کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115764 | 1084609 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand High frequency of mutation of epidermal growth factor receptor in lung adenocarcinoma in Thailand](/preview/png/2115764.png)
چکیده انگلیسی
Recent reports have suggested influences of racial difference on the frequency of mutation of EGFR in lung cancer. We therefore sought to characterize the frequency and pattern of mutation of EGFR in lung adenocarcinoma in Thai patients. Overall, EGFR catalytic domain mutations were detected in 35/61 (57.4%). We found 29/60 (48.3%) of exon 19 deletions, 5/54 (9.3%) of exon 21 point mutations, and 1/54 (1.9%) of double-mutation of both exons. The presence of these mutations was significantly associated with non-smoking habit. In summary, we report a strikingly high prevalence of mutation of EGFR in Thai lung adenocarcinoma, which may explain the high response rate to the treatment with TKI among Asian populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 239, Issue 2, 8 August 2006, Pages 292–297
Journal: Cancer Letters - Volume 239, Issue 2, 8 August 2006, Pages 292–297
نویسندگان
V. Sriuranpong, C. Chantranuwat, N. Huapai, T. Chalermchai, K. Leungtaweeboon, P. Lertsanguansinchai, N. Voravud, A. Mutirangura,