; PFS, progression-free survival; ORR, overall response rate; EGFR, epidermal growth factor receptor; BBB, blood–b
Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia
Keywords: TKI، مهار کننده تیروزین کیناز; Fatty-acid derivative; Autophagy; Bcr-abl; Cell death; Warburg effectCML, chronic myeloid leukemia; mTOR, mammalian target of rapamycin; TKI, tyrosine kinase inhibitor; hnRNP, heterogenous nuclear ribonucleoprotein; PKM, pyruvate kinase M; STAT3, signalin
Functional role of the Ca2+-activated Cl− channel DOG1/TMEM16A in gastrointestinal stromal tumor cells
Keywords: TKI، مهار کننده تیروزین کیناز; GIST, Gastrointestinal stromal tumor; DOG1, Discovered on GIST-1; TKI, Tyrosine kinase inhibitor; PDGFR, Platelet-derived growth factor receptor.Gastrointestinal stromal tumor; GIST; DOG1; TMEM16A; Proliferation; Viability
Overexpression of ATP-binding cassette transporter ABCG2 as a potential mechanism of acquired resistance to vemurafenib in BRAF(V600E) mutant cancer cells
Keywords: TKI، مهار کننده تیروزین کیناز; MDR, multidrug resistance; ABC, ATP-binding cassette; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; PBS, phosphate-buffered saline; FTC, Fumitremorgin C; IAAP, Iodoarylazidoprazosin; MTT, 3-(4,5-dimethylthiazol-yl)-2,5-diphenylla
Up-regulation of FXR isoforms is not required for stimulation of the expression of genes involved in the lack of response of colon cancer to chemotherapy
Keywords: TKI، مهار کننده تیروزین کیناز; CDDP, cis-diamminedichloroplatinum(II); CRAC, colorectal adenocarcinoma; 5-FU, 5-fluorouracil; FXR, farnesoid X receptor; MDR, multidrug resistance; MOC, mechanism of chemoresistance; TKI, tyrosine kinase inhibitor; TLDA, Taqman Low-Density ArrayChemoresi
Switching addictions between HER2 and FGFR2 in HER2-positive breast tumor cells: FGFR2 as a potential target for salvage after lapatinib failure
Keywords: TKI، مهار کننده تیروزین کیناز; FGFR2, fibroblast growth factor receptor 2; HER2, human epidermal growth factor receptor 2; TKI, tyrosine kinase inhibitor; EGFR, epidermal growth factor receptor; IC50, median inhibitory concentration; siRNA, small interfering RNA; Erk, extracellular sig
Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR–TKI for adenocarcinoma of the lung
Keywords: TKI، مهار کننده تیروزین کیناز; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; ER, estrogen receptor; PFS, progression-free survival; PS, performance status; RECIST, response evaluation criteria in solid tumors; OS, overall survival; IHC, immunohistochemical; p-
Phase I study of icotinib hydrochloride (BPI-2009H), an oral EGFR tyrosine kinase inhibitor, in patients with advanced NSCLC and other solid tumors
Keywords: TKI، مهار کننده تیروزین کیناز; PK, pharmacokinetic; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; NSCLC, non-small cell lung cancer; ECOG, Eastern Cooperative Oncology Group; PS, performance status; RECIST, Response Evaluation Criteria in Solid Tumors; Q8H, ev
Mechanisms of acquired resistance to tyrosine kinase inhibitors
Keywords: TKI، مهار کننده تیروزین کیناز; TK, tyrosine kinase; TKI, tyrosine kinase inhibitor; ABC transporter, ATP-binding cassette transporter; FDA, food and drug administration; RTK, receptor tyrosine kinase; NRTK, non- receptor tyrosine kinase; EGFR, epidermal growth factor receptor; FLT3, Fm
Blockade of the ERK or PI3K–Akt signaling pathway enhances the cytotoxicity of histone deacetylase inhibitors in tumor cells resistant to gefitinib or imatinib
Keywords: TKI، مهار کننده تیروزین کیناز; EGFR, epidermal growth factor receptor; CML, chronic myeloid leukemia; NSCLC, non-small cell lung cancer; TKI, tyrosine kinase inhibitor; ERK, extracellular signal-regulated kinase; PI3K, phosphatidylinositol 3-kinase; HDAC, histone deacetylase; ROS, reac
Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status
Keywords: TKI، مهار کننده تیروزین کیناز; NSCLC, non-small cell lung cancer; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease; TTP, time to progression; IHC, immunohistochemical; T790M,
Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance
Keywords: TKI، مهار کننده تیروزین کیناز; TKI, tyrosine kinase inhibitor; EGFR, epidermal growth factor receptor; MDR, multidrug resistance; ABC, ATP-binding cassette; P-gp (ABCB1), P-glycoprotein; ABCG2, also called BCRP (breast cancer resistance protein)/MXR (mitoxantrone resistance protein); M
Gender-related disparities in non-small cell lung cancer
Keywords: TKI، مهار کننده تیروزین کیناز; HPV, Human Papillomavirus; ER, Estrogen Receptor; SERD, Selective Estrogen Receptor Down-regulator; EGF, Epidermal Growth Factor; EGFR, Epidermal Growth Factor Receptor; TKI, Tyrosine Kinase Inhibitor; mTOR, mammalian Target Of RapamycinCancer; Gender; No
Reversibility of Left Ventricular Dysfunction Resulting from Chemotherapy: Can This Be Expected?
Keywords: TKI، مهار کننده تیروزین کیناز; ACEi, angiotensin-converting enzyme inhibitor; ATP, adenosine triphosphate; BNP, brain natriuretic peptide; HF, heart failure; LVEF, left ventricular ejection fraction; PDGFR, platelet-derived growth factor receptor; TKI, tyrosine kinase inhibitor; VEGF,
Downregulation of EGFR by a novel multivalent nanobody-liposome platform
Keywords: TKI، مهار کننده تیروزین کیناز; VHH, variable domain of the heavy chain of a heavy chain antibody; mAb, monoclonal antibody; EGFR, epidermal growth factor receptor; Fab, antigen-binding fragment; scFv, single chain variable fragment; TKI, tyrosine kinase inhibitor; PEG, polyethylene gly
Kinases as targets in the treatment of solid tumors
Keywords: TKI، مهار کننده تیروزین کیناز; SMI, Small molecule inhibitor; SCLC, Small cell lung cancer; SCC, Squamous cell carcinoma; TKI, Tyrosine kinase inhibitor; GEJ, Gastro esophageal junction; IGF-1R, Insulin-like growth factor receptor; HCC, Hepatocellular carcinoma; CRC, Colorectal cancer;
Bisphosphonate zoledronic acid enhances the inhibitory effects of gefitinib on EGFR-mutated non-small cell lung carcinoma cells
Keywords: TKI، مهار کننده تیروزین کیناز; ApppI, triphosphoric acid 1-adenosin-5′-yl ester 3-(3-methylbut-3-enyl) ester; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; FPP, farnesyl diphosphate; TKI, tyrosine kinase inhibitor; IL, interleukin; VEGF, vascular endothelial gro
A potential role for imatinib and other small molecule tyrosine kinase inhibitors in the treatment of systemic and localized sclerosis
Keywords: TKI، مهار کننده تیروزین کیناز; FDA, Food and Drug Administration; HES, hypereosinophilic syndrome; PDGF, platelet-derived growth factor; PDGFR, platelet-derived growth factor receptor; SS, systemic sclerosis; TGF, tumor growth factor; TK, tyrosine kinase; TKI, tyrosine kinase inhibitor
Assessment of Epidermal Growth Factor Receptor Mutation by Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Keywords: TKI، مهار کننده تیروزین کیناز; biopsy; bronchoscopy; genetics; lung cancerEBUS-TBNA, endobronchial ultrasound-guided transbronchial needle aspiration; EGFR, epidermal growth factor receptor; LH, loop-hybrid; PCR, polymerase chain reaction; TKI, tyrosine kinase inhibitor
Gefitinib-induced pneumonitis in non-small cell lung cancer: radiological and clinical findings in five patients
Keywords: TKI، مهار کننده تیروزین کیناز; GGO, ground glass opacity; PCR, polymerase chain reaction; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; TGF, transforming growth factor; SP, surfactant protein; HRCT, high-resolution CTLung, pneumonitis, CT, simple radiograph; G
High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand
Keywords: TKI، مهار کننده تیروزین کیناز; EGFR; Adenocarcinoma; Lung cancer; Mutation; Tyrosine kinase inhibitor; GefitinibEGFR, epidermal growth factor receptor; NSCLC, non small cell lung cancer; TKI, tyrosine kinase inhibitor; bp, base pair
Dermatologic side effects associated with the epidermal growth factor receptor inhibitors
Keywords: TKI، مهار کننده تیروزین کیناز; CTCAE, Common Terminology Criteria for Adverse Events [National Cancer Institute]; EGFR, epidermal growth factor receptor; mAB, monoclonal antibody; TKI, tyrosine kinase inhibitor